🧠 Category

neurology

231 papers

Meta analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS Reveals emergence of adaptive brain glucometabolic responses and associated neurological functional profiles

This meta-analysis of 130 FDG-PET studies involving over 8,900 participants reveals that dysregulated glucose metabolism, characterized by both disease-specific hypo- and hypermetabolic patterns, is a unifying feature of late-onset age-associated neurodegenerative diseases that reflects complex adaptive neural bioenergetic remodeling.

Raikes, A. C., Garza, M., Murrell, A. N. + 1 more2026-04-08🧠 neurology

Normative Modelling of Brain Volume in Multiple Sclerosis

This study demonstrates that normative modelling of brain volume using a large healthy reference cohort reveals heterogeneous, deep grey matter-centric atrophy patterns in multiple sclerosis patients that are significantly associated with disability accumulation, supporting the use of population-referenced MRI metrics for individualized phenotyping and risk stratification.

Korbmacher, M., Lie, I. A., Wesnes, K. + 10 more2026-04-07🧠 neurology

Automated Sleep Stage and Event Detection Algorithms Using Quality-Controlled PSG Annotations

This study demonstrates that machine-learning models trained on quality-controlled, consensus-based polysomnography annotations achieve performance comparable to human inter-scorer agreement for sleep stage and arousal detection, while highlighting the critical role of annotation consistency in developing reliable automated sleep analysis systems.

Kaneda, M., Ogaki, S., Nohara, T. + 5 more2026-04-07🧠 neurology

Connectomics-guided meta-learning for decoding and anticipatory prediction of sleep spindles from basal ganglia local field potentials in Parkinson's disease

This study presents a connectomics-guided meta-learning framework that successfully decodes and anticipates sleep spindles from basal ganglia local field potentials in Parkinson's disease patients, establishing a critical foundation for sleep-targeted closed-loop deep brain stimulation to address non-motor symptoms.

Ye, C., Liao, J., Yin, Z. + 5 more2026-04-07🧠 neurology

Toward clinical implementation of a metabolic blood biomarker for Parkinson's disease differential diagnosis

This study demonstrates that a previously patented 6-metabolite blood biomarker, successfully adapted to a standardized automated NMR platform and enhanced by adding VLDL-5 free cholesterol and citrate, achieves high accuracy in the differential diagnosis of Parkinson's disease from atypical parkinsonian syndromes and Alzheimer's disease, supporting its readiness for clinical implementation.

Millasseau, V., Mallet, D., Carnicella, S. + 7 more2026-04-07🧠 neurology

9.4 Tesla MRI in focal epilepsy patients with high-resolution surface-based profiling of focal cortical dysplasias

This study demonstrates that while 9.4T MRI did not reveal new epileptogenic lesions in drug-resistant focal epilepsy patients with negative 3T scans, its high-resolution T2*-weighted imaging enabled the quantitative profiling of the "black line sign" in focal cortical dysplasias, offering potential benefits for refining surgical targeting.

Kronlage, C., Martin, P., Bender, B. + 10 more2026-04-07🧠 neurology

The Gut-Vascular Axis in Intracranial Aneurysm Rupture: A Systematic Review and Meta-analysis of Human Microbiome Evidence

This systematic review and meta-analysis synthesizes human evidence to suggest that gut microbiome dysbiosis, characterized by reduced alpha diversity and specific microbial taxa alterations, is associated with intracranial aneurysm rupture and vascular inflammation, though further prospective research is needed to establish causality and clinical utility.

Fahim, F., Hemmati, M., Heshmaty, S. + 14 more2026-04-07🧠 neurology

Platelet Function Test-Guided Antiplatelet Therapy Reduces Recurrent Stroke in Atherothrombotic and Lacunar Infarction

This retrospective study of Japanese patients with atherothrombotic or lacunar infarction found that antiplatelet therapy guided by VerifyNow platelet function testing significantly reduced the risk of recurrent ischemic stroke without increasing hemorrhagic risk compared to empirically selected therapy, though the findings require validation in larger randomized trials.

Nakayasu, S., Hayashi, H., Goda, R. + 6 more2026-04-07🧠 neurology

From Bedside to Bench: Drosophila Models of Baker-Gordon Syndrome (BAGOS)

This study utilizes *Drosophila* models to demonstrate that the SYT1 D310N variant causes a more severe Baker-Gordon syndrome phenotype than D366E through variant-specific synaptic vesicle recycling defects and developmental disruption of cholinergic and GABAergic circuits, revealing that the disease arises from early developmental network alterations rather than solely from adult synaptic transmission failures.

Rivera, C. E., Park, J., Holder, B. L. + 9 more2026-04-06🧠 neurology

Obstructive Sleep Apnea is Associated with Peri-Lead Edema Following Deep Brain Stimulation for Parkinson's Disease

This retrospective case-control study of 121 Parkinson's disease patients undergoing deep brain stimulation reveals that obstructive sleep apnea and perioperative hypoxemia are significantly associated with an increased risk and severity of symptomatic peri-lead edema, whereas REM sleep behavior disorder appears to be protective.

Kornilov, E., Alkan, U., Harari, E. + 9 more2026-04-06🧠 neurology

Hierarchical Barycentric Multimodal Representation Learning for Medical Image Analysis

This paper introduces a theoretically grounded framework for multimodal medical image analysis that utilizes hierarchical Wasserstein barycenters to learn robust, generalizable representations by preserving unimodal geometry and effectively handling missing modalities, thereby outperforming existing methods in brain tumor segmentation and normative modeling tasks.

Qiu, P., An, Z., Ha, S. + 3 more2026-04-06🧠 neurology

Theta-Range SEEG Stimulation for Temporal Lobe Mapping: An Alternative to Conventional 1-Hz and 50-Hz Protocols

This study demonstrates that theta-range (7 Hz) electrical brain stimulation during SEEG mapping elicits higher rates of epileptic afterdischarges and clinical signs in the temporal lobe compared to conventional 1-Hz protocols, suggesting that incorporating physiologically relevant frequencies could improve the accuracy of epileptic network identification.

Darves-Bornoz, A., Barbeau, E. J., Denuelle, M. + 7 more2026-04-05🧠 neurology

Trends in thiamine treatment patterns for Wernicke encephalopathy in Japan for 2010-2023: A nationwide descriptive study

This nationwide descriptive study of 7,856 Japanese patients with Wernicke encephalopathy from 2010 to 2023 reveals a significant shift toward high-dose thiamine treatment over time, yet highlights that despite early intervention and low in-hospital mortality, a substantial proportion of patients still experience functional impairment at discharge, underscoring the need for further research on optimal dosing and prevention.

Yamagata, N., Kimura, Y., Matsui, H. + 1 more2026-04-04🧠 neurology