🩺 Category

endocrinology

40 papers

Endocrinology explores the complex network of hormones that regulate nearly every function in the human body, from metabolism and growth to mood and reproduction. When this delicate chemical signaling system falters, it can lead to a wide range of conditions, including diabetes, thyroid disorders, and fertility issues. Understanding these mechanisms is vital for developing treatments that restore balance and improve quality of life.

At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category as it becomes available, transforming dense medical findings into clear, plain-language overviews alongside detailed technical summaries. This approach ensures that both curious readers and specialists can stay informed without getting lost in jargon.

Below are the latest endocrinology preprints we have processed, offering fresh insights into how our internal chemistry shapes health and disease.

🩺 endocrinology

Longitudinal insights into dynamic patterns and cumulative burdens of biological age acceleration in relation to type II diabetes mellitus, all-cause mortality and glycemic traits

This longitudinal study of UK Biobank participants demonstrates that dynamic transitions to accelerated biological aging and cumulative aging burdens are independently associated with increased risks of type II diabetes and all-cause mortality, partly mediated by glycemic dysregulation, thereby highlighting biological aging as a promising intervention target.

Yan, Y., Zheng, C., zeng, p.2026-04-07
🩺 endocrinology

A Manual of Procedures for the Generation of the AI-Ready and Exploratory Atlas for Diabetes Insights (AI-READI) Database.

This paper details the standardized procedures and protocols for the NIH Bridge2AI AI-READI project, which aims to generate a high-quality, multimodal dataset to advance artificial intelligence research in type 2 diabetes mellitus.

Matthies, D. S., Edberg, J. C., Baxter, S. L., Lee, A. Y., Lee, C. S., McGwin, G., Owen, J. P., Zangwill, L. M., Owsley (…)2026-04-04
🩺 endocrinology

Efficacy and Safety of Oral L-Ergothioneine Supplementation in Improving Ovarian Reserve: A Single-Center, Open-Label, Self-Controlled Clinical Trial

This single-center, open-label, self-controlled clinical trial demonstrates that oral L-ergothioneine supplementation (120 mg/day for three cycles) safely and significantly improves ovarian reserve markers (AMH, FSH, E2) and alleviates menstrual, sleep, and quality-of-life symptoms in women with diminished ovarian reserve, providing the first clinical evidence of its systemic benefits in reproductive aging.

Liu, W., Guo, C., Ding, W., Cao, J., Ju, H., Liu, F., Xiao, G.2026-04-04
🩺 endocrinology

Evaluating the Use of GLP-1 Receptor Agonists in Wolfram syndrome Patients

This retrospective cohort study of 84 Wolfram syndrome patients found that while GLP-1 receptor agonists are frequently used, they did not significantly improve glycemic control or halt visual decline and were often discontinued due to gastrointestinal side effects, highlighting the need for prospective trials to evaluate their potential as a disease-modifying therapy.

Lee, L., Tang, A. F., Asako, A., Ning, S. F., Reed, H. A., Duncan, E., Lugar, H. M., Hoekel, J., Marshall, B. A., Hershe (…)2026-04-02
🩺 endocrinology

An ancestry-enriched PIEZO1 missense variant biases HbA1c-based diagnosis of prediabetes and type 2 diabetes in South Asians

An ancestry-enriched PIEZO1 missense variant common in South Asians lowers HbA1c levels independent of blood glucose, leading to the systematic underestimation of prediabetes and type 2 diabetes risk and a higher likelihood of missed diagnoses and complications when relying solely on HbA1c for screening.

Samuel, M., Stow, D., Bui, V., Bigossi, M., Hodgson, S., Martin, S., Soenksen, J., Armirola-Ricaurte, C., Rison, S., Cas (…)2026-03-30
🩺 endocrinology

Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness

This retrospective study of over 103 million women using TriNetX data reveals that pain affects approximately 20.67% of women with PCOS, with significant racial disparities in prevalence and associated health risks, while also demonstrating that PCOS-related medications effectively reduce pain diagnoses.

Cherlin, T., Mohammed, S., Strydesky, S., Ottey, S., Sherif, K., Setia Verma, S.2026-03-27
🩺 endocrinology

HbA1c-based diagnosis of type 2 diabetes and complication risk are distorted in British south Asians due to HbE thalassaemia trait

This study reveals that the HbE thalassaemia trait, which is prevalent but often undiagnosed among British South Asians, artificially elevates HbA1c levels without increasing blood glucose, leading to the overdiagnosis and overtreatment of type 2 diabetes and a distorted assessment of complication risks.

Hodgson, S., L'Esperance, V., Samuel, M., Siddiqui, M., Stow, D., Armirola-Ricaurte, C., Genes & Health Research Team, (…)2026-03-27
🩺 endocrinology

Oxytocin and its role in caloric intake and appetite: A preregistered living systematic review and meta-analysis

This preregistered living systematic review and meta-analysis provides evidence that exogenous oxytocin reduces appetite and caloric intake in specific patient groups, such as those with obesity or type II diabetes, but finds no statistically significant effects in healthy individuals, suggesting the need for further research to draw definitive conclusions.

Sartorius, A. I., Deilhaug, E., Kang, H., Dufour, D., Walle, K. M., Eddy, K. T., van der Meer, D., Westlye, L. T., Andre (…)2026-03-26
🩺 endocrinology

Prevalence, treatment rates and control of dyslipidemia among diabetes patients in northern Nigeria: A cross-sectional, multicenter study

This multicenter cross-sectional study in northern Nigeria reveals that dyslipidemia affects nearly 60% of diabetes patients, is independently associated with female gender and proteinuria, and remains poorly managed with only 17.1% of patients achieving cardiovascular risk targets due to limited treatment options and low guideline adherence.

Alkali, N. H., Uloko, A. E., Osaigbovo, G. O., Bakari, A. G., Bello, M. R., Garba, M. A., Fika, G. M., Muhammad, A. S. (…)2026-03-23