1390 papers
This study documents 93 Chlorophyta taxa from nine streams in western Paraná, Brazil, including 32 new records for the region and nine new records for the country, thereby significantly expanding the known green algal flora of the area.
This study demonstrates that data source heterogeneity, rather than algorithm choice, is the primary driver of performance gaps in QSAR models for mutagenicity, necessitating a shift toward source-aware evaluation standards to ensure reliable regulatory risk assessment.
This study demonstrates that crude lychee seed extract, rich in phenolics and flavonoids, is non-cytotoxic to human gingival fibroblasts at concentrations up to 50 µg/mL and significantly enhances cell proliferation and migration in a concentration-dependent manner, suggesting its potential as a therapeutic agent for promoting oral wound healing.
This study demonstrates that while gradient-based optimizers excel in noiseless simulations, population-based strategies like CMA-ES are significantly more robust against finite-shot sampling noise in Variational Hamiltonian Ansatz calculations, and that high-shot reevaluation can effectively mitigate sampling-induced fluctuations to recover accurate energy estimates.
This study demonstrates that coinfection of *Ixodes ricinus* ticks with specific bacterial species differentially modulates Tick-borne encephalitis virus (TBEV) replication and triggers distinct, species-specific activation patterns of the Toll, IMD, and JAK/STAT immune signaling pathways.
This study demonstrates that a "Tag-and-Trigger" paradigm, which combines spatial learning with precisely timed basolateral amygdala stimulation, rescues memory deficits, restores synaptic plasticity, and reverses Alzheimer's pathology in 5XFAD mice by leveraging activity-dependent mechanisms to reinforce specific hippocampal-cortical circuits.
This study presents the first high-quality, de novo reference genome for the economically and ecologically vital Argentine hake (*Merluccius hubbsi*), which not only elucidates its evolutionary history and demographic fluctuations but also confirms its current robust genetic diversity and lack of recent inbreeding despite historical climate changes and intense fishing pressure.
This study identifies the m6A reader IGF2BP2 as a critical regulator of the HMGA2/FOSL1 axis that drives the adrenergic-to-mesenchymal transition, chromatin remodeling, and therapy resistance in high-risk neuroblastoma, thereby revealing epitranscriptomic and transcriptional vulnerabilities for therapeutic intervention.
This study analyzed 125 culture-confirmed *Vibrio cholerae* isolates from Ethiopian cholera outbreaks using multiplex PCR and found that all nine targeted virulence-associated genes were present across the isolates, with *hlyA* being the most prevalent, thereby highlighting the significant pathogenic potential of circulating strains and establishing a molecular baseline for future epidemiological research in the region.
This study demonstrates that delivering a stabilizing nanobody (T2a) via mRNA lipid nanoparticles corrects F508del-CFTR trafficking and reveals a novel, non-canonical open-channel conformation, offering a new therapeutic paradigm for cystic fibrosis and other protein misfolding diseases.