🩺 Category

endocrinology

47 papers

Longitudinal insights into dynamic patterns and cumulative burdens of biological age acceleration in relation to type II diabetes mellitus, all-cause mortality and glycemic traits

This longitudinal study of UK Biobank participants demonstrates that dynamic transitions to accelerated biological aging and cumulative aging burdens are independently associated with increased risks of type II diabetes and all-cause mortality, partly mediated by glycemic dysregulation, thereby highlighting biological aging as a promising intervention target.

Yan, Y., Zheng, C., zeng, p.2026-04-07🩺 endocrinology

Semaglutide cardiovascular outcomes align more closely with attained dose than achieved weight loss

Based on a large-scale analysis of electronic health records, this study demonstrates that semaglutide's long-term cardiovascular benefits are more strongly driven by the maximum therapeutic dose attained than by the magnitude of weight loss achieved, suggesting direct heart-specific mechanisms beyond weight reduction.

Murugadoss, K., Venkatakrishnan, A., Gregg, C. + 1 more2026-04-06🩺 endocrinology

Temporally Phenotyping GLP-1RA Case Reports with Large Language Models: A Textual Time Series Corpus and Risk Modeling

This paper introduces a textual time-series corpus of 136 GLP-1RA case reports and demonstrates that large language models can effectively extract and sequence clinical events from unstructured text, enabling downstream risk modeling that identified a significantly lower risk of respiratory sequelae among GLP-1 users compared to non-users.

Kumar, S., Weiss, J.2026-04-06🩺 endocrinology

Prediabetes is associated with early-emerging and persistent cognitive differences in youth with overweight and obesity

This two-year longitudinal study demonstrates that youth with overweight or obesity who have prediabetes exhibit early-emerging, persistent, and adiposity-independent deficits in IQ, executive function, and processing speed, suggesting that neurocognitive impairment is a feature of metabolic risk that precedes the onset of overt type 2 diabetes.

Quillian, J., Morys, F., Attuquayefio, T. + 12 more2026-04-04🩺 endocrinology

Efficacy and Safety of Oral L-Ergothioneine Supplementation in Improving Ovarian Reserve: A Single-Center, Open-Label, Self-Controlled Clinical Trial

This single-center, open-label, self-controlled clinical trial demonstrates that oral L-ergothioneine supplementation (120 mg/day for three cycles) safely and significantly improves ovarian reserve markers (AMH, FSH, E2) and alleviates menstrual, sleep, and quality-of-life symptoms in women with diminished ovarian reserve, providing the first clinical evidence of its systemic benefits in reproductive aging.

Liu, W., Guo, C., Ding, W. + 4 more2026-04-04🩺 endocrinology

The Effects of Gender Affirming Hormone Treatment on Transgender Mens Musculoskeletal Health: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis concludes that while masculinizing gender-affirming hormone treatment reliably increases lean mass and muscle strength in transgender men without significantly altering bone mineral density at key sites, the current evidence base remains methodologically weak and highly variable, underscoring the need for continued clinical monitoring and higher-quality longitudinal research.

Hu, K., Brown, A., Montagner-Moraes, S. + 4 more2026-04-02🩺 endocrinology

Evaluating the Use of GLP-1 Receptor Agonists in Wolfram syndrome Patients

This retrospective cohort study of 84 Wolfram syndrome patients found that while GLP-1 receptor agonists are frequently used, they did not significantly improve glycemic control or halt visual decline and were often discontinued due to gastrointestinal side effects, highlighting the need for prospective trials to evaluate their potential as a disease-modifying therapy.

Lee, L., Tang, A. F., Asako, A. + 8 more2026-04-02🩺 endocrinology

CGM accuracy and reliability compared to point of care testing in older inpatients with comorbid type 2 diabetes and cognitive impairment

This study demonstrates that continuous glucose monitoring (CGM) is a safe, clinically accurate, and viable alternative to point-of-care testing for managing blood glucose in older hospitalized patients with type 2 diabetes and cognitive impairment, offering comparable metrics while better capturing nocturnal hypoglycemia.

