279 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This study demonstrates that human pluripotent stem cell-derived neutrophils engineered with chimeric antigen receptors targeting fibroblast activation protein can selectively eliminate activated fibroblasts and improve cardiac function in a murine myocardial infarction model, offering a promising immunotherapeutic strategy for treating cardiac fibrosis.
This paper presents a surfactant-enhanced hybridization capture method using SDS that enables direct, near-quantitative extraction of low-abundance RNA from crude plasma and whole blood without prior separation, achieving ultrasensitive HIV detection and robust performance across viral subtypes through a novel probe design algorithm.
FLEX-DBS is a lightweight, wireless, head-mounted platform for rodents that enables programmable, bilateral constant-current deep brain stimulation with real-time control and autonomous operation, offering a flexible alternative to tethered systems despite a limited battery runtime of approximately three days.
This study demonstrates that while thick-walled, crosslinked densified collagen grafts face late thrombosis challenges in rat abdominal aorta models, a newly developed thin-walled, non-crosslinked variant with improved compliance and hemocompatibility successfully maintains patency for up to 17 weeks, establishing a scalable foundation for future large-animal evaluation.
This study demonstrates that longitudinal local centile maps, which contextualize cartilage thickness against normative growth charts, significantly outperform conventional imaging features and raw deep learning maps in predicting incident radiographic knee osteoarthritis at 12 and 24 months.
This study presents 3D biomimetic scaffolds nanoprinted onto photovoltaic arrays to accurately replicate the subretinal debris gap found in geographic atrophy, thereby enabling more precise preclinical evaluation of subretinal prostheses by controlling the distance between the implant and target neurons.
This study demonstrates that pulsed field ablation (PFA) effectively reduces pancreatic ductal adenocarcinoma growth by inducing tumor cell death and reprogramming the stromal microenvironment from tumor-promoting myofibroblasts to complement-secreting fibroblasts, thereby suppressing epithelial-to-mesenchymal transition and enhancing therapeutic control.
This paper introduces "cell chirp," a highly sensitive ultrasound imaging technique that utilizes genetically encoded gas vesicles to enable the real-time, longitudinal tracking of single, genetically defined cells within optically opaque tissues by exploiting their unique harmonic response to frequency-coded sound waves.
This study presents a structure-guided workflow that combines high-stringency SELEX, biophysical characterization, and molecular modeling to discover and optimize two distinct methotrexate-binding DNA aptamer families, which were successfully integrated into electrochemical sensors capable of sensitive, selective, and reagent-less therapeutic drug monitoring in undiluted human blood.
The paper introduces FD-SCoPE, a feedback-driven language model framework that enhances clinicians' ability to query and derive insights from systematic review evidence tables by combining executable queries with expert corrections to provide auditable, high-accuracy answers.