gastroenterology papers

Gastroenterology explores the complex journey of digestion, examining how our bodies break down food, absorb nutrients, and manage waste. This vital field investigates everything from the stomach and intestines to the liver and pancreas, addressing common issues like heartburn and irritable bowel syndrome alongside more serious conditions affecting digestive health.

At Gist.Science, we bring the latest breakthroughs directly from medRxiv, the leading preprint server for health sciences. We process every new submission in this category as soon as it is posted, transforming dense research into both plain-language overviews and detailed technical summaries so you can understand the science without getting lost in jargon.

Below are the most recent papers in gastroenterology, offering fresh insights into digestive health and disease management.

Exploring healthcare experiences and access needs in unplanned hospital admissions for Inflammatory Bowel Disease: A multi-perspective qualitative study

This qualitative study of 25 participants reveals that unplanned hospital admissions for Inflammatory Bowel Disease are driven by a complex interplay of difficulties in identifying flares, systemic barriers within a disjointed healthcare system, and emergency care gaps, necessitating proactive strategies like rapid-access pathways and enhanced patient education to improve access and reduce admissions.

Hawkins, R. L., Cotterill, C., McCormick, S., Kellar, I., Lobo, A. J., Sampson, F. C.2026-05-27🩺 gastroenterology

A Randomized Controlled Trial Comparing Soy-Pea Protein to Animal Protein in Adults with Crohns Disease

In a randomized controlled trial involving adults with Crohn's disease, a 7-day diet replacing animal protein with soy-pea protein demonstrated significant anti-inflammatory benefits, particularly in reducing fecal myeloperoxidase and improving disease activity scores among participants with lower baseline disease activity.

Basson, A. R., Katz, J., Nguyen, V., Singh, D., Menghini, P., Gomez-Nguyen, A., Sieg, J., Bell, M., Thamma, K., Ponzani, G., Osme, A., Rodriguez-Palacios, A., Cominelli, F.2026-05-20🩺 gastroenterology

Early prediction of skeletal muscle loss using longitudinal clinical data in patients with gastric cancer after radical gastrectomy and adjuvant chemotherapy: a retrospective cohort study

This retrospective cohort study demonstrates that an interpretable multilayer perceptron model utilizing routinely available longitudinal clinical data, particularly dynamic changes in nutritional and inflammatory status, can effectively predict significant skeletal muscle loss in gastric cancer patients following radical gastrectomy and adjuvant chemotherapy.

Wang, H., Ma, K., Lin, J., Zhu, J., Sun, M., Liang, S., Wang, H., Yang, B., Mu, L.2026-04-30🩺 gastroenterology

Explainable machine learning for revisiting reported Irritable Bowel Syndrome correlates in a student cohort

By reanalyzing a dataset of Bangladeshi students with Explainable Boosting Machines and addressing data quality issues, this study identifies psychological distress, elevated BMI, and academic dissatisfaction as key predictors of Irritable Bowel Syndrome while revealing non-linear patterns and weaker gender associations that diverge from previous logistic regression findings.

Ramirez-Lopez, L., Kang, P.2026-04-15🩺 gastroenterology

A Multi-Cohort Study of Immunoglobulin G Glycans in Newly Diagnosed Inflammatory Bowel Disease Patients Reveals Accelerated Biological Aging

This multi-cohort study demonstrates that IgG N-glycan profiles in newly diagnosed inflammatory bowel disease patients consistently reveal accelerated biological aging and can robustly distinguish patients from controls across diverse demographics using machine learning.

Flevaris, K., Trbojevic-Akmacic, I., Goh, D., Lalli, J. S., Vuckovic, F., Capin Vilaj, M., Stambuk, J., Kristic, J., Mijakovac, A., Ventham, N., Kalla, R., Latiano, A., Manetti, N., Li, D., McGovern (…)2026-04-11🩺 gastroenterology

Multimodal Wearable and Survey Data Reveal Distinct Physiologic Profiles in Hypermobile-Ehlers Danlos Syndrome for Screening Advancements

This study demonstrates that combining 30-day medical-grade wearable monitoring with symptom surveys reveals distinct autonomic and blood pressure instability profiles in individuals with hypermobile Ehlers-Danlos Syndrome compared to healthy controls, supporting a hybrid screening approach to significantly reduce diagnostic delays.

Wilson, D. A., Shilling, M., Nowak, T., Wo, J. M., Francomano, C. A., Everett, T., Ward, M. P.2026-04-03🩺 gastroenterology

Clinicopathological Factors Associated with Gastric Signet Ring Cell Carcinoma in CDH1 Pathogenic Variant Carriers: Report from the GASTRIC Consortium

This study from the GASTRIC consortium identifies that while the absence of endoscopic findings is reassuring for CDH1 carriers, the presence of specific abnormalities like masses or signet ring cell foci are independent predictors of advanced gastric cancer, suggesting endoscopic surveillance may be a viable alternative to prophylactic gastrectomy for those without worrisome mucosal findings.

Gilad, O., Drogan, C. M., Keel, E., Gao, G., Swallow, C., Govindarajan, A., Brar, S., Heller, M., Apostolico, T., Jacobs, M. F., Gofar, K., Dudley, B., Karloski, E., Lombardi, C., Springer, M., Saha (…)2026-04-02🩺 gastroenterology

Regular Use Of Antithrombotic Drug Increases The Risk Of Nonbiliary Acute Pancreatitis: A Prospective Cohort Study

This prospective cohort study of over 430,000 UK Biobank participants found that regular use of antithrombotic drugs, particularly clopidogrel, is associated with an increased risk of nonbiliary acute pancreatitis, with warfarin use specifically elevating risk in non-diabetic individuals.

Wei, C., Zhao, J., Mi, N., An, Z., Chen, S., Li, P., Lin, Y., Yue, P., Yuan, J., Meng, W.2026-03-16🩺 gastroenterology

Increased Risk of Portal Hypertension-Related Complications in Those with History of Bariatric Surgery and Alcohol-Associated Hepatitis

This study demonstrates that patients with a history of bariatric surgery who develop alcohol-associated hepatitis face a significantly increased long-term risk of portal hypertension-related complications compared to those without prior bariatric surgery, despite having similar rates of liver transplantation and all-cause mortality.

Havranek, B., Rohan, T. Z., Khakh, C. K., Redfield, R., Halegoua-DeMarzio, D.2026-03-14🩺 gastroenterology

Causal associations of body mass index and waist-to-hip ratio with acute appendicitis: a Mendelian randomization study

This Mendelian randomization study provides evidence for a potential causal relationship between obesity-related traits and acute appendicitis risk, specifically demonstrating that a higher waist-to-hip ratio independently increases susceptibility to the condition even after adjusting for body mass index.

Li, F., Qi, Q. Y., Wang, W. Y., Gong, G. S., Li, L. T., JinJin, J. M., Wang, W. C.2026-03-12🩺 gastroenterology