ophthalmology papers | Gist.Science

Three-dimensional topography of Descemet's membrane in Fuchs endothelial corneal dystrophy using laser scanning confocal microscopy and white-light interferometry

This study demonstrates that combining white-light interferometry and laser scanning confocal microscopy enables label-free, high-resolution three-dimensional topographic characterization of Descemet's membrane in Fuchs endothelial corneal dystrophy, revealing significantly increased surface roughness and distinct spatial zones of guttae compared to healthy controls.

Maurin, C., Poinard, S., Travers, G. + 7 more2026-04-08👁️ ophthalmology

Impact of Socioeconomic Status on Clinical Features and Outcomes of Bacterial Keratitis: The Midlands Infectious Keratitis Study

This retrospective multicentre study of 320 patients in the UK found that socioeconomic deprivation does not significantly influence the clinical presentation or outcomes of bacterial keratitis, suggesting that universal access to emergency ophthalmic care may attenuate potential disparities in this sight-threatening condition.

Javed, K. M. A. A., Ozturk, B., Anwar, S. + 6 more2026-04-07👁️ ophthalmology

How accurate are our near reading charts? An assessment of 19 charts against ISO standards.

This study evaluated 19 commercially available near reading charts against ISO standards and found that none fully met all requirements due to significant variability in text size and surface finish, prompting the development of a new compliant chart to ensure accurate near vision assessment.

Murphy, T. I., Chen, J., Leung, M.2026-04-04👁️ ophthalmology

One-year efficacy and tolerability of 0.05% atropine for myopia control in Estonia: a prospective cohort study

This prospective cohort study demonstrates that 0.05% atropine is an effective and well-tolerated treatment for myopia control in patients with light irises, with early axial length changes serving as a predictive marker for long-term treatment response.

Linntam, D., Palumaa, K., Palumaa, T.2026-04-04👁️ ophthalmology

Long-term impact of Training the Trainers program on Primary Eye Care networks in Malawi using the Arclight Project package

A three-year follow-up study in Malawi reveals that while the Arclight Project's "Training the Trainers" model successfully established vertical mentorship networks and empowered Health Surveillance Assistants as community eye focal points, the long-term sustainability of these primary eye care networks requires intentional strategies to strengthen informal horizontal peer connections beyond mere skills transfer.

Windle, T., Maliko, F., Burgiss-Kasthala, S. + 1 more2026-04-02👁️ ophthalmology

Paving the way for automated transscleral cyclophotocoagulation: predicting ciliary body arc length from biometric data using a two-sphere eye model

This study introduces a biometric-based two-sphere eye model demonstrating that ciliary body arc length varies significantly among individuals, thereby challenging the standard 22 mm treatment assumption and highlighting the necessity of personalized calculations to ensure accurate fluence delivery in transscleral cyclophotocoagulation.

Szabo, A., Arpadffy-Lovas, T., Toth-Molnar, E.2026-03-31👁️ ophthalmology

Epidemiology and Associated Risk Factors of Diabetic Retinopathy in Patients with Diabetes Mellitus Attending a Tertiary-care Hospital in Hargeisa, Somaliland

This hospital-based cross-sectional study in Hargeisa, Somaliland, reveals a high 51% prevalence of diabetic retinopathy among diabetes patients, identifying age over 40, longer disease duration, marital and employment status, literacy, and concomitant cardiac illness as significant risk factors, thereby underscoring the urgent need for enhanced health policies and regular eye screening in the region.

Woredekal, A. T.2026-03-31👁️ ophthalmology

A Simplified Classification for Age-Related Macular Degeneration Based on Optical Coherence Tomography

This study introduces and validates the Stanford OCT-Based AMD Classification (SOAC), a simplified, standardized grading scheme that enables reliable and consistent age-related macular degeneration staging directly from optical coherence tomography images, achieving excellent intergrader agreement.

Yeh, T.-C., Lin, J. B., Mruthyunjaya, P. + 5 more2026-03-31👁️ ophthalmology

How 'Micro' is Microperimetry? - Characterizing the Effect of Fundus Tracking on the Psychometric Function

This study demonstrates that while fundus tracking in microperimetry primarily improves psychometric precision by reducing false positives and sharpening sensitivity curves at non-seeing retinal loci, it supports a defensible suprathreshold criterion intensity of 10 to 13 dB for distinguishing seeing from non-seeing retina.

Lipsky, T., Ehrenzeller, C., Ansari, G. + 4 more2026-03-27👁️ ophthalmology

Genomic network analysis links uveitis with systemic inflammatory diseases

This study demonstrates through genomic network analysis that uveitis shares significant genetic overlap and pathway similarities with systemic immune-mediated inflammatory diseases rather than primary ocular disorders, suggesting it is predominantly a systemic inflammatory condition with potential for endotype-specific therapies.

