🩺 Category

endocrinology

47 papers

Endocrinology explores the complex network of hormones that regulate nearly every function in the human body, from metabolism and growth to mood and reproduction. When this delicate chemical signaling system falters, it can lead to a wide range of conditions, including diabetes, thyroid disorders, and fertility issues. Understanding these mechanisms is vital for developing treatments that restore balance and improve quality of life.

At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category as it becomes available, transforming dense medical findings into clear, plain-language overviews alongside detailed technical summaries. This approach ensures that both curious readers and specialists can stay informed without getting lost in jargon.

Below are the latest endocrinology preprints we have processed, offering fresh insights into how our internal chemistry shapes health and disease.

🩺 endocrinology

Weight Loss With Microdose Tirzepatide: Real-World Outcomes in Patients Initiating Treatment Below 2.5 mg Weekly

This retrospective observational study suggests that adults initiating compounded injectable tirzepatide at microdoses of 1–2 mg/week experience progressive weight loss over time, with mean reductions ranging from 2.18% to 6.10% across 14- to 89-day observation windows, though the findings remain hypothesis-generating due to the uncontrolled design and sparse long-term follow-up.

Hastings, J., Lee, J.2026-09-17
🩺 endocrinology

Noninvasive Wound Swab Proteomics Enables Prognostic Stratification of Diabetic Foot Ulcer Healing: The HEAL-DFU Proof-of-Concept Study

The HEAL-DFU study demonstrates that a noninvasive wound swab proteomics approach can identify a 27-protein signature linked to innate immunity and dyslipidemia, enabling the creation of a prognostic score that significantly outperforms clinical variables in predicting diabetic foot ulcer healing trajectories.

Clos-Garcia, M., Jain, S. Y., Naaman, C. H., Raguz, J. A., Schaefer, Z., Kaur, G., Curovic, V. R., Kirketerp-Moller, K. (…)2026-09-16
🩺 endocrinology

Assessing Type 2 Diabetes and GLP-1 agonist response trajectories with a proteogenomic atlas of disease progression

By integrating proteogenomic data from 42,000 UK Biobank participants with Mendelian randomization and semaglutide trial results, this study maps the distinct causal trajectories of adiposity, insulin resistance, and glycemia in Type 2 diabetes progression and identifies persistent protein dysregulations that drive residual cardiovascular risk despite GLP-1 agonist treatment.

Tangirala, S., Isaac, S., Gehad, Y., Roquefort, F., Gabrieli, P., Miller, G., Thaker, V. V., Tierney, B. T., Patel, C. J (…)2026-08-31
🩺 endocrinology

Prevalence of excess adiposity and clinical obesity in a Mexican nationally representative survey

A nationally representative study of Mexican adults reveals that relying solely on Body Mass Index (BMI) underestimates clinically relevant obesity, as nearly a quarter of individuals with clinical obesity have a BMI below 30 kg/m², highlighting the need to incorporate waist-based measurements for more accurate identification of excess adiposity and metabolic risk.

Torres-Chavez, M. C., Antonio-Villa, N. E., Gonzalez-Arias, M., Araiza-Garaygordobil, D., Martinez-Amezcua, P.2026-08-21
🩺 endocrinology

Acceptability, Feasibility, and User Experiences of Continuous Glucose Monitoring in Type 1 Diabetes in Kenya: Perspectives of Adolescents, Young Adults, Caregivers, and Healthcare Providers

This study demonstrates that Continuous Glucose Monitoring is highly acceptable and beneficial for adolescents, young adults, caregivers, and healthcare providers in Kenya by improving engagement and reducing monitoring burdens, though its broader implementation is currently hindered by significant cost and availability barriers.

Karume, A. K., Amolo, P., Mungai, L., Moraa, H., Arunga, T., Nzove, E., Ndambuki, C., Muhwava, L., Kamau, Y., Marban-Cas (…)2026-08-18
🩺 endocrinology

Spatial transcriptomics maps distinct signatures of human intermuscular adipose expansion in mice

This study integrates human bulk transcriptomics with mouse spatial transcriptomics to define distinct stromal niches driving intermuscular adipose expansion in metabolic disease, revealing that EBF2-mediated lineage plasticity, rather than progenitor abundance, orchestrates this spatially organized remodeling.

Pathak, E., Tom, R. Z., Kim, M., Sachs, S., Zhang, Y., Walter, M., Pfluger, P. T., Feuchtinger, A., Dyar, K. A., Bergman (…)2026-06-26
🩺 endocrinology

Predicting county-level diagnosed diabetes prevalence in the United States using explainable gradient boosting and geographic interpretation

This study utilizes an explainable LightGBM framework integrated with diverse public data sources to accurately predict and geographically interpret county-level diagnosed diabetes prevalence across the United States, identifying poverty and food insecurity as dominant structural drivers while emphasizing that the resulting insights serve as model-based explanations rather than causal effects.

Yahaya, Y., Khan, S., Rani Saha, P., Meia, M. A. A.2026-06-26