15 papers
Integrating a clinical pharmacologist into an antimicrobial stewardship program for oncourology patients significantly improved adherence to antibiotic prophylaxis guidelines, reduced antibiotic consumption and costs by over 70%, and decreased the prevalence of resistant organisms without increasing infectious complications or mortality.
This single-center randomized controlled study demonstrates that applying topical anesthetics, such as Tetracaine Hydrochloride or Oxybuprocaine Gel, significantly reduces catheter-related bladder discomfort and urethral pain in patients undergoing ureteroscopic litholapaxy, with the analgesic benefit being particularly pronounced in male patients.
This systematic review and meta-analysis characterizes "UroLume Cripple Syndrome" as a chronic iatrogenic condition resulting from the UroLume endoprosthesis, synthesizing evidence on its high rates of complications and reconstructive challenges while estimating a small, institutionally invisible global survivor population in 2026 that urgently requires dedicated registries and specialized care pathways.
This study demonstrates that early-onset bladder cancer (diagnosed before age 55) represents a distinct molecular subtype characterized by a higher prevalence of specific somatic mutations, such as *KMT2D* and *FGFR3*, which differ from older patients and offer promising targets for personalized therapeutic strategies.
This study presents the development and external validation of an automated multimodal AI model that integrates biparametric MRI radiomics with clinical data to accurately predict biochemical recurrence after radical prostatectomy, demonstrating superior performance in stratifying intermediate-risk patients compared to standard clinical models.
This study demonstrates that quantitative high-frequency ultrasound can noninvasively identify regional testicular tissue heterogeneity associated with localized spermatogenesis in men with non-obstructive azoospermia, achieving high accuracy in distinguishing sperm-positive from sperm-negative sites and potentially guiding future image-guided sperm retrieval strategies.
This study demonstrates that genetic testing for monogenic kidney stone disease yields a significantly higher diagnostic rate in specialist clinical settings compared to unselected populations, while standard serum biochemistry fails to reliably identify at-risk individuals.
This study demonstrates that an intraoperative methylene blue test is a simple, high positive-predictive-value tool for guiding real-time patient selection for totally tubeless percutaneous nephrolithotomy in both mini and standard procedures.
In a cohort study of over 100,000 U.S. Veterans, older age at first PSA test and longer screening intervals were significantly associated with a higher risk of metastatic prostate cancer, highlighting the potential for optimizing screening strategies to reduce late-stage diagnoses.
This study characterizes the significant temporal variability and overlapping microbial profiles of the urobiome in asymptomatic individuals with spinal cord injury or disease, challenging current cross-sectional diagnostic assumptions and providing a foundation for developing precision-based thresholds to distinguish normal variation from true urinary tract infections.
This study demonstrates that an Expectation-Maximization framework effectively estimates clinically plausible chronic kidney disease stage transition probabilities from irregular electronic health record data in patients with small renal masses, offering a robust alternative to naive estimators for use in decision-analytic and health economic models.
In patients with Grade Group 2–4 prostate cancer, the total length of Gleason pattern 4 on biopsy is a superior predictor of adverse pathologic stage and biochemical recurrence compared to Grade Group, percent pattern 4, and standard clinical models.
This study demonstrates that pudendal nerve stimulation in awake humans effectively recruits the urethra and alters lower urinary tract pressures without significantly impacting voiding efficiency, suggesting a mechanism of action similar to sacral neuromodulation.
This study demonstrates that a panel of three circulating extracellular vesicle miRNAs (miR-92a-1-5p, miR-375, and miR-148a-3p), quantified via digital PCR, serves as a promising auxiliary diagnostic biomarker for distinguishing prostate cancer from benign prostatic hyperplasia and may aid in identifying bone metastasis.
This study demonstrates that quantitative ultrasound (QUS) biomarkers, particularly the spatial heterogeneity of the Nakagami k-factor in superficial testicular parenchyma, correlate significantly with sperm production and show promise as a non-invasive tool for predicting spermatogenesis in men with non-obstructive azoospermia.