193 papers
This study demonstrates that individuals with spinal cord injury exhibit impaired homeostatic regulation of corticomotor excitability, characterized by a failure to suppress excessive plasticity following repeated excitatory brain stimulation, which may underlie persistent complications like neuropathic pain.
This study utilizes neurite orientation dispersion and density imaging (NODDI) to reveal phenotype-specific white matter microstructural disruptions in Wilson disease, characterized by reduced axonal density and fiber organization in neurological cases and excess free water in hepatic cases, which correlate with specific neurological and cognitive impairments.
This study demonstrates a causal modeling approach that translates short-term changes in Parkinson's disease rating scales into long-term predictions of clinically meaningful outcomes, showing that a 30% reduction in disease progression could significantly lower the 10-year risk of dementia, falls, and mortality.
This study suggests that bilingualism may support cognitive reserve in both amnestic Alzheimer's disease and logopenic variant primary progressive aphasia, allowing bilinguals to maintain comparable cognitive performance to monolinguals despite exhibiting reduced gray matter volume in specific regions, with bilinguals in the logopenic variant additionally showing preserved volume in disease-epicenter areas.
This bibliometric analysis of 403 publications from the past two decades reveals that neuroendoscopy for intracranial hemorrhage has evolved from a focus on operative feasibility and safety to a precision-based, minimally invasive cornerstone of treatment, driven primarily by Chinese and American research and increasingly integrated with emerging technologies like augmented reality and robotics.
The Global Parkinson's Genetics Program (GP2) identifies a significant global population of 9,019 potentially trial-eligible carriers of pathogenic *GBA1* and *LRRK2* variants among 65,509 Parkinson's disease patients, highlighting a critical disparity between these genetic carriers and the availability of gene-targeted clinical trials while advocating for a unified framework to enable equitable precision medicine recruitment.
In a retrospective cohort study of 130 spinal cord stroke patients, initial injury severity was the strongest predictor of functional outcomes, while corticosteroid treatment was significantly associated with improved ambulatory status and modified Japanese Orthopedic Association scores.
This long-term prospective study of 130 post-H1N1 narcolepsy type 1 patients reveals that while baseline phenotype severity is the strongest predictor of long-term outcomes, individuals associated with Pandemrix vaccination initially present with more severe symptoms but demonstrate greater long-term improvement compared to unvaccinated cases.
By applying computational modeling to intracranial EEG data, this study reveals that distinct, preconfigured excitation-inhibition dynamics underlie clinically defined seizure onset patterns, offering a mechanism-informed classification that correlates with patient characteristics and surgical outcomes.
Despite employing rigorous machine learning methods on a large cohort of chronic subdural hematoma patients, this study concludes that routinely available clinical and radiographic variables lack sufficient predictive power to enable clinically actionable risk stratification for surgical recurrence, thereby supporting the maintenance of uniform or symptom-driven surveillance protocols rather than risk-based approaches.
This study utilizes fNIRS to demonstrate that the functional maturation of the infant prefrontal cortex (ages 1–8 months) is characterized by state-dependent developmental tuning of network fluctuation dynamics, where auditory stimulation and age differentially modulate the intensity and frequency distribution of functional connectivity fluctuations during sleep and stimulation.
This study demonstrates that visual quality of life in Parkinson's disease is strongly predicted by objective measures of convergence insufficiency and oculomotor instability, which correlate significantly with patient-reported symptoms and are best captured through a combination of clinical exams and eye tracking.
This observational and genetic study demonstrates that H-type hypertension, defined as the combination of hypertension and hyperhomocysteinemia, independently predicts aneurysmal wall enhancement and growth in unruptured intracranial aneurysms, likely driven by inflammatory and extracellular matrix remodeling pathways.
This study demonstrates that plasma pTau217 serves as a robust prognostic, monitoring, and risk-stratification biomarker in Lewy body disease, where higher baseline levels and faster longitudinal increases predict accelerated cognitive and functional decline as well as a three-fold increased risk of progression to MCI or dementia.
In a cross-sectional study of older African Americans without dementia, higher plasmalogen biosynthesis values were suggestively associated with better global cognitive function and lower levels of white matter hyperintensities, though these findings require validation in larger, longitudinal cohorts.
This retrospective study of 90 participants reveals that, contrary to the initial hypothesis linking migraine frequency to increased perivascular space (PVS) burden, migraineurs actually exhibited significantly lower PVS volumes and cluster counts compared to healthy controls, with the most pronounced reductions observed in individuals with aura, suggesting that aura rather than the disorder itself drives these glymphatic system alterations.
This study demonstrates that a connectome-guided algorithm can identify deep brain stimulation settings distinct from standard clinical parameters to specifically target brain circuits associated with gait dysfunction, resulting in improved gait outcomes for Parkinson's disease patients.
This multicenter retrospective study of 3,353 brain donors across 11 global brain banks reveals that misdiagnosis rates for parkinsonian disorders range from 10% to 20%, with significant associations found between specific genetic variants (GBA1, LRRK2), ancestry (South Asian and Ashkenazi Jewish), and distinct pathological burdens, underscoring the critical need for biologically informed diagnostic tools and genetically stratified approaches in future therapeutic trials.
This study demonstrates that patients with Functional Motor Disorder exhibit distinct oculomotor abnormalities, including increased saccade errors, altered blink patterns, and reduced pupil dilation velocity, which are linked to symptom severity and support neurobiological models involving altered predictive and attentional processing in the frontal cortex and basal ganglia.
This study demonstrates that a higher baseline neutrophil-to-lymphocyte ratio (NLR) serves as a predictive biomarker for the development and persistence of infusion-site skin nodules in Parkinson's disease patients receiving foslevodopa/foscarbidopa subcutaneous infusion, while multidisciplinary surveillance effectively mitigates treatment discontinuation despite these adverse events.