40 papers
Endocrinology explores the complex network of hormones that regulate nearly every function in the human body, from metabolism and growth to mood and reproduction. When this delicate chemical signaling system falters, it can lead to a wide range of conditions, including diabetes, thyroid disorders, and fertility issues. Understanding these mechanisms is vital for developing treatments that restore balance and improve quality of life.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category as it becomes available, transforming dense medical findings into clear, plain-language overviews alongside detailed technical summaries. This approach ensures that both curious readers and specialists can stay informed without getting lost in jargon.
Below are the latest endocrinology preprints we have processed, offering fresh insights into how our internal chemistry shapes health and disease.
This study utilizes network analysis on 1,286 women with polycystic ovary syndrome (PCOS) to reconstruct an integrated endocrine-metabolic biomarker network, identifying sex hormone-binding globulin and other key bridge biomarkers that link distinct physiological domains and offer new insights for precision medicine.
This study integrates human bulk transcriptomics with mouse spatial transcriptomics to define distinct stromal niches driving intermuscular adipose expansion in metabolic disease, revealing that EBF2-mediated lineage plasticity, rather than progenitor abundance, orchestrates this spatially organized remodeling.
This study utilizes an explainable LightGBM framework integrated with diverse public data sources to accurately predict and geographically interpret county-level diagnosed diabetes prevalence across the United States, identifying poverty and food insecurity as dominant structural drivers while emphasizing that the resulting insights serve as model-based explanations rather than causal effects.
In a prospective cohort study of 2,024 Japanese patients with diabetes, higher visceral adipose tissue was found to increase cancer risk while greater handgrip strength offered protection against cardiovascular events, though neither body composition, daily physical activity, nor handgrip strength were independently associated with all-cause mortality.
This study presents a mechanistic model of bone cell population dynamics that integrates key regulatory pathways and 22 genetic variants to simulate postmenopausal bone loss trajectories, successfully capturing clinical trends and identifying specific genetic risk factors and ancestry-related differences in bone density decline.
This cross-sectional study of 508 participants reveals that circulating CtBP2 levels exhibit weak but statistically significant positive associations with measures of adiposity, particularly abdominal fat, but show no significant correlation with lipid profile abnormalities.
This hospital-based multicentre cross-sectional study in Bangladesh reveals that reduced fecal intestinal alkaline phosphatase levels are independently associated with gestational diabetes mellitus, suggesting a potential role for gut-derived metabolic dysregulation in the condition despite the marker's current limitation as a standalone diagnostic tool.
The StartRight prospective observational study demonstrates that a classification model combining routine clinical features, such as lower age and BMI, unintentional weight loss, and high presentation glycaemia, with or without islet autoantibodies, achieves high accuracy in differentiating adult-onset type 1 from type 2 diabetes at diagnosis, outperforming current clinical guidance.
This large-scale observational study reveals that semaglutide treatment is associated with a sustained, dose-dependent reduction in the risk of various neuropsychiatric disorders that operates independently of weight loss, suggesting a direct beneficial effect via central nervous system GLP-1 receptor engagement.
Based on an analysis of NHANES 2015-2018 data, current smoking is significantly associated with higher HbA1c levels in U.S. adults without diabetes, whereas former smoking shows no such association, suggesting the effect diminishes after cessation.