📄 Category

bioengineering

196 papers

Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.

At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.

📄 bioengineering

Validation of a multiscale Hill-type actuator against comprehensive benchmarks of motor unit and muscle force measurements

This study presents and systematically validates a novel multiscale, fibre-type-specific Hill-type neuromuscular actuator with refined mechanistic excitation-activation dynamics against comprehensive experimental benchmarks spanning motor unit and whole-muscle scales, demonstrating its ability to accurately reproduce muscle forces across diverse physiological conditions.

Sgarzi, A., Caillet, A. H., Millard, M., Weidner, S., Haralabidis, N., Meranger, T., Bolsterlee, B., Farina, D., Lovell (…)2026-06-18
📄 bioengineering

Selectivity of Lateral Epidural Spinal Cord Stimulation with Varying Electrode Diameters and Stimulation Configurations

This study combines feline electrophysiology and computational modeling to demonstrate that while reducing electrode contact diameter can improve the focal selectivity of lateral spinal cord stimulation, gains plateau below 1000 µm and further reductions may not enhance selectivity due to inherent physiological constraints.

Ansah, G. J., Del Brocco, M., Bhowmick, S., Duran, M. A., Gopinath, C. H., Jantz, M. K., Lempka, S. F., Fisher, L.2026-06-17
📄 bioengineering

Filling the Void: Rapid Revascularization via Vasculogenic Assembly in Semi-synthetic Granular Hydrogel Grafts

This study demonstrates that granular hydrogel composites (GHCs) filled with fibrin and collagen enable rapid, pre-culture-free revascularization of embedded endothelial cells and successfully restore blood flow to human ovarian tissue grafts within 10 days of implantation, offering a promising platform for enhancing the survival of engineered tissue transplants.

Hu, M. M., Pavlidis, D. I., Lestock, C., Anyosa-Galvez, G., Lollis, K., Zhao, Y., Midekssa, F. S., Kent, R. N., Shikanov (…)2026-06-16
📄 bioengineering

Bi-level inverse optimal control for preoperative prediction of postoperative squat kinematics after total knee replacement

This study developed a bi-level inverse optimal control framework that successfully reproduces postoperative squat kinematics in total knee replacement patients using either subject-specific or group-level cost functions, offering a promising foundation for future preoperative prediction of how implant alignment affects dynamic functional outcomes.

Song, H.2026-06-15
📄 bioengineering

A combinatorial DNA origami platform for biologically replicable, thermostable data storage and molecular authentication

This paper introduces DOCS, a combinatorial DNA origami platform that encodes information into scaffold molecules to achieve biologically replicable, thermostable, and randomly accessible data storage and molecular authentication, bridging the gap between classical sequence-based storage and DNA nanostructure methods.

Fördos, F., Kloosterman, A. M., Lindberg, A., Shen, B., Baars, I., Högberg, B.2026-06-11
📄 bioengineering

Multiplex engineering of rhesus macaque NK cells enhances homing to sites of HIV replication in B cell follicles.

This study demonstrates that multiplex-engineered rhesus macaque NK cells, modified to express CAR, CXCR5, IL-15, PD-1 knockout, and transient CCR7, are safe, expandable, and effectively home to SIV viral reservoirs within B cell follicles of lymphatic tissues, offering a promising strategy for HIV cure development.

Thron, L. K., Pampusch, M. S., Chang, J. W., Krueger, J., Cantor, M. E., Johnson, M. J., Dudley, D. M., Moriarity, B., S (…)2026-06-11
📄 bioengineering

Cell-Dense Bioink Design for Xolography: Coupling Refractive Index-Matching with Increased Photoreactivity

This study advances Xolography for tissue engineering by developing a refractive index-matched bioink using iodixanol that enables high-resolution, volumetric printing of cell-dense (up to 5×10⁶ cells/mL) constructs with complex geometries and functional skeletal muscle tissue formation, while navigating the critical trade-off between optical transparency and photochemical reactivity.

Balciunaite, A., Inacker, S., Badolato, A., Brauer, E., Konig, N. F., Lima, L. V., Humphreys, G. R., Polinari, C., Palat (…)2026-06-08