24 papers
This systematic review and meta-analysis demonstrates that deep brain stimulation targeting the ventral intermediate nucleus of the thalamus consistently produces substantial tremor reduction across diverse targeting methodologies, despite significant heterogeneity in surgical approaches and study designs.
This study reveals significant variation in tolvaptan prescribing across UK kidney centers, where a substantial proportion of eligible patients with ADPKD remain untreated while many ineligible patients receive the therapy, leading to substantial potential losses in both healthcare costs and quality-adjusted life years.
This study proposes and validates a novel hybrid XGBoost-LSTM framework with temporal attention (XLA) that significantly outperforms traditional static models in predicting chronic kidney disease progression by leveraging longitudinal claims data to capture temporal disease trajectories, while also highlighting the critical limitation of cross-sectional features in the absence of direct UACR measurements.
This study identifies urinary myoglobin as a specific noninvasive biomarker for distinguishing CUBN-related chronic benign proteinuria (PROCHOB) from glomerular diseases, offering a diagnostic strategy that reduces unnecessary kidney biopsies and guides targeted genetic testing.
This proof-of-concept study demonstrates that nanoscale podocyte morphometric parameters, quantified via AI-assisted high-resolution microscopy, exhibit greater sensitivity than conventional electron microscopy in predicting disease progression and treatment response in IgA Nephropathy, suggesting their potential to improve risk stratification pending validation in larger cohorts.
This study utilizes an XGBoost machine learning model to identify soil type, water pH, electrical conductivity, and fluoride concentration as key environmental predictors of Chronic Kidney Disease of unknown etiology (CKDu) in Sri Lanka, thereby highlighting the need for targeted water quality and agrochemical interventions to mitigate the disease's prevalence.
In a retrospective cohort study of 503 patients with biopsy-proven kidney disease, lower urine pH was found to be independently associated with adverse kidney outcomes and increased medullary cast formation, suggesting its potential role as a prognostic marker and contributor to tubular obstruction.
This study identifies a specific Anillin (ANLN) variant (I1109V) prevalent in patients with non-diabetic proteinuric kidney disease that drives tubular epithelial cell death, junctional instability, and barrier dysfunction through disrupted actin dynamics and enhanced inflammatory signaling.
This Japanese cohort study of patients with chronic kidney disease or heart failure found that while physical quality of life was generally impaired, the use of potassium binders had a less negative impact on quality of life than dietary restrictions and supported the continued use of RAAS inhibitors.
This study demonstrates that chronic kidney disease significantly amplifies the risk of gabapentin-associated dementia due to impaired renal clearance, a finding supported by large-scale cohort analyses and adverse event reporting that underscores the need to integrate renal function into gabapentinoid prescribing decisions.
In a large randomized trial, an educational intervention consisting of a booklet and video failed to increase kidney transplant evaluation completion or living donor transplant receipt, with further analysis suggesting that experiences of healthcare-related discrimination significantly diminished the intervention's effectiveness.
This study demonstrates that medullary cast formation is an independent predictor of adverse kidney outcomes in chronic kidney disease patients and provides incremental prognostic value beyond conventional cortical pathology assessments.
This cross-sectional survey study demonstrates that the availability of the Kidney-CAP bleeding cessation device positively influences clinical decision-making by increasing patients' desire for arteriovenous fistula creation and kidney transplantation, while prompting healthcare providers to recommend home hemodialysis more frequently.
This qualitative study involving transplant patients, coordinators, and providers at the University of New Mexico reveals that a personalized kidney risk prediction tool must prioritize plain language explanations, contextual education, and workflow-aligned design to effectively support decision-making and potentially reduce organ discard rates.
This study utilizes single-nucleus transcriptomics of over 150 kidney biopsies to identify shared multicellular injury programs in acute and chronic kidney disease that transcend traditional clinical categories, revealing non-invasive protein signatures predictive of long-term renal outcomes.
This study of 350 Ethiopian children found poor agreement between cystatin C- and creatinine-based estimated glomerular filtration rates, revealing that creatinine-based equations significantly overestimate kidney function compared to cystatin C-based estimates, thus highlighting the need for local validation using gold-standard clearance methods.
This cross-sectional study of hip fracture patients found that while most exhibited low bone turnover, circulating biomarkers BAP, TRAP5b, and sclerostin were significantly associated with static histomorphometry parameters of bone formation and resorption, suggesting their potential utility as adjuncts to PTH for assessing bone turnover and guiding therapy in patients with and without chronic kidney disease.
This large-scale genome-wide association study of creatinine clearance in nearly 59,000 individuals identifies 16 genetic loci influencing kidney function, including two novel variants found in both sexes and two female-specific loci, thereby highlighting the advantages of using muscle-mass-independent measures to uncover sex-specific genetic architectures in chronic kidney disease.
This nested case-control study identifies that elevated serum total immunoglobulin E (IgE) levels precede the early loss of kidney function in individuals at risk of Mesoamerican Nephropathy, suggesting that IgE-mediated pathways, potentially driven by infections or allergies rather than heat exposure, may play a central role in the disease's etiology.
The Kidney Precision Medicine Project demonstrates that integrating kidney biopsy data with clinical and molecular analyses can redefine chronic kidney disease by revealing diverse underlying etiologies, distinct pathological and transcriptional signatures, and improved prognostic models that may alter therapeutic decisions.