endocrinology papers | Gist.Science

Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Diabetes Mellitus

This large-scale, multi-national real-world study found that individual glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors exhibit broadly comparable cardiovascular effectiveness in patients with type 2 diabetes, supporting current treatment guidelines that prioritize individual patient factors over specific drug selection.

Bu, F., Wu, R., Ostropolets, A. + 18 more2026-02-24🩺 endocrinology

Elevated FGF21 and triglycerides in SLC25A13 carriers support the G3P-ChREBP Citrin Deficiency disease hypothesis

This study validates the G3P-ChREBP hypothesis for Citrin Deficiency by demonstrating that human carriers of SLC25A13 mutations exhibit elevated circulating FGF21 and a unique positive correlation between FGF21 and triglycerides, mirroring the metabolic dysfunction observed in mouse models.

Brenner, C., Tiwari, V., Chen, Y.-M. + 1 more2026-02-19🩺 endocrinology

Accounting for age-related increases in HbA1c more accurately quantifies risk of Type 1 Diabetes progression in islet autoantibody-positive adults

This study demonstrates that accounting for age-related increases in HbA1c through age-adjusted values or a higher threshold (≥6.0%) in adults ≥30 years more accurately quantifies Type 1 Diabetes progression risk in islet autoantibody-positive individuals, thereby preventing the overestimation of risk that occurs with standard dysglycemia criteria.

Templeman, E. L., Thomas, N., Martin, S. + 13 more2026-02-19🩺 endocrinology

Policy Gaps in Type 1 Diabetes: A UK Audit of National Governing Bodies

This UK audit reveals that despite the critical role of National Governing Bodies in ensuring safe sports participation, only a small minority (2%) have dedicated policies to support athletes with Type 1 Diabetes, with similarly scarce provisions for those with asthma, epilepsy, and allergies, highlighting an urgent need for comprehensive national policy development.

Abdel-Magid, M., Cockcroft, E., Bright, C. + 2 more2026-02-18🩺 endocrinology

Smartphone-based App to Assess Diabetic Peripheral Neuropathy

This study demonstrates that a novel smartphone-based application can accurately assess diabetic peripheral neuropathy by measuring vibration perception thresholds, showing significant correlations with standard tuning fork exams and clinical markers to enable early, accessible detection of nerve damage.

Adenekan, R. A. G., Adenekan, A. E., Leung, K. K. + 9 more2026-02-16🩺 endocrinology

Androgen-Related Associations With CBC-Derived Inflammatory Indices in Young Women With Polycystic Ovary Syndrome

In a cross-sectional study of 1,300 young women with polycystic ovary syndrome, androgen-related biomarkers were found to be independently associated with specific complete blood count-derived inflammatory indices, particularly red cell distribution width and platelet-to-lymphocyte ratio, even after accounting for insulin resistance.

Piorkowska, N. J., Bizon, A., Bizon, K. + 1 more2026-02-16🩺 endocrinology

Longitudinal Proteogenomic Analysis Reveals Mechanistic Insights into the Progression from Prediabetes to Type 2 Diabetes

This longitudinal proteogenomic study of 458 participants elucidates the molecular mechanisms driving the progression from prediabetes to type 2 diabetes by identifying predictive plasma proteins, mapping genetic variants, and establishing causal links between allele-driven protein expression and key metabolic traits, thereby supporting the view that these conditions represent stages on a unified metabolic spectrum.

Singh, A., Ganslmeier, M., Tutino, M. + 29 more2026-02-16🩺 endocrinology

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