24 papers
The KD Atlas is a comprehensive, user-friendly online resource that integrates data from over 25 large-scale multi-omics studies to construct a network of more than 1.2 million relationships between genes, proteins, metabolites, and kidney disease phenotypes, enabling researchers to explore molecular mechanisms and prioritize therapeutic targets without specialized bioinformatics expertise.
In a multicenter cohort study of patients undergoing coronary angiography, chronic use of SGLT2 inhibitors was identified as an independent protective factor against post-contrast acute kidney injury, significantly reducing the risk even after adjusting for other clinical variables.
This study of a large Japanese IgA nephropathy cohort demonstrates that a steeper decline in estimated glomerular filtration rate (eGFR) slope is significantly associated with an increased risk of adverse kidney outcomes, supporting its validity as a reliable surrogate endpoint for clinical trials and risk stratification beyond current eGFR levels.
A large French survey of patients with autosomal dominant polycystic kidney disease reveals that diagnostic disclosure frequently occurs outside nephrology care, often by radiologists, and is associated with poor tact and inadequate information, leading to significant psychological distress and negative patient experiences.