98 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This study demonstrates that combining standardized upper-limb tasks with interpretable sEMG feature analysis significantly improves the classification of early-stage Parkinson's disease by capturing complementary motor impairments related to bradykinesia, rigidity, and tremor.
This study demonstrates that ischaemic stroke survivors exhibit significant, dynamic, and region-specific reductions in MRI-detected perivascular space volume and cluster counts compared to healthy controls by 36 months post-stroke, suggesting a potential link between stroke and altered cerebral small vessel disease markers over time.
This longitudinal study demonstrates that obstructive sleep apnea is associated with enlarged MRI-visible perivascular spaces, which show a trend toward normalization and reduced statistical significance between patients and controls after 12 months of CPAP therapy, suggesting potential regional reversibility of this brain fluid transport marker.
This study identifies the upregulation of the DDR2 receptor in specific brain cells as a key driver of Alzheimer's disease neurovascular dysfunction and demonstrates that a brain-persistent antibody targeting DDR2 for degradation restores fluid dynamics and metabolic clearance, thereby reversing pathologies and rescuing cognitive deficits in mouse models.
This study demonstrates that a single dose of atomoxetine preserves short-term heart rate variability in Parkinson's disease patients, supporting its cardiovascular safety and viability as a treatment for neuropsychiatric symptoms.
This study utilizes unsupervised clustering of clinical data from 865 Tourette Disorder patients to identify five distinct, clinically relevant subtypes characterized by specific comorbidities and demographics, aiming to improve diagnostics, treatment, and the understanding of genetic etiologies.
This systematic review and meta-analysis comparing titanium and PEEK cranioplasty materials concludes that while titanium offers superior operative efficiency and a lower risk of postoperative infection, PEEK demonstrates lower exposure rates, suggesting that implant selection should be tailored to individual patient factors and surgical expertise.
In a pragmatic randomized controlled trial involving 470 people with multiple sclerosis and impaired quality of life, the digital therapeutic levidex, when added to standard care, significantly improved disease-specific quality of life, depressive symptoms, and social functioning compared to standard care alone.
By integrating post-mortem tissue data, in vivo PET imaging, and kinetic modeling, this study reveals that a profound defect in vesicular dopamine storage, rather than just synthesis or release, is the primary cause of dopamine depletion in the residual terminals of Parkinson's disease patients.
This study demonstrates that transcranial electrical stimulation with temporal interference (TES-TI) targeting the thalamus at a fixed 10 Hz difference frequency significantly enhances sleep spindle activity and sigma band power during daytime naps, outperforming both individually matched frequency and stimulation without a difference frequency.