195 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This study demonstrates that in patients with established multiple sclerosis, routine whole-brain MRI sequences (fs-FLAIR and DIR) perform comparably to dedicated orbital sequences (STIR) for detecting optic nerve lesions, supporting the omission of additional orbital scans to reduce scan time and patient burden without compromising diagnostic sensitivity.
This multi-stakeholder focus group study reveals that while non-invasive brain stimulation (NIBS) is viewed with cautious optimism by patients, clinicians, and researchers, its clinical translation is currently hindered by barriers such as limited awareness, infrastructure constraints, regulatory uncertainty, and challenges in demonstrating cost-effectiveness, necessitating improved communication, education, and collaboration to facilitate adoption.
This study demonstrates that the observed correlation between rest tremor and ipsilateral dopamine transporter binding in Parkinson's disease likely reflects a distinct global pattern of dopaminergic degeneration rather than a specific, dose-dependent pathophysiological mechanism linking tremor amplitude to ipsilateral function.
This study identifies the VPS35 p.A320V variant as a co-segregating factor in a pesticide-exposed family with Parkinson's disease, yet notes that unlike the known pathogenic p.D620N variant, it lacks the characteristic LRRK2 kinase activation and elevated urinary BMP biomarkers, suggesting a more subtle functional impact potentially compounded by environmental exposure.
This retrospective cohort study of Eastern Denmark's population estimates the prevalence of seizure-associated malformations of cortical development at 32.1 per 100,000, providing the first all-age population-based data for these conditions while confirming that overall epilepsy rates align with national figures.
This paper introduces a variational Disease Progression Score framework that leverages multimodal biomarkers and the amyloid cascade hypothesis to generate biologically interpretable, uncertainty-quantified individual prognoses for Alzheimer's disease progression, demonstrating high accuracy and dynamic adaptability on the ADNI cohort.
This study of 2,701 UK Biobank stroke survivors demonstrates that higher polygenic risk scores for coronary artery disease and stroke are independently associated with an increased incidence of major adverse cardiovascular events and recurrent stroke, partly mediated by poorer control of glycemic and lipid risk factors.
This study demonstrates that impaired temporal coupling between cortical blood flow and cerebrospinal fluid inflow, a marker of glymphatic function, is associated with specific non-motor symptoms such as hallucinations, cognitive fluctuations, and sleep disturbances in patients with Lewy body disorders, rather than with motor symptom severity.
This prospective study comparing patients with persistent post-COVID-19 neurological symptoms to fully recovered controls found no evidence of ongoing adaptive CNS immune activation, intrathecal SARS-CoV-2-specific responses, or disease-specific neuronal autoimmunity, suggesting that routine CSF analysis is unlikely to yield specific biomarkers for these symptoms.
This study presents the first-in-human demonstration that device-embedded inertial sensors can effectively detect walking states to trigger adaptive deep brain stimulation, thereby improving gait measures in a Parkinson's disease patient compared to traditional open-loop stimulation.