228 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This study demonstrates that impaired temporal coupling between cortical blood flow and cerebrospinal fluid inflow, a marker of glymphatic function, is associated with specific non-motor symptoms such as hallucinations, cognitive fluctuations, and sleep disturbances in patients with Lewy body disorders, rather than with motor symptom severity.
This prospective study comparing patients with persistent post-COVID-19 neurological symptoms to fully recovered controls found no evidence of ongoing adaptive CNS immune activation, intrathecal SARS-CoV-2-specific responses, or disease-specific neuronal autoimmunity, suggesting that routine CSF analysis is unlikely to yield specific biomarkers for these symptoms.
This study presents the first-in-human demonstration that device-embedded inertial sensors can effectively detect walking states to trigger adaptive deep brain stimulation, thereby improving gait measures in a Parkinson's disease patient compared to traditional open-loop stimulation.
This study demonstrates that active amyloid-beta immunization in the AN1792 trial provided lasting benefits up to 14 years post-treatment by significantly reducing synapse loss, phosphorylated tau accumulation, and astrogliosis around both remaining and newly formed amyloid plaques in Alzheimer's disease patients.
This longitudinal N-of-1 study demonstrates that in Long COVID with dysautonomia, the quality of block-level deep sleep consolidation is a significantly stronger predictor of next-day wellbeing than total sleep duration, with space weather acting as an environmental modifier that degrades sleep architecture and immune flares serving as an independent architecture-independent confounder.
Using 7T MRI, this study reveals that paramagnetic rim lesions in multiple sclerosis patients exhibit significantly elevated glutamate levels indicative of localized excitotoxic stress, linking lesion-specific glutamatergic dysregulation to neurodegeneration and clinical disability.
This paper introduces BEACON, a biologically constrained continuous-time framework using hierarchical Neural ODEs to accurately forecast long-term cognitive trajectories in Alzheimer's disease by integrating the amyloid-tau-vascular-neurodegeneration-cognition cascade with irregular longitudinal data, thereby ensuring biologically plausible predictions and demonstrating robust generalization and clinical trial enrichment capabilities.
This study aggregates and analyzes 25 years of prion disease literature to quantify the symptomatic course and identify critical data limitations, such as the scarcity of individual patient-level data and disease severity markers, which currently hinder the rational design of pivotal clinical trials.
This study protocol outlines a randomized, sham-controlled trial designed to evaluate the effectiveness and safety of high-intensity interval training, yoga, and intermittent hypoxia-hyperoxia exposure compared to a sham control on cognitive performance and health outcomes in 100 individuals with mild cognitive impairment.
This study reveals substantial biological heterogeneity in Alzheimer's disease by demonstrating that amyloid positivity does not uniformly predict structural neurodegeneration, as evidenced by the fact that 45% of amyloid-positive individuals lack detectable brain atrophy and distinct structural phenotypes map onto unique cognitive profiles.