792 papers
This study demonstrates that extracellular vesicles secreted by a polymicrobial community of CF lung pathogens exacerbate innate immune responses and inhibit CFTR function in cystic fibrosis epithelial cells, explaining why highly effective modulator therapies like Trikafta fail to eliminate chronic infections or restore normal lung physiology.
The paper introduces PALM, a fast and reliable quasi-Poisson regression framework designed to improve false discovery control, statistical power, and computational efficiency in large-scale microbiome association studies and meta-analyses.
This study confirms that *Pleurotus ostreatus* cultivated on Nigerian agro-waste substrates (Gmelina sawdust, oil palm fiber, and cassava peels) yields bioactive extracts with significant antifungal and antioxidant properties, demonstrating that substrate choice substantially influences the mushroom's therapeutic potential.
This study reveals that in cyanobacteria, polyphosphate acts as a conserved architectural regulator that spatially organizes the nucleoid and carboxysomes to couple chromosome structure with metabolic compartmentalization and photosynthetic fitness.
This study introduces Termini, a modification-aware generative AI framework that designs potent antimicrobial peptides with optimized N- and C-terminal modifications, achieving a 92.5% in vitro activity rate and demonstrating robust therapeutic efficacy against a broad spectrum of pathogenic bacteria.
This study demonstrates that silver nanoparticles biosynthesized using *Azadirachta indica* leaf extract effectively inhibit multidrug-resistant and ESBL-producing *E. coli* strains while exhibiting low cytotoxicity to human kidney cells, suggesting their potential as a therapeutic agent for drug-resistant infections.
This study demonstrates that the gut microbiota, particularly specific bacterial genera like *Lachnospiraceae UCG.001* and *Lachnoclostridium*, partially mediates the protective association between high-quality MIND diet adherence and reduced ectopic adiposity (visceral and liver fat) in a multi-ethnic cohort of older adults.
This study demonstrates that the IL-1 family is essential for initiating mucosal immunity against *Candida albicans* by regulating antimicrobial peptides and neutrophil responses, thereby preventing local infection from progressing to fatal systemic dissemination, particularly in neutropenic patients.
The paper introduces LGTM, a probabilistic framework that integrates Gaussian processes with neural topic modeling to simultaneously discover interpretable microbial subcommunities and model their complex longitudinal dynamics in response to host and environmental covariates.
A multi-year experiment in a Mediterranean grassland reveals that reduced precipitation limits the movement of root-derived carbon into the surrounding soil while simultaneously intensifying microbial consumption and ecological interactions within the rhizosphere, offering a new mechanism for understanding how climate-driven drying affects soil carbon cycling.
This study identifies a conserved M16 peptidase in the gut commensal *Bacteroides* that regulates glucose homeostasis by cleaving metabolic targets like insulin and modulating glycolytic enzymes to control the transcriptional regulator Cur, thereby linking host glucose abundance to bacterial fitness and colonization.
This study presents a structure-guided computational pipeline that successfully designs peptide inhibitors targeting three key Cryptococcus neoformans peptidases to disarm fungal virulence and resistance mechanisms, thereby enhancing immune clearance and antifungal efficacy without harming mammalian cells or promoting resistance evolution.
This study presents a continental-scale multi-omics survey of Chinese sandy beaches, revealing a distinct, highly novel microbial-viral biome structured by tidal zonation that drives systematic metabolic shifts and encodes diverse biogeochemical transformation potentials.
This study demonstrates that specialized legume-based culture media derived from soybean and pea tissues effectively overcome the challenge of unstable sporulation in soybean-associated *Cercospora* species, offering a more reliable and robust alternative to standard artificial media for laboratory research.
This study introduces a scalable pooled screening approach to identify and characterize a novel group of *Pseudomonas* chemoreceptors that specifically sense short-chain C3 carboxylic acids, revealing how structural adaptations in their binding pockets enable ligand recognition despite sequence divergence from formate receptors.
This study establishes a unified taxonomic framework for the *Gardnerella* genus by analyzing 312 curated genomes to define 21 distinct lineages, while simultaneously uncovering novel plasmids, phages, and lineage-specific metabolic and virulence factors to advance the understanding and treatment of bacterial vaginosis.
Combining *Azospirillum brasilense* Sp7 with tomato exudate or cytidine significantly enhances tomato resistance to *Pseudomonas syringae* by modulating microbial community composition in the phyllosphere and rhizosphere, rather than directly reducing pathogen load in leaf tissues.
This pilot study demonstrates that following a complete rumen content exchange between low- and high-methane-yielding dairy cows, the host's intrinsic factors drive an asymmetric microbiome reconstitution where low emitters revert to their native microbial community while high emitters retain donor-like microbiota, ultimately preserving their original methane emission phenotypes.
This study demonstrates that fortifying yogurt with *Lactobacillus plantarum* and *Stevia rebaudiana* extract creates a synbiotic product with enhanced antioxidant activity, improved nutritional profile, and superior sensory attributes compared to control samples.
This study integrates sequence similarity networks and genomic analyses to map the functional diversification of the QueC protein family, revealing how its ancient scaffold has been evolutionarily repurposed from canonical tRNA modification and cofactor biosynthesis to novel anti-phage defense mechanisms.