193 papers
This secondary analysis of the ATACH-2 trial demonstrates that early post-ICH hyperglycemia is significantly associated with poor functional outcomes, while late and persistent hyperglycemia are linked to worse survival rates, highlighting the prognostic value of continuous glucose monitoring and trajectory-based glycemic control strategies.
This study demonstrates that combining standardized upper-limb tasks with interpretable sEMG feature analysis significantly improves the classification of early-stage Parkinson's disease by capturing complementary motor impairments related to bradykinesia, rigidity, and tremor.
Using precision fMRI in individuals with chronic aphasia, this study demonstrates that language comprehension relies on the integrity and activity of the specialized language network rather than on functional remapping or recruitment of the Multiple Demand network.
This study demonstrates that ischaemic stroke survivors exhibit significant, dynamic, and region-specific reductions in MRI-detected perivascular space volume and cluster counts compared to healthy controls by 36 months post-stroke, suggesting a potential link between stroke and altered cerebral small vessel disease markers over time.
This longitudinal study demonstrates that obstructive sleep apnea is associated with enlarged MRI-visible perivascular spaces, which show a trend toward normalization and reduced statistical significance between patients and controls after 12 months of CPAP therapy, suggesting potential regional reversibility of this brain fluid transport marker.
This study of 16,270 participants from the All of Us database reveals that severe survey-reported hearing loss and sensorineural hearing loss are strongly associated with dementia, exhibiting higher odds ratios than other established risk factors such as smoking, parental hearing loss, and hypertension.
This study identifies the upregulation of the DDR2 receptor in specific brain cells as a key driver of Alzheimer's disease neurovascular dysfunction and demonstrates that a brain-persistent antibody targeting DDR2 for degradation restores fluid dynamics and metabolic clearance, thereby reversing pathologies and rescuing cognitive deficits in mouse models.
By applying SuStaIn modeling to post-mortem spinal cord transcriptomics, this study deciphers the temporal dynamics of amyotrophic lateral sclerosis (ALS) to identify two distinct molecular subtypes with unique progression trajectories and therapeutic vulnerabilities, thereby establishing a framework to overcome the limitations of cross-sectional data in neurodegenerative research.
This study demonstrates that a single dose of atomoxetine preserves short-term heart rate variability in Parkinson's disease patients, supporting its cardiovascular safety and viability as a treatment for neuropsychiatric symptoms.
This study demonstrates that a serum panel combining neuronal injury markers, Wnt signaling dysregulators, and amyloid pathology effectively diagnoses Parkinson's disease and predicts the severity of its motor, psychiatric, and chronic fatigue symptoms, suggesting these pathways as potential therapeutic targets.
This multicenter study demonstrates that an AI-based algorithm accurately detects and quantifies hemorrhagic transformation across multiple imaging modalities following endovascular thrombectomy, showing high sensitivity and a strong dose-response correlation with 3-month functional outcomes that surpasses traditional categorical grading.
The paper introduces AutoML-Multiverse, an instability-aware framework that systematically quantifies analytic variability by evaluating approximately 20,000 machine learning pipelines across diverse Alzheimer's disease cohorts, demonstrating that accounting for analytic choices significantly improves model robustness and reveals critical limitations in the generalizability of single-cohort studies.
This study demonstrates that a robust linear regression model can accurately estimate monopolar local field potential power from bipolar recordings in deep brain stimulation, offering a hardware-agnostic solution to improve spatial signal resolution for adaptive therapy.
This study demonstrates that motor imagery engages distinct motor cortical representations compared to both active and passive movements due to differences in limb state and proprioceptive feedback, indicating that decoders trained on one condition do not generalize to the others and highlighting the need for tailored designs in brain-computer interface applications.
This systematic review and meta-analysis comparing titanium and PEEK cranioplasty materials concludes that while titanium offers superior operative efficiency and a lower risk of postoperative infection, PEEK demonstrates lower exposure rates, suggesting that implant selection should be tailored to individual patient factors and surgical expertise.
This study validates the PainWaive, a consumer-grade 2-channel EEG headset, as a reliable tool for remote neurofeedback and chronic pain monitoring by demonstrating its strong agreement with research-grade equipment across various frequency bands and its stability in real-world home-based clinical applications.
Using real-world data from the ALS Natural History Study and a causal inference framework that accounts for selection bias and loss to follow-up, this study confirms the prognostic impact of baseline function on survival while finding no statistically significant evidence that sex or metformin use influences survival outcomes in ALS patients.
In a pragmatic randomized controlled trial involving 470 people with multiple sclerosis and impaired quality of life, the digital therapeutic levidex, when added to standard care, significantly improved disease-specific quality of life, depressive symptoms, and social functioning compared to standard care alone.
By employing high-resolution single-cell multi-omic profiling in over 100 patients, this study reveals that Alzheimer's Disease progression is characterized by distinct peripheral immune dysregulations, including impaired B cell activation and NF-kB/AP-1-driven monocyte inflammation, which differentiate the disease trajectory from healthy aging.
This study demonstrates that additional vascular brain injury significantly modifies the relationships between sleep duration, white matter hyperintensity burden, and cognition across the Alzheimer's disease continuum, underscoring the need to consider comorbid cerebrovascular pathology beyond white matter hyperintensities alone.