193 papers
This combined TMS and 7T-MRI study demonstrates that in multiple sclerosis patients, cortical lesions within the sensorimotor hand area specifically delay transcallosal conduction toward the lesioned hemisphere, a direction-specific impairment linked to intracortical lesion type rather than white matter microstructural damage.
This RCT-only meta-analysis with Trial Sequential Analysis demonstrates that while ultra-early, short-course tranexamic acid significantly reduces rebleeding without increasing the risk of delayed cerebral ischaemia, no regimen improves mortality or functional outcomes, thereby supporting its selective use as a pre-occlusion bridge while arguing against prolonged treatment.
This population-based study demonstrates that the presence of carotid plaque in middle age is independently associated with a significant decline in non-verbal memory and executive functioning over an 8-year period, suggesting that early detection and intervention of carotid plaque may be crucial for preserving neurological health in later life.
This longitudinal analysis of propensity score-matched cohorts from the Parkinson's Progression Markers Initiative reveals that while alpha-synuclein positive LRRK2-PD patients exhibit milder baseline motor symptoms and dopaminergic deficits compared to sporadic PD, their four-year clinical progression trajectories are statistically similar.
This study utilizes a generalized additive model to demonstrate a robust, non-linear association between historical population exposure to leaded petrol emissions and contemporary motor neuron disease mortality in Australia, independent of secular trends and insecticide use.
This study validates the psychometric properties of the novel UCSF Fein MAC Educational & Developmental History Questionnaire (EDevHx), demonstrating its reliability and validity as a scalable screening tool for capturing early-life learning profiles in cognitively healthy aging adults to better understand their impact on later-life neurodegenerative diseases.
This study demonstrates that using symptom-label permutation as a null model in lesion network mapping preserves anatomical specificity and controls type I error, thereby enabling the reliable identification of distinct brain networks underlying specific neurobehavioural deficits across a large multicenter stroke dataset.
This post hoc analysis of the ORIGINAL clinical trial demonstrates that tenecteplase (0.25 mg/kg) is a safe and effective alternative to alteplase (0.9 mg/kg) for treating patients with minor acute ischemic stroke, showing comparable rates of functional independence at 90 days and no significant differences in safety outcomes.
The CRCS-K Imaging Repository establishes a nationwide, prospective multicenter platform in Korea that integrates comprehensive stroke neuroimaging with AI-based quantification and clinical data, demonstrating the feasibility of large-scale automated analysis to investigate how imaging workflows impact treatment efficiency and patient outcomes.
This patient-specific CFD study reveals that while symptomatic carotid webs exhibit lower time-averaged wall shear stress and higher oscillatory shear index compared to asymptomatic cases, wall-based hemodynamic metrics alone cannot reliably distinguish carotid webs from normal carotid bifurcations.
This prospective cohort study demonstrates that higher pre-stroke physical activity and the Val66Met Val/Val genotype of the BDNF gene are independently associated with better post-stroke cognitive outcomes, although serum BDNF levels did not correlate with either physical activity or genotype.
This study demonstrates that in chronic stroke survivors undergoing high-dose neurorehabilitation, stronger movement-related beta-activity serves as a neurophysiological marker specifically associated with improvements in real-world upper limb activity rather than impairment-level deficits.
This paper presents a machine learning algorithm trained on electronic health records of 1,045 multiple sclerosis patients that accurately predicts new MRI lesions to help clinicians personalize the frequency of disease surveillance imaging.
This study utilizing data from the AcT trial found that while the EQ-5D-5L exhibits statistically significant but practically negligible age-related differential item functioning in physical domains, it functions equivalently across sex and treatment groups, supporting its validity for health-related quality of life comparisons in acute ischemic stroke trials.
This meta-analysis indicates that while gross total resection significantly improves overall survival for low-grade intramedullary spinal gliomas, it offers no survival benefit for high-grade lesions, and the addition of radiotherapy is associated with worse outcomes in low-grade tumors.
This study demonstrates that tinnitus is significantly more prevalent in individuals with Functional Neurological Disorder (FND) than in controls and exhibits similar attention-dependent characteristics, suggesting it should be recognized as a potential symptom of FND arising from shared underlying mechanisms.
This study identifies distinct peripheral blood immune signatures in primary tauopathy patients, revealing that a dysregulated axis characterized by impaired monocyte maturation and reduced Treg activity correlates with increased neurodegeneration, cognitive decline, and poorer prognosis, suggesting these cell subsets as potential biomarkers and therapeutic targets.
This study presents a variational autoencoder (VAE) framework that enhances the resolution and reproducibility of gut microbiome enterotyping in Parkinson's disease by linking unsupervised community typing with supervised disease prediction, revealing that while three distinct microbiome configurations are robustly identifiable across cohorts, they do not independently serve as biomarkers for PD status.
This study suggests that females' inherent verbal memory advantages may mask early Alzheimer's symptoms, leading to a delayed onset of cognitive decline despite amyloid pathology, which ultimately results in a steeper decline once dementia manifests and highlights a critical window for earlier detection and intervention.
This paper outlines the statistical analysis plan for the AVERT-DOSE trial, a Phase 3 multi-arm, multi-stage, response-adaptive randomized study designed to identify the optimal early mobility training regimen for stroke patients.