234 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper proposes and validates a mechanical theory demonstrating that local stress fields generated by cortical folding guide the reorientation of growing axons, thereby explaining the preferential formation of U-shaped short association fibers between gyri.
The authors present the "Cell Trainer," an open-source automated platform that utilizes timed drug pulses and real-time feedback control to study adaptive learning and memory-like behaviors in non-neural mammalian cells, thereby bridging gaps in understanding cellular physiological plasticity.
This paper introduces a cuffed CRISPR guide RNA (cgRNA) system that enables miRNA activity-dependent genome editing, allowing for cell state-specific gene modulation, miRNA activity mapping, and the irreversible recording of molecular cell states.
This study evaluated the feasibility of using the crossmodal congruency task to measure the intuitiveness of sensory feedback in the lower limb, finding that while it successfully differentiated between pneumatic and electric sensations at the knee, it failed to do so at the foot, indicating a need to identify external factors before applying the method to amputees.
This study demonstrates that green hydrogen can serve as a stoichiometric electron donor in a cell-free enzymatic system to drive the complete, byproduct-free bioconversion of pyruvate to lactate via efficient NADPH regeneration, offering a scalable platform for reductive biotransformations powered by renewable energy.
This study introduces a seed-guided diffusion approach that overcomes the structural limitations of current de novo protein design methods by using geometrically complementary fragments to generate diverse, high-affinity antitoxin binders with enhanced selectivity against the bacterial toxin RelE.
This paper presents a language-model-guided framework that successfully improves the recombinant expression of clinical-stage antibody therapeutics by performing directed evolution within synonymous codon space, thereby enhancing manufacturing yields without altering protein sequences or compromising product quality.
This study demonstrates that bio-mimicked PDMS substrates fabricated from various leaf templates, particularly those from *Musaceae Banana* and *Dracaena Sanderiana*, effectively guide C2C12 cell alignment and morphology through specific groove patterns and hydrophobicity, offering a cost-effective alternative to traditional fabrication methods for tissue engineering.
This paper introduces a novel virtual staining framework that decouples structural guidance from image translation using domain-knowledge prompts and self-supervised learning, enabling high-fidelity, flexible synthesis of multiple subcellular structures from single-channel data without relying on rigidly paired multiplex fluorescence targets.
BioPathfinder is an evidence-guided multi-agent platform that integrates fragmented clinical and single-cell data to generate and validate novel hypotheses, successfully identifying NKG2A blockade as a strategy to enhance CAR-T cell persistence and antitumor activity.