280 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper presents a computational pipeline, available as both an interactive 3D Slicer extension and a command-line tool, that stabilizes adaptive optics line confocal ophthalmoscopy videos against eye motion and accurately quantifies retinal capillary blood flow velocities with a 4% error margin.
This paper introduces T-REX, an agentic framework that orchestrates multiple protein generative models and evaluators using LLMs to dynamically decide between rescuing, exploring, or exploiting design strategies, thereby optimizing high-throughput de novo binder creation within finite compute budgets.
This study demonstrates the successful use of a compact CZT-based Compton camera to achieve quantitative in vivo tomography and biodistribution analysis of 225Ac daughters in a prostate cancer mouse model, overcoming the limitations of conventional SPECT to accurately visualize and quantify tumor uptake at low activity levels.
This study demonstrates that megascale recombination of ten bacterial PETase sequences can generate millions of diverse, catalytically competent chimeric enzymes, proving that large-scale sequence recombination is a scalable and effective strategy for protein engineering compatible with modern high-throughput screening.
This study presents a physiologically detailed biomechanical model of the mouse distal forelimb that successfully simulates complex, coordinated grasping movements and generates muscle excitation patterns consistent with experimental data, thereby establishing a robust framework for investigating fine motor control and neurological disorders.
This study establishes a scalable biomanufacturing pipeline that utilizes emulsion-generated high-concentration alginate beads to encapsulate pluripotent stem cell-derived islets, effectively preventing agglomeration and mechanical stress during extended bioreactor culture while maintaining their differentiation potential and in vivo functionality for type 1 diabetes transplantation.
BoneGraph is a locally deployed, domain-specialized system for bone science that unifies curated retrieval, self-correcting reasoning with physics and knowledge-graph constraints, and multimodal vision-mechanics capabilities to overcome the limitations of general-purpose large language models in synthesizing reliable, evidence-based scientific knowledge.
This paper introduces FlyMOE, a chemical-genetic platform that enables targeted, in vivo profiling of the Drosophila melanogaster glycoproteome by engineering transgenic flies to incorporate bioorthogonally-tagged monosaccharides for mass spectrometry analysis.
This study demonstrates that incorporating cell-specific heteroclinic orbits and mechanical heterogeneity, rather than relying solely on size-based separation, is crucial for optimizing inertial microfluidic devices to minimize white blood cell carryover during circulating tumour cell isolation.
This study introduces a microfluidic culture system that generates spatial gradients of growth factors within fibrin hydrogels to enable real-time, high-throughput screening of optimal conditions for expanding CD34+ hematopoietic stem cells, offering a more efficient alternative to traditional suspension culture methods.