199 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study introduces a seed-guided diffusion approach that overcomes the structural limitations of current de novo protein design methods by using geometrically complementary fragments to generate diverse, high-affinity antitoxin binders with enhanced selectivity against the bacterial toxin RelE.
This paper presents a language-model-guided framework that successfully improves the recombinant expression of clinical-stage antibody therapeutics by performing directed evolution within synonymous codon space, thereby enhancing manufacturing yields without altering protein sequences or compromising product quality.
This study demonstrates that bio-mimicked PDMS substrates fabricated from various leaf templates, particularly those from *Musaceae Banana* and *Dracaena Sanderiana*, effectively guide C2C12 cell alignment and morphology through specific groove patterns and hydrophobicity, offering a cost-effective alternative to traditional fabrication methods for tissue engineering.
This paper introduces a novel virtual staining framework that decouples structural guidance from image translation using domain-knowledge prompts and self-supervised learning, enabling high-fidelity, flexible synthesis of multiple subcellular structures from single-channel data without relying on rigidly paired multiplex fluorescence targets.
BioPathfinder is an evidence-guided multi-agent platform that integrates fragmented clinical and single-cell data to generate and validate novel hypotheses, successfully identifying NKG2A blockade as a strategy to enhance CAR-T cell persistence and antitumor activity.
This paper introduces a modular bio-hybrid skin model that integrates an optically tunable artificial epidermal layer with living human keratinocytes to create a reproducible, biologically responsive test system for biomedical optics that bridges the gap between inert synthetic models and variable tissue-engineered constructs.
The paper introduces Bio-CM{superscript 2}, a compact computational miniature mesoscope that utilizes distributed computational optics to overcome traditional trade-offs between field of view and spatial resolution, enabling simultaneous cortex-wide, cellular-resolution in vivo imaging across diverse biological systems.
This study presents a bioengineering strategy using surfactant-like peptides to stabilize pH-responsive, sub-micron membraneless organelles within synthetic cells, enabling precise size control that enhances enzymatic reaction rates and facilitates programmable functional compartmentalization.
This study presents a computationally guided metastasis-on-a-chip platform that utilizes finite-element simulations to rationally design microfluidic assays for quantitatively evaluating tumor-specific chemotactic responses to VEGF signaling, thereby minimizing empirical trial-and-error in studying developmental cancer metastasis.
This paper introduces the TMSE-BioCRNpyler Library and its accompanying txt2biocrnpyler tool to enable automated, interoperable mechanistic modeling of toehold-mediated strand exchange circuits across diverse biological contexts, validated by high accuracy against existing literature models.