195 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This study demonstrates that active amyloid-beta immunization in the AN1792 trial provided lasting benefits up to 14 years post-treatment by significantly reducing synapse loss, phosphorylated tau accumulation, and astrogliosis around both remaining and newly formed amyloid plaques in Alzheimer's disease patients.
This longitudinal N-of-1 study demonstrates that in Long COVID with dysautonomia, the quality of block-level deep sleep consolidation is a significantly stronger predictor of next-day wellbeing than total sleep duration, with space weather acting as an environmental modifier that degrades sleep architecture and immune flares serving as an independent architecture-independent confounder.
Using 7T MRI, this study reveals that paramagnetic rim lesions in multiple sclerosis patients exhibit significantly elevated glutamate levels indicative of localized excitotoxic stress, linking lesion-specific glutamatergic dysregulation to neurodegeneration and clinical disability.
This paper introduces BEACON, a biologically constrained continuous-time framework using hierarchical Neural ODEs to accurately forecast long-term cognitive trajectories in Alzheimer's disease by integrating the amyloid-tau-vascular-neurodegeneration-cognition cascade with irregular longitudinal data, thereby ensuring biologically plausible predictions and demonstrating robust generalization and clinical trial enrichment capabilities.
This study aggregates and analyzes 25 years of prion disease literature to quantify the symptomatic course and identify critical data limitations, such as the scarcity of individual patient-level data and disease severity markers, which currently hinder the rational design of pivotal clinical trials.
This study protocol outlines a randomized, sham-controlled trial designed to evaluate the effectiveness and safety of high-intensity interval training, yoga, and intermittent hypoxia-hyperoxia exposure compared to a sham control on cognitive performance and health outcomes in 100 individuals with mild cognitive impairment.
This study reveals substantial biological heterogeneity in Alzheimer's disease by demonstrating that amyloid positivity does not uniformly predict structural neurodegeneration, as evidenced by the fact that 45% of amyloid-positive individuals lack detectable brain atrophy and distinct structural phenotypes map onto unique cognitive profiles.
This translational study integrates clinical observation of a child with CONDSIAS carrying a homozygous p.Thr79Pro ADPRHL2 variant with computational structural analyses to provide preliminary evidence that Minocycline may interact with and influence the conformational stability of ARH3, offering a biologically plausible framework for future therapeutic investigations.
This study introduces a novel longitudinal framework that combines transformer-derived speech representations with clinical history to accurately forecast future MMSE scores, establishing speech as a viable digital biomarker for continuous and early monitoring of cognitive decline in dementia patients.
This mixed-methods study reveals that while average memory decline following temporal lobe epilepsy surgery is generally manageable and integrated into daily life, severe memory decline significantly disrupts identity and autonomy, highlighting an urgent need for improved preoperative counseling and postoperative rehabilitation to better support patient adaptation.