30 papers
Endocrinology explores the complex network of hormones that regulate nearly every function in the human body, from metabolism and growth to mood and reproduction. When this delicate chemical signaling system falters, it can lead to a wide range of conditions, including diabetes, thyroid disorders, and fertility issues. Understanding these mechanisms is vital for developing treatments that restore balance and improve quality of life.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category as it becomes available, transforming dense medical findings into clear, plain-language overviews alongside detailed technical summaries. This approach ensures that both curious readers and specialists can stay informed without getting lost in jargon.
Below are the latest endocrinology preprints we have processed, offering fresh insights into how our internal chemistry shapes health and disease.
This cross-sectional study of 508 participants reveals that circulating CtBP2 levels exhibit weak but statistically significant positive associations with measures of adiposity, particularly abdominal fat, but show no significant correlation with lipid profile abnormalities.
This hospital-based multicentre cross-sectional study in Bangladesh reveals that reduced fecal intestinal alkaline phosphatase levels are independently associated with gestational diabetes mellitus, suggesting a potential role for gut-derived metabolic dysregulation in the condition despite the marker's current limitation as a standalone diagnostic tool.
The StartRight prospective observational study demonstrates that a classification model combining routine clinical features, such as lower age and BMI, unintentional weight loss, and high presentation glycaemia, with or without islet autoantibodies, achieves high accuracy in differentiating adult-onset type 1 from type 2 diabetes at diagnosis, outperforming current clinical guidance.
This large-scale observational study reveals that semaglutide treatment is associated with a sustained, dose-dependent reduction in the risk of various neuropsychiatric disorders that operates independently of weight loss, suggesting a direct beneficial effect via central nervous system GLP-1 receptor engagement.
Based on an analysis of NHANES 2015-2018 data, current smoking is significantly associated with higher HbA1c levels in U.S. adults without diabetes, whereas former smoking shows no such association, suggesting the effect diminishes after cessation.
This longitudinal study of UK Biobank participants demonstrates that dynamic transitions to accelerated biological aging and cumulative aging burdens are independently associated with increased risks of type II diabetes and all-cause mortality, partly mediated by glycemic dysregulation, thereby highlighting biological aging as a promising intervention target.
This paper details the standardized procedures and protocols for the NIH Bridge2AI AI-READI project, which aims to generate a high-quality, multimodal dataset to advance artificial intelligence research in type 2 diabetes mellitus.
This single-center, open-label, self-controlled clinical trial demonstrates that oral L-ergothioneine supplementation (120 mg/day for three cycles) safely and significantly improves ovarian reserve markers (AMH, FSH, E2) and alleviates menstrual, sleep, and quality-of-life symptoms in women with diminished ovarian reserve, providing the first clinical evidence of its systemic benefits in reproductive aging.
This retrospective cohort study of 84 Wolfram syndrome patients found that while GLP-1 receptor agonists are frequently used, they did not significantly improve glycemic control or halt visual decline and were often discontinued due to gastrointestinal side effects, highlighting the need for prospective trials to evaluate their potential as a disease-modifying therapy.
An ancestry-enriched PIEZO1 missense variant common in South Asians lowers HbA1c levels independent of blood glucose, leading to the systematic underestimation of prediabetes and type 2 diabetes risk and a higher likelihood of missed diagnoses and complications when relying solely on HbA1c for screening.