Donat-Ergin, B., Mattishent, K., Minihane, A. M. + 4 more2026-03-31🩺 endocrinology

Longitudinal Variability of Lipoprotein(a) in Children with Type 1 Diabetes: Implications for Cardiovascular Risk Stratification

This study reveals that Lipoprotein(a) levels in children with type 1 diabetes exhibit significant longitudinal variability and seasonal fluctuations, challenging the assumption of stability and suggesting that single measurements may misclassify cardiovascular risk, thereby supporting the need for repeated assessments during adolescence.

Iafrate-Luterbacher, F., Jimenez-Sanchez, C., Anastasiadou, M. L. + 5 more2026-03-30🩺 endocrinology

HbA1c-based diagnosis of type 2 diabetes and complication risk are distorted in British south Asians due to HbE thalassaemia trait

This study reveals that the HbE thalassaemia trait, which is prevalent but often undiagnosed among British South Asians, artificially elevates HbA1c levels without increasing blood glucose, leading to the overdiagnosis and overtreatment of type 2 diabetes and a distorted assessment of complication risks.

Hodgson, S., L'Esperance, V., Samuel, M. + 10 more2026-03-27🩺 endocrinology

Dynamic changes in compressive and shear plantar tissue properties during gait and rest in people living with and without diabetes

This pilot study utilized a novel PlantarSense tool to demonstrate that people with diabetes exhibit impaired plantar tissue thermoregulation and reduced recovery of shear and compressive energy dissipation ratios after walking compared to non-diabetic controls, highlighting dynamic tissue adaptations relevant to diabetic foot ulceration risk.

Lin, C., Haron, A., Crosby, D. + 7 more2026-03-26🩺 endocrinology

HNF1B-MODY in the Norwegian MODY Registry and the Norwegian Childhood Diabetes Registry: Clinical insights and prevalence informed by genetic and functional evaluation

This study integrates genetic, functional, and clinical data from Norwegian diabetes registries to characterize the prevalence and features of HNF1B-MODY and 17q12 deletions, demonstrating that impaired transactivation correlates with clinical severity and supporting expanded screening for HNF1B alterations in children with renal anomalies regardless of diabetes status.

Pavithram, A., Johansson, B. B., Tjora, E. + 14 more2026-03-26🩺 endocrinology

Oxytocin and its role in caloric intake and appetite: A preregistered living systematic review and meta-analysis

This preregistered living systematic review and meta-analysis provides evidence that exogenous oxytocin reduces appetite and caloric intake in specific patient groups, such as those with obesity or type II diabetes, but finds no statistically significant effects in healthy individuals, suggesting the need for further research to draw definitive conclusions.

Sartorius, A. I., Deilhaug, E., Kang, H. + 8 more2026-03-26🩺 endocrinology

Subgroups of adult-onset diabetes: a prospective follow-up study of progression of insulin resistance and deficiency and association with liver steatosis and fibrosis

This prospective study demonstrates that while diabetes subgroups based on insulin deficiency or resistance become less distinct over time, liver fibrosis remains strongly associated with insulin resistance independent of BMI, suggesting that subgroup classification is most effective near diagnosis and that insulin resistance, rather than just obesity, is a key driver of liver disease risk.

Laitinen, A. T. J., Karajamaki, A., Karajamaki, A. + 8 more2026-03-25🩺 endocrinology

The effect of lifestyle interventions using behavior change techniques to improve physical activity, sedentary behavior and/or sleep in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis of 66 randomized controlled trials involving over 18,000 adults with type 2 diabetes demonstrates that lifestyle interventions utilizing behavior change techniques, particularly goal setting, self-monitoring, feedback, and social support, effectively increase physical activity, reduce sedentary time, and improve sleep quality, though sleep duration remains an underexplored outcome.

De Craemer, M., Kinaupenne, M., Decraene, M. + 2 more2026-03-25🩺 endocrinology