🧬 Category

q-bio

3677 papers

🧬 biology

The Changing Landscape of Genetic Risk: Age-Related Effects of Polygenic Scores for Suicidal Behaviors

This study of the Add Health cohort reveals that polygenic risk scores for suicidal ideation and attempts show modest but significant associations with outcomes only in young adulthood and early mid-life, rather than adolescence, suggesting that current genetic risk models based on adult data may not capture developmental-specific risks and highlighting the need for age-stratified genome-wide association studies to improve targeted prevention strategies.

Nathan Gillespie, Severine Lannoy, Mallory Stephenson, Robert Kirkpatrick, Zuriel Ceja, Miguel Renteria, Alexis C. Edwar (…)2026-09-17
🧬 biology

Lactylation of histone variant MacroH2A1 at K134 regulates osteogenic differentiation of bone marrow mesenchymal stem cells

This study reveals that lactylation of the histone variant MacroH2A1 at lysine 134 epigenetically suppresses osteogenic differentiation of bone marrow mesenchymal stem cells by restricting chromatin accessibility, and that blocking this modification restores bone mass in osteoporotic mice, identifying it as a novel therapeutic target for osteoporosis.

Jianyun Liu, Baicheng Ma, Xingnuan Li, Kai Long, Shan He, Ping Wu, Xiaoyuan Xu, Ling Long, Tao Wang, Jianjun Xiong2026-09-17
🧬 biology

EDTA preserves high molecular weight DNA across tissues of diverse species stored at room temperature for more than five years

This study demonstrates that long-term room-temperature storage of diverse tissue samples in EDTA preserves high molecular weight DNA more effectively than ethanol or fresh extraction, despite causing some tissue dissolution, while also revealing that the EDTA supernatant itself serves as a valuable source of recoverable genomic DNA.

Molly Johnson, Mia L. DeSanctis, Ella Messner, Eris Niles, Elizabeth A. Soranno, Hannah J. Appiah-Madson, Rosalia Falco (…)2026-09-17
🧬 biology

BiP Regulates the Unfolded Protein Response and Mitochondrial Respiration in Human Embryonic Stem Cells

This study demonstrates that while the ER chaperone BiP is dispensable for maintaining pluripotency in human embryonic stem cells, it is essential for coordinating the unfolded protein response with mitochondrial respiration to ensure stress resilience and prevent dissociation-induced apoptosis.

Shahnaz Babaei Abraki, Athaliah Gervacio, Iman Al Khatib, Timothy E. Shutt, Derrick E. Rancourt2026-09-17
🧬 biology

Complete Mitochondrial Genome and Protein-Coding Gene Evolution of Naemorhedus goral in Wanglang National Nature Reserve

This study presents the complete mitochondrial genome of a *Naemorhedus goral* from Wanglang National Nature Reserve, detailing its structural features, codon usage patterns, and evolutionary characteristics of protein-coding genes to provide an independently archived sequence for comparative analysis within the Caprinae subfamily.

Xiao Min, Zhang Jingjing, Dai Yuxin, Mu Sijing, Huang Junzhong, Zhao Lianjun, Liu Hao, Hua Donglai2026-09-17
🧬 biology

Moderate drought and lignin biosynthesis orchestrate tuberous root formation in Potentilla anserina via PaCCR1-mediated sucrose allocation

Moderate drought triggers tuberous root formation in *Potentilla anserina* by downregulating the PaCCR1-mediated lignin biosynthesis pathway, thereby redirecting carbon flux from structural lignin production to soluble sugar and starch accumulation to facilitate radial root expansion.

Mi Zhou, Yuxin Wang, Yangyang Xie, Meng Zhang, Tao Yang, Jinzhu Zhang, Wuhua Zhang, Jie Dong2026-09-17
🧬 biology

Whole-genome resequencing reveals population genomic diversity and enables SNP fingerprinting for germplasm management in Saudi Arabian pearl millet (Pennisetum glaucum)

This study utilizes whole-genome resequencing of 49 Saudi Arabian pearl millet accessions to characterize their population structure and genetic diversity, ultimately developing a highly discriminating 150-SNP fingerprinting panel integrated with QR-code technology for effective digital germplasm management.

Naser B Almarri, Salwa M Mostafa, Sara Osman, Sara M Alomran, Mohanad A Ibrahim, Ibrahim Alrashidi, Omar A Al-Haidar, Ib (…)2026-09-17
🧬 biology

Whole-Transcriptome Profiling Reveals RNA Expression Dynamics and ceRNA Network Remodeling across Health, Sepsis, and Sepsis-Associated Acute Respiratory Distress Syndrome

This study utilizes whole-transcriptome sequencing of peripheral blood to characterize progressive dysregulation of mRNAs, lncRNAs, circRNAs, and miRNAs across health, sepsis, and sepsis-associated ARDS, revealing a remodeled ceRNA network that drives immune-inflammatory activation, extracellular matrix remodeling, and barrier dysfunction.

Qicheng Long, Yongkang Ye, Aifang Huang, Shuqing Liang, Wei Wang2026-09-17
🧬 biology

Performance of Polygenic Risk Scores for Breast Cancer in African Populations: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis reveals that while polygenic risk scores for breast cancer show modest predictive performance in African populations, European-derived models currently outperform those developed specifically for African ancestry, underscoring the critical need for greater genomic representation and recalibration to improve clinical utility.

RISSAME Djeneba Yasmina, Abibou SIMPORE, ZOURE Abdou Azaque, Barro Marcus, Moussa OUATTARA, Aida Djé Traoré, SAWADOGO Mo (…)2026-09-17