📄 Category

bioengineering

196 papers

Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.

At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.

📄 bioengineering

Systematic Evaluation of Signal Peptide-Driven Protein Secretion in the Fast-Growing Cyanobacterium Synechococcus sp. PCC 11901

This study establishes *Synechococcus* sp. PCC 11901 as a secretion-competent chassis for photosynthetic biomanufacturing by systematically evaluating signal peptides, revealing that while the Tat pathway leader FutA outperforms Sec candidates for eYFP, optimal signal peptide selection is cargo-dependent, as evidenced by the superior performance of the thermitase Sec signal for lichenase secretion.

Moreno-Cabezuelo, J. A., Booth, A., Lin, D., Gathani, K., Kim, D., Sagaram, U. S.2026-05-22
📄 bioengineering

Retinal Electrophysiological Patterns in Alzheimer's Disease: A Multi-Domain Signal Processing Framework for Non-Invasive Biomarker Discovery Using a Portable ERG Device

This pilot study demonstrates that a multi-domain signal processing framework applied to portable electroretinogram (ERG) recordings can effectively identify novel retinal temporal dysfunction biomarkers, achieving 85.8% accuracy in distinguishing Alzheimer's disease patients from controls and supporting the potential of portable ERG devices for early, non-invasive AD detection.

Barria, J. A., Slachevsky, A., Palacios, A. G., Medina, L. E.2026-05-22
📄 bioengineering

A Comprehensive Computational Model of the Human head for Designing and Optimizing Visual Brain-Machine Interfaces

This paper presents and validates a comprehensive computational model of the human head that integrates the entire visual pathway and surrounding tissues to optimize visual brain-machine interfaces, demonstrating its utility in evaluating neuromodulation technologies, identifying superior stimulation sites, and designing advanced electrode arrays for vision restoration.

Lu, S., Yang, T., Geng, Y., Wu, H., Huang, Y., Zheng, T., Chen, H., Huang, S., Cao, Y., Yang, J., Yan, W., Zhang, Y., Wu (…)2026-05-18
📄 bioengineering

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

This study demonstrates that using bispecific cytokine receptor-targeting chimeras (KineTACs) to induce targeted extracellular degradation of the selenium uptake receptor LRP8 effectively depletes the ferroptosis-protective enzyme GPX4, thereby sensitizing cancer cells to ferroptosis and offering a novel strategy to overcome therapy resistance.

Zhao, F., Inague, A., Peters-Clarke, T. M., Chen, Y., Ganjave, S. D., Zhang, Y., Miao, K., Yao, Z., Wu, Y., Seto, M. K. (…)2026-05-18
📄 bioengineering

Direct Synthesis of Targeted Nanosized ICG J-aggregate for Photoacoustic Imaging

This paper presents a robust, rapid, and scalable strategy for the direct synthesis of targeted nanosized ICG J-aggregates via co-assembly and bio-orthogonal click chemistry, which overcome traditional limitations to serve as high-performance contrast agents for photoacoustic imaging.

Singh, S., Soto Cordova, L., Such, N., Hanafi, M., Giammanco, G., Lawrence, D. J., Hill, I. E., Chamanara, B., Fenaoui (…)2026-05-15
📄 bioengineering

Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing

This study demonstrates that increased functional medial collagen enhances aortic resilience against mural delamination caused by hydraulic fracturing, suggesting that elevated collagen levels represent an adaptive protective mechanism rather than a sign of medial degeneration.

Chou, A., Wang, K., Lieu, D., Vallabhajosyula, P., Humphrey, J. D., Tellides, G., Assi, R.2026-05-15
📄 bioengineering

Peptide screening enables optimised biofunctional hydrogels for cultivated meat tissue engineering

This study establishes a high-throughput peptide screening platform to identify specific RGD-containing sequences that effectively functionalize alginate scaffolds, thereby overcoming cell adhesion limitations and enabling the optimized engineering of sustainable cultivated meat tissues.

Melzener, L., Spaans, S., Borlin, C. S., Hauck, N., Post, M. J., Dogan, A., Flack, J. E.2026-05-13
📄 bioengineering

A Computational Functional Tissue Unit of the Human Myometrium for In Silico Study of Gestational Excitability and Pathophysiology

This paper presents a multi-scale computational model of the human myometrium that elucidates how tissue-level excitability and synchronized contractions emerge from cellular heterogeneity and inflammation-induced remodeling, providing a robust platform for studying gestational pathologies like preterm labor.

Hussan, J. R., Means, S. A., Hunter, P. J., Clark, A. R.2026-05-09