Chau, K., Allison, K., Braithwaite, T. + 2 more2026-03-26👁️ ophthalmology

Submission policy similarity and resubmission burden across the top 50 ophthalmology journals

This study analyzed submission policies across the top 50 ophthalmology journals and found that despite some common requirements, significant heterogeneity and modest similarity exist between journals, creating a substantial reformatting burden for authors resubmitting systematic reviews.

Kaleem, S., Tuitt-Barnes, D., Maxwell, O. + 1 more2026-03-24👁️ ophthalmology

Pre-diagnostic plasma endogenous steroids and the risk of exfoliation glaucoma

This nested case-control study found no statistically significant associations between pre-diagnostic plasma endogenous steroids and exfoliation glaucoma risk after multiple testing correction, though suggestive inverse trends for androgens and positive trends for progestogens warrant further investigation in larger studies.

Juramt, N., Ngo, Z. Z., Haslam, D. E. + 7 more2026-03-24👁️ ophthalmology

Whole-genome sequence genome-wide association study in All of Us identifies a novel glaucoma risk locus in African ancestry individuals

This study leverages whole-genome sequencing data from the diverse All of Us cohort to identify a novel glaucoma risk locus near *CYP2A7* specifically in African ancestry individuals, demonstrating the critical value of genetic diversity and refined phenotypic definitions in uncovering new genetic insights for primary open-angle glaucoma.

Aboobakar, I. F., Cruz, L. A., Kinzy, T. G. + 16 more2026-03-22👁️ ophthalmology

A Novel Arabic-Language Questionnaire to Assess Patient Satisfaction After Refractive Surgery

This cross-sectional study developed and validated a novel 25-item Arabic-language questionnaire, demonstrating its reliability and validity for assessing patient satisfaction following refractive surgery through factor analysis, Cronbach's alpha, and Rasch analysis.

Abozaid, M. A.2026-03-20👁️ ophthalmology

Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite alpha-ketoglutarate as a therapeutic strategy

This study utilizes multi-omics liquid biopsy to identify mitochondrial dysfunction as a hallmark of geographic atrophy and demonstrates that oral alpha-ketoglutarate supplementation can effectively modulate intraocular metabolites to potentially restore energy metabolism.

Yeh, T.-C., Velez, G., Prasad, A. + 14 more2026-03-19👁️ ophthalmology

Corrected Visual Acuity as the Foundation of Effective Myopia Control: A 1-Year Real-World Cohort Study in 9-Year-Old Children

This one-year real-world cohort study of 9-year-old children demonstrates that achieving normal corrected visual acuity with single-vision spectacles is essential for effectively slowing myopia progression, as under-correction or lack of correction leads to significantly faster axial elongation.

Zhang, Y., Mi, Q.-L., Xiao, H. + 4 more2026-03-19👁️ ophthalmology

Safety and Effectiveness of Iota-Carrageenan Eye Drops for the Treatment of Dry Eye Disease

This prospective clinical investigation demonstrates that four weeks of treatment with iota-carrageenan eye drops is safe, well-tolerated, and effective in significantly alleviating symptoms, stabilizing the tear film, and protecting the ocular surface in patients with mild-to-moderate dry eye disease, even under adverse environmental conditions.

Blanco Vazquez, M., Calonge, M., Dellago, H. + 4 more2026-03-18👁️ ophthalmology

Evolving Ocular Safety Signals of EGFR Inhibitors: A FAERS Disproportionality Analysis of Amivantamab, Mobocertinib, and Classic Agents

This study utilizes a FAERS disproportionality analysis to confirm a strong, class-wide signal of ocular toxicity ranging from benign eyelash abnormalities to sight-threatening complications across both classic and newer EGFR inhibitors, underscoring the critical need for proactive ophthalmologic monitoring in patients receiving these therapies.

Khan, Z. S., Nadel, A., Joly, T. J.2026-03-18👁️ ophthalmology

From Blurry to Brilliant: HAGAN, a Hybrid Attention GAN for Home-Based OCT Image Enhancement with Magical Results

This paper introduces HAGAN, a hybrid attention generative adversarial network that significantly enhances the quality of noisy, low-resolution home-based OCT images acquired via the Siloton device, thereby enabling reliable remote retinal monitoring and reducing the need for frequent clinical visits.

Arian, R., Kafieh, R.2026-03-17👁️ ophthalmology

Adaptations and interpretation of Intelligence Tests for Adults with Visual Impairment: A Literature Review and Interviews with Healthcare Professionals

This mixed-method study reveals that no valid, standardized intelligence tests or norm-groups currently exist for adults with visual impairment, leading healthcare professionals to rely on verbal subtests and ad-hoc adaptations while highlighting an urgent need for tailored assessment tools.

Lamper, C., Onnink, M., Buijsen, M. v. + 2 more2026-03-16👁️ ophthalmology