Serum Total Immunoglobulin-E Levels and Early Loss of eGFR in Individuals at Risk of Mesoamerican Nephropathy: A Nested Case-Control Analysis from a Population Representative Follow-Up Study
This nested case-control study identifies that elevated serum total immunoglobulin E (IgE) levels precede the early loss of kidney function in individuals at risk of Mesoamerican Nephropathy, suggesting that IgE-mediated pathways, potentially driven by infections or allergies rather than heat exposure, may play a central role in the disease's etiology.