👁️ Category

ophthalmology

33 papers

Ophthalmology explores the intricate world of vision, covering everything from common eye conditions like cataracts and glaucoma to complex genetic disorders affecting sight. This field bridges critical gaps between basic biology and clinical care, aiming to preserve and restore one of our most vital senses. On Gist.Science, we focus on the latest breakthroughs emerging directly from the research community before they reach traditional journals.

Every new preprint in this category comes from medRxiv, where scientists share their urgent findings early. We process each of these submissions to provide both accessible plain-language explanations and detailed technical summaries, ensuring that complex discoveries about eye health are understandable to everyone, from patients to specialists. Below are the latest papers in ophthalmology, offering a fresh look at how researchers are tackling vision loss and improving eye care today.

👁️ ophthalmology

Patient preferences for portable versus table-mounted visual field devices in rural Alabama: a mixed methods study within a telemedicine setting

In a mixed-methods study of rural Alabama patients, portable visual field devices, particularly virtual reality-based systems, were significantly preferred over traditional table-mounted equipment due to superior comfort, ease of use, and immersive visual experiences, suggesting their potential to enhance patient-centered glaucoma monitoring in telemedicine settings.

Antwi-Adjei, E. K., Datta, S., Girkin, C. A., Owsley, C., Rhodes, L. A., Fifolt, M., Racette, L.2026-04-25
👁️ ophthalmology

Multidrug Antifungal Resistance and Clinical Outcomes in Fungal Keratitis: A Prospective Study in a South Indian Population

A prospective study of fungal keratitis patients in South India revealed high rates of multidrug resistance, particularly among *Fusarium* and *Aspergillus* isolates, with natamycin resistance significantly correlating with poorer clinical outcomes and underscoring the need for species-specific treatment thresholds.

Fingerhut, L., Vigneshwar, R., Burte, F., Devi, M. V., Nagarajan, R. S., Karpagam, R., Prajna, V., Mills, B., Lalitha, P (…)2026-04-20
👁️ ophthalmology

Feasibility of smartphone-based digital phenotyping to measure visual function and mental health outcomes in patients with inherited retinal diseases

This 12-month study demonstrates that the OverSight iOS application is a feasible tool for collecting passive and active digital phenotyping data in patients with inherited retinal diseases, revealing promising associations between behavioral markers like mobility and typing patterns with visual function and mental health outcomes.

Jones, L., Higgins, B., Devraj, K., Crabb, D., Thomas, P., Moosajee, M.2026-04-15
👁️ ophthalmology

Association of axial length and changes in aqueous depth with refractive outcomes in Chinese primary angle closure glaucoma patients

This study demonstrates that in Chinese primary angle closure glaucoma patients undergoing phacoemulsification, axial length and the pre- to post-surgical change in aqueous depth are significantly associated with intraocular lens power calculation errors, suggesting that accurately predicting these changes is crucial for optimizing refractive outcomes, particularly in acute cases with an axial length of 22 mm or greater.

Wang, L., Yang, Y., Ng, T. K., Chen, J., Sun, X.2026-04-14
👁️ ophthalmology

Persistent Cytotoxic Immune Signaling in Anti-VEGF-Treated Neovascular Age-Related Macular Degeneration

This study reveals that neovascular age-related macular degeneration patients treated with anti-VEGF therapy exhibit persistent cytotoxