🦴 Category

rheumatology

25 papers

Assessment of long-term damage and cardiovascular risk in juvenile systemic lupus erythematosus compared to juvenile dermatomyositis in adulthood

This study compares adult outcomes of juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM), revealing that while damage accumulation is similar between the two groups, JSLE patients exhibit significantly higher traditional cardiovascular risk factors and PDAY scores, underscoring a distinct long-term cardiovascular burden in JSLE.

Li, J., Ali, I., Mailoo, T. + 4 more2026-04-04🦴 rheumatology

Course of Itch from Systemic Sclerosis Onset: a Scleroderma Patient-Centred Intervention Network Cohort Longitudinal Study

This longitudinal study of over 2,000 systemic sclerosis patients reveals that itch is a common and moderately severe symptom that remains stable in both prevalence and intensity regardless of disease onset age or duration, challenging the previous belief that itch is most significant only in early disease.

Goldberg, M., Carrier, M.-E., Yosipovitch, G. + 30 more2026-04-02🦴 rheumatology

cliexa-RA Implementation in Colorado Arthritis Center: A Case Study of Quadruple Aim Impacts

A six-month pilot study at the Colorado Arthritis Center demonstrates that the cliexa-RA digital platform significantly enhances rheumatoid arthritis management by reducing patient intake and clinician documentation times by 52% and 77% respectively, while simultaneously improving patient satisfaction, workflow efficiency, and administrative cost-effectiveness within the Quadruple Aim framework.

Kazgan, M.2026-04-01🦴 rheumatology

Reduced circulating anti-CXCR3 antibodies as a common hallmark bridging systemic autoimmunity and atherosclerosis

This study identifies reduced circulating anti-CXCR3 antibodies as a shared biomarker linking systemic autoimmune diseases like rheumatoid arthritis and Sjögren's disease with increased atherosclerosis risk, suggesting their potential to improve cardiovascular risk stratification and therapeutic monitoring.

Miranda-Prieto, D., Alperi-Lopez, M., Perez-Alvarez, A. I. + 6 more2026-03-30🦴 rheumatology

Type-1 interferon-driven innate and GZMK+ CD8 T cell activation precedes subclinical joint inflammation when rheumatoid arthritis is imminent

This study identifies that type-1 interferon-driven activation of specific immune cells precedes subclinical joint inflammation in individuals at imminent risk of rheumatoid arthritis, while a shift toward tissue-directed inflammatory and cytotoxic programs occurs concurrently with the onset of detectable synovitis.

Tariq, F., Martin, P., Abacar, K. + 12 more2026-03-30🦴 rheumatology

Autoimmunity and Arthritis in Youth with Autism and Suspected Post-Infectious Deteriorations

This study of 43 youth with autism spectrum disorder experiencing suspected post-infectious neuropsychiatric deterioration reveals a high prevalence of autoimmune conditions, particularly juvenile arthritis, and immune activation markers, suggesting that underlying inflammation may contribute to behavioral regression and warrants targeted immunologic and rheumatologic evaluation.

Ma, M., Schlenk, N., Sandberg, J. + 13 more2026-03-23🦴 rheumatology

The results of Transcriptome-wide Mendelian Randomization (TWMR) in large-scale populations can directly validate, across scales, the results of causal inference from deep learning combined with double machine learning on single-cell transcriptomes of human samples.

This study demonstrates that transcriptome-wide Mendelian randomization results from large-scale population data significantly correlate with causal inferences derived from deep learning and double machine learning on single-cell transcriptomes, thereby validating a cross-scale convergence of statistical and systems biology that bridges the translational gap in understanding complex diseases like rheumatoid arthritis.

ye, w., Jiang, X., Shen, F.2026-03-19🦴 rheumatology

Efficacy and Safety of Iguratimod Combined with Yunke Injection in the Treatment of Ankylosing Spondylitis

This retrospective cohort study demonstrates that combining Iguratimod with Yunke injection is a safe and effective alternative treatment for Ankylosing Spondylitis patients with contraindications to biologics or JAK inhibitors, offering superior disease activity improvement and reduced NSAID dependency compared to Iguratimod monotherapy without increasing adverse reactions.

shiyu, z., chen, l.2026-03-17🦴 rheumatology

A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals

This study of 59,475 UK Biobank participants reveals that radiographic hip and knee osteoarthritis exhibit distinct patterns of inter-joint relationships, symptom associations, and risk factor profiles, highlighting the heterogeneity of the disease and the need for joint-specific treatment approaches.

Hashmi, A., Scott, S., Jung, M. + 11 more2026-03-17🦴 rheumatology

Single-cell RNA-seq reveals a persistent interferon signature in immune cells from Systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment

Despite antimalarial treatment and low disease activity, single-cell RNA sequencing reveals that Systemic lupus erythematosus patients with high polygenic risk scores exhibit a persistent interferon signature across multiple immune cell types compared to those with low risk scores or healthy controls.

Sayadi, A., Eloranta, M.-L., Oparina, N. + 6 more2026-03-13🦴 rheumatology

Methylation Risk Score Identifies an Interferon-Driven SLE Subset Distinct from Polygenic Risk

This study demonstrates that a methylation risk score (MRS) identifies a distinct, interferon-driven subset of systemic lupus erythematosus (SLE) characterized by specific autoantibodies and HLA-DRB1*03:01, which is phenotypically and mechanistically separate from the nephritis-associated risk defined by polygenic genetic scores.

Vestin, H., Oparina, N., Eloranta, M.-L. + 9 more2026-03-11🦴 rheumatology

Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies

This study establishes autoantibody internalization as a shared pathogenic mechanism across diverse autoimmune diseases by demonstrating that patient-derived antibodies enter cells, induce specific transcriptomic signatures and inflammatory responses in multiple cell types, and drive tissue damage through a unified framework.

Pinal-Fernandez, I., Pak, K., Casal-Dominguez, M. + 36 more2026-03-05🦴 rheumatology

A Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk

This study identifies the W335S missense variant in the APOH gene as a causal factor that paradoxically increases anti-β2-glycoprotein I autoantibody levels while simultaneously reducing venous thromboembolism risk by disrupting phospholipid binding, thereby uncoupling autoimmunity from thrombosis and offering a potential biomarker for thrombotic risk stratification.

Lalaurie, C., Liu, L., Khan, A. + 7 more2026-03-05🦴 rheumatology

Expanding the clinical spectrum of autoimmune inflammatory myopathies with prominent B cell aggregates: a case series

This retrospective case series of 22 patients with autoimmune inflammatory myopathies featuring prominent B cell aggregates reveals a distinct clinical phenotype characterized by frequent comorbid systemic autoimmune diseases and specific muscle weakness patterns, alongside novel pathophysiological insights showing the presence of tertiary lymphoid structures in muscle biopsies.

ramanathan, b., Cheng Shen, H., Hudson, M. + 12 more2026-03-03🦴 rheumatology

Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis

This study reveals that mosaic chromosomal alterations, specifically autosomal copy-number loss (Loss) and mosaic loss of heterozygosity (mLOX), are significantly and differentially associated with systemic sclerosis and its clinical subtypes, particularly in patients with late-onset disease and high cell fractions, suggesting these genetic events contribute to the phenotypic heterogeneity of the condition.

Nishio, Y., Ishikawa, Y., Uchiyama, S. + 19 more2026-03-03🦴 rheumatology