5759 papers
This study integrates multi-omics bioinformatics analysis and in vivo validation to establish a robust seven-gene diagnostic signature based on mitochondrial energy metabolism that effectively identifies diabetic nephropathy and elucidates its associated immune microenvironment remodeling and signaling pathways.
This study reveals that high-altitude hypoxia induces hippocampal neuronal ferroptosis and cognitive impairment through a self-amplifying axis where mitochondrial damage triggers mtDNA release to activate the cGAS-STING pathway, which interacts with CISD1 to drive ferroptosis, a mechanism validated across mouse models and human cohorts.
This study identifies INHBE, LGALS4, and PPP1R3C as key cholesterol metabolism-related diagnostic biomarkers and therapeutic targets for metabolic fatty liver disease (MAFLD) through integrated bioinformatics analysis and in vivo validation in a high-fat diet mouse model.
This study demonstrates that mixing leaf litter from different tree species reshapes phyllosphere microbial communities and exhibits intermediate effects on chemical properties, ultimately influencing litter decomposition rates and nutrient cycling in forest ecosystems.
This preliminary study synthesizes and characterizes an Eggshell/Citric Acid/Chitosan (ES/CA/Cs) nanocomposite as a potential gene delivery carrier, using molecular docking to predict its favorable interaction with the AtRCCR enzyme while highlighting the need for future biological validation to confirm its efficacy in treating renal cell carcinoma.
This study systematically evaluates short-read sequencing, long-read Oxford Nanopore Technologies, and EPICv2 microarrays for brain tumor profiling, concluding that while short-read sequencing offers superior scalability and accuracy for somatic variants, long-read sequencing provides unique advantages in resolving problematic genomic regions and haplotype-specific methylation, with all platforms demonstrating high concordance in methylation measurements.
This study demonstrates that eliciting suspension cultures of *Picrorhiza kurroa* with mycelial extracts from endophytic fungi, particularly *Fusarium acuminatum* (EE2), significantly enhances the concentration-dependent and tissue-specific production of valuable picrosides and their precursors.
This study employs an explainable machine learning framework to identify distinct, multidimensional factors driving accelerated biological ageing in breast cancer survivors compared to cancer-free women, revealing unique associations such as impaired functional status and radiotherapy in survivors versus physical fitness and diet in controls, thereby paving the way for targeted survivorship care.
Using a novel four-arm mouse model with independent ablation and transplantation branches, this study demonstrates that antibiotic-mediated gut microbiota depletion specifically eliminates secondary bile acids and drives a pro-inflammatory cytokine shift in BCG-infected mice, establishing a direct link between the gut community, its metabolites, and the host immune response.
This study demonstrates that eDNA-qPCR significantly outperforms conventional larval surveys for detecting *Aedes albopictus* under tropical field conditions on La Réunion island, showing a strong correlation between signal intensity and larval density while remaining effective despite environmental factors like sun exposure.