139 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper presents a robust, rapid, and scalable strategy for the direct synthesis of targeted nanosized ICG J-aggregates via co-assembly and bio-orthogonal click chemistry, which overcome traditional limitations to serve as high-performance contrast agents for photoacoustic imaging.
This study demonstrates that increased functional medial collagen enhances aortic resilience against mural delamination caused by hydraulic fracturing, suggesting that elevated collagen levels represent an adaptive protective mechanism rather than a sign of medial degeneration.
This study establishes a photoacoustic tomography and ultrasound imaging system capable of resolving visually evoked hemodynamic responses in freely behaving mice, demonstrating its utility in detecting retinal degeneration by revealing that hemodynamic response amplitudes increase with both visual stimulation intensity and light adaptation time.
This study establishes a high-throughput peptide screening platform to identify specific RGD-containing sequences that effectively functionalize alginate scaffolds, thereby overcoming cell adhesion limitations and enabling the optimized engineering of sustainable cultivated meat tissues.
This paper presents a multi-scale computational model of the human myometrium that elucidates how tissue-level excitability and synchronized contractions emerge from cellular heterogeneity and inflammation-induced remodeling, providing a robust platform for studying gestational pathologies like preterm labor.
This paper presents a conductive hydrogel coating for radiofrequency ablation catheters that enhances tissue contact and lesion homogeneity while preventing steam pops, though further optimization of conductivity is required to match the lesion dimensions of bare metal catheters.
By employing a machine-learning-guided strategy to engineer a disulfide bond that restricts the mobility of a conserved lid loop in *Anabaena variabilis* phenylalanine ammonia-lyase, researchers demonstrated that this loop acts as a critical regulator of substrate specificity by modulating active-site conformational dynamics.
This paper introduces "directoids," a microfluidic platform utilizing micropatterned PDMS channels to achieve spatially controlled, directional axonal guidance and asymmetric functional connectivity between cortical and thalamic neural organoids, thereby enabling the study of hierarchical circuit formation with unprecedented cellular resolution.
This study demonstrates that in APP/PS1 mouse models of Alzheimer's disease, circadian disruption exacerbates sex-specific bone loss and fragility by inducing oxidative stress and dysregulating circadian timing in bone marrow monocytes and macrophages.
This study demonstrates that muscle coordination patterns for efficient locomotion must change across different body sizes due to the non-linear effects of muscle tissue inertia, which significantly alters metabolic costs and mechanical output as muscle mass scales.