139 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
The study demonstrates that the BiArticular Thigh EXosuit (BATEX), which mimics biological biarticular muscles and elastic tissues to enable both temporal energy storage and spatial energy transfer across joints, significantly reduces metabolic cost by up to 9% during walking by simultaneously assisting and augmenting human lower-limb function.
This study demonstrates that glycoengineered small extracellular vesicles derived from Caco-2 and HEK293T cells, functionalized with Gb3 trisaccharides via FSL conjugates, effectively serve as decoy receptors to neutralize Shiga toxin 1 subunit B without compromising cell viability, offering a promising therapeutic strategy against STEC infections.
The MMH dataset is a multimodal collection of whole-body kinematics, ground reaction forces, and lower-limb electromyography signals recorded during various lifting and lowering techniques, designed to support research in biomechanics, ergonomics, and musculoskeletal modeling.
This study demonstrates that Nanofitin-based affinity chromatography using the NF06 binder enables the scalable, selective enrichment of CD81-positive extracellular vesicles with high recovery, effective impurity clearance, and EV-compatible elution conditions.
This study establishes a direct link between the microstructural changes of neuronal loss and gliosis and the increased tissue stiffness in hippocampal sclerosis, demonstrating that nonlinear mechanical properties serve as promising diagnostic biomarkers for drug-resistant temporal lobe epilepsy.
This paper presents a gradient-specified optimization framework that automates musculotendon path modeling by simultaneously satisfying geometric constraints and matching experimental moment arm data, resulting in anatomically realistic and biomechanically accurate paths generated efficiently for large-scale applications.
This paper presents a hierarchical mechanically adaptive enzymatic biosensor (E-cardiac) that enables real-time, stable monitoring of cardiac oxidative stress on beating hearts by mitigating deformation-induced artifacts, thereby allowing for the precise differentiation of ischemia-reperfusion injury severity and guiding surgical interventions.
This study presents a membrane-free human alveoli-on-a-chip utilizing a biodegradable PLGA scaffold that is replaced by fibroblast-derived ECM to recapitulate native interstitial mechanics, thereby preventing stiffness-induced fibrosis, enabling immune cell trafficking, and facilitating efficient aerosolized mRNA delivery.
This study demonstrates that coordinating the engineering of a novel ionizable lipid (N4Z) with specific formulation adjustments redirects mRNA vaccine biodistribution from the liver to lymphoid tissues, thereby enhancing innate immune priming and driving robust, protective CD4+ T cell immunity.
This paper introduces a substrate-confined oligonucleotide linking strategy that coordinates the delivery of multiple AAV vectors, significantly improving the efficiency and uniformity of large genetic system reconstitution and prime editing at reduced viral doses.