🩺 Category

endocrinology

30 papers

Endocrinology explores the complex network of hormones that regulate nearly every function in the human body, from metabolism and growth to mood and reproduction. When this delicate chemical signaling system falters, it can lead to a wide range of conditions, including diabetes, thyroid disorders, and fertility issues. Understanding these mechanisms is vital for developing treatments that restore balance and improve quality of life.

At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category as it becomes available, transforming dense medical findings into clear, plain-language overviews alongside detailed technical summaries. This approach ensures that both curious readers and specialists can stay informed without getting lost in jargon.

Below are the latest endocrinology preprints we have processed, offering fresh insights into how our internal chemistry shapes health and disease.

Data Driven Endocrine Metabolic Phenotypes in Young Women With Polycystic Ovary Syndrome and Associations With Cardiometabolic Risk Markers

In a large cohort of young women with polycystic ovary syndrome, data-driven clustering identified two distinct endocrine-metabolic phenotypes, including a rare thyroid/autoimmune-enriched subgroup associated with a higher prevalence of atherogenic lipid profiles, highlighting the value of integrated profiling for early cardiometabolic risk stratification beyond traditional diagnostic criteria.

Piorkowska, N. J., Nicifur, K., Lesniewski, M., Franik, G., Bizon, A.2026-03-03🩺 endocrinology

Reliability and Structure of Diabetes Diet Adherence Scale (D-DAS): A Follow-up Study among Type 2 Diabetes Patients of India

This study validates the reliability and structure of the Diabetes Diet Adherence Scale (D-DAS) for Indian type 2 diabetes patients, finding it to be a robust measurement tool while revealing that only 68.3% of participants adhered to their prescribed diet plans.

Kushwaha, S., Srivastava, R., Bhadada, S. K., Thakur, J. S., Sagar, V., Tharu, R., Khanna, P.2026-03-02🩺 endocrinology

scRNAseq of thyroid eye disease orbital fat demonstrates fibroblast thyroid hormone signaling and SPARC production

This study identifies SPARC as a promising biomarker for active thyroid eye disease by demonstrating its elevated expression in orbital fibroblasts, its correlation with disease severity and thyroid hormone levels, and its decline following the active phase of the condition.

Robinson, E. J., Boest-Bjerg, K., Cuadros Sanchez, C., Agnello, S., Delimichalis, A., Göertz, G.-E., Nolte, I., Pearson, J. A., Andrews, R., Muller, I., Smith, E., Palmer, L., Furmaniak, J., Ludgate (…)2026-03-02🩺 endocrinology

Engagement With a Breath-Based Metabolic Device Is Associated with Greater Weight Loss in Self-Reported Real-World GLP-1RA Users

In a retrospective analysis of 2,296 real-world GLP-1 receptor agonist users, higher engagement with a breath-based metabolic monitoring device was significantly associated with greater 24-week weight loss and improved metabolic flexibility, though the observational nature of the study precludes definitive causal conclusions.

Ben David, G., Udasin, R., Golan, D., Mor, M., Mor, M.2026-02-24🩺 endocrinology

Accounting for age-related increases in HbA1c more accurately quantifies risk of Type 1 Diabetes progression in islet autoantibody-positive adults

This study demonstrates that accounting for age-related increases in HbA1c through age-adjusted values or a higher threshold (≥6.0%) in adults ≥30 years more accurately quantifies Type 1 Diabetes progression risk in islet autoantibody-positive individuals, thereby preventing the overestimation of risk that occurs with standard dysglycemia criteria.

Templeman, E. L., Thomas, N., Martin, S., Wherrett, D. K., Redondo, M. J., Sherr, J., Petrelli, A., Jacobsen, L., Salami, F., Lonier, J., Evans-Molina, C., Sosenko, J., Barroso, I., Oram, R. A., Sims (…)2026-02-19🩺 endocrinology

Policy Gaps in Type 1 Diabetes: A UK Audit of National Governing Bodies

This UK audit reveals that despite the critical role of National Governing Bodies in ensuring safe sports participation, only a small minority (2%) have dedicated policies to support athletes with Type 1 Diabetes, with similarly scarce provisions for those with asthma, epilepsy, and allergies, highlighting an urgent need for comprehensive national policy development.

Abdel-Magid, M., Cockcroft, E., Bright, C., Mann, R., Andrews, R. C.2026-02-18🩺 endocrinology

Androgen-Related Associations With CBC-Derived Inflammatory Indices in Young Women With Polycystic Ovary Syndrome

In a cross-sectional study of 1,300 young women with polycystic ovary syndrome, androgen-related biomarkers were found to be independently associated with specific complete blood count-derived inflammatory indices, particularly red cell distribution width and platelet-to-lymphocyte ratio, even after accounting for insulin resistance.

Piorkowska, N. J., Bizon, A., Bizon, K., Franik, G.2026-02-16🩺 endocrinology

Longitudinal Proteogenomic Analysis Reveals Mechanistic Insights into the Progression from Prediabetes to Type 2 Diabetes

This longitudinal proteogenomic study of 458 participants elucidates the molecular mechanisms driving the progression from prediabetes to type 2 diabetes by identifying predictive plasma proteins, mapping genetic variants, and establishing causal links between allele-driven protein expression and key metabolic traits, thereby supporting the view that these conditions represent stages on a unified metabolic spectrum.

Singh, A., Ganslmeier, M., Tutino, M., Park, Y.-C., Machann, J., Schick, F., Peter, A., Lehmann, R., Wang, Y., Cheng, Y., Sandforth, L., Schuth, S., Seissler, J., Perakakis, N., Schwarz, P. E. H., Sze (…)2026-02-16🩺 endocrinology