gastroenterology papers

Gastroenterology explores the complex journey of digestion, examining how our bodies break down food, absorb nutrients, and manage waste. This vital field investigates everything from the stomach and intestines to the liver and pancreas, addressing common issues like heartburn and irritable bowel syndrome alongside more serious conditions affecting digestive health.

At Gist.Science, we bring the latest breakthroughs directly from medRxiv, the leading preprint server for health sciences. We process every new submission in this category as soon as it is posted, transforming dense research into both plain-language overviews and detailed technical summaries so you can understand the science without getting lost in jargon.

Below are the most recent papers in gastroenterology, offering fresh insights into digestive health and disease management.

🩺 gastroenterology

Histopathologic Spectrum of Focal Liver Lesions Diagnosed by Ultrasound-Guided Percutaneous Liver Biopsy and Predictors of Hepatocellular Carcinoma: A Single-Center Experience from Sub-Saharan Africa

This single-center study from sub-Saharan Africa demonstrates that ultrasound-guided percutaneous liver biopsy is a safe and effective diagnostic tool for focal liver lesions, revealing hepatocellular carcinoma as the predominant pathology and identifying chronic viral hepatitis and larger tumor size as significant predictors of the disease.

Elias, T. P., Shewaye, A. B., Berhane, K. A., Mohammed, A., Tibebu, Z., Gebreselassie, A. G., Abie, A. S.2026-08-18

🩺 gastroenterology

ChatIBD: design, safeguards, and early international use of a guideline-grounded generative AI tool for inflammatory bowel disease (IBD) professionals

This paper describes the design, operational safeguards, and early international deployment of ChatIBD, a retrieval-augmented generative AI tool for inflammatory bowel disease professionals that demonstrated feasibility and global uptake over its first six months while emphasizing the need for further formal validation of its accuracy and clinical effectiveness.

Chuah, C. S., Gros, B., Plevris, N.2026-07-30

🩺 gastroenterology

Helicobacter Pylori fecal antigen positivity in clinically suspected Peptic ulcer disease adults in Dar es Salaam.

In a 2025 cross-sectional study of 390 adults in Dar es Salaam clinically suspected of peptic ulcer disease, 41.3% tested positive for *Helicobacter pylori* via fecal antigen, with tap water consumption identified as the sole significant risk factor and a positive correlation found between the infection and clinical suspicion of the disease.

Lweno, N. H., Lwakubuna, W. C., Gwambegu, A. D., Mgonda, Y. M.2026-07-29

🩺 gastroenterology

GutCore: An Endoscopy Foundation Model for Whole-Case Gastric Cancer Analysis

The study introduces GutCore, a foundation model pretrained on 5.6 million endoscopic images that successfully aggregates whole-case data to achieve high-accuracy, patient-level assessment of gastric cancer detection, invasion depth, biomarker status, and prognosis without relying on selected representative frames.

Kim, S., Yoo, H., Yoo, S.-K., Lee, J., Min, Y. W., Lee, H.2026-07-19

🩺 gastroenterology

Artificially sweetened beverage intake and risk of liver-related adverse events in individuals with MASLD: A prospective UK Biobank cohort study

This prospective UK Biobank cohort study of over 50,000 individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) found that consuming more than one serving of artificially sweetened beverages per day is associated with a significantly increased risk of liver-related adverse events, though not liver-related death.

xu, n., Lin, J., Liu, L., Zhu, S., Li, R., Zhu, J., Xu, C.2026-07-08

🩺 gastroenterology

Somatic Mutation Profiles in Colorectal Cancers Differ by Population

This study utilized somatic mutation profiling of colorectal tumors from African Americans, Ghanaians, Ethiopians, and non-Hispanic Whites to reveal significant population-specific differences in tumor characteristics, including mutation rates in key genes like APC and TP53, as well as variations in age at diagnosis and tumor location.

Mabvakure, B. M., Promprasert, P., Martinez Cruz, L., Patil, S., Barros, J., Hayhurst, M., Mohebbi, E., de la Caridad De (…)2026-06-29

🩺 gastroenterology

Comparative Evaluation of Machine Learning and Deep Learning Models for Early Prediction of Severe Acute Pancreatitis: A Multi-Model Study Using the 2012 Revised Atlanta Classification

This study demonstrates that classical machine learning models, particularly Random Forest, outperform various deep learning architectures in the early prediction of severe acute pancreatitis using routine admission data from a cohort of 722 patients.

stern, N.2026-06-23

🩺 gastroenterology

Multidimensional nutritional assessment in Crohns disease: cross-sectional comparison of active disease and remission

This cross-sectional study of 127 Crohn's disease patients reveals that malnutrition is highly prevalent, particularly during active disease, and underscores the necessity of a multidimensional assessment approach combining anthropometric measures and clinical tools over relying solely on biochemical markers.

Sarker, A., Ghosh, C. K., Chowdhury, P.2026-06-15

🩺 gastroenterology

Exploring healthcare experiences and access needs in unplanned hospital admissions for Inflammatory Bowel Disease: A multi-perspective qualitative study

This qualitative study of 25 participants reveals that unplanned hospital admissions for Inflammatory Bowel Disease are driven by a complex interplay of difficulties in identifying flares, systemic barriers within a disjointed healthcare system, and emergency care gaps, necessitating proactive strategies like rapid-access pathways and enhanced patient education to improve access and reduce admissions.

Hawkins, R. L., Cotterill, C., McCormick, S., Kellar, I., Lobo, A. J., Sampson, F. C.2026-05-27

🩺 gastroenterology

A Randomized Controlled Trial Comparing Soy-Pea Protein to Animal Protein in Adults with Crohns Disease

In a randomized controlled trial involving adults with Crohn's disease, a 7-day diet replacing animal protein with soy-pea protein demonstrated significant anti-inflammatory benefits, particularly in reducing fecal myeloperoxidase and improving disease activity scores among participants with lower baseline disease activity.

Basson, A. R., Katz, J., Nguyen, V., Singh, D., Menghini, P., Gomez-Nguyen, A., Sieg, J., Bell, M., Thamma, K., Ponzani (…)2026-05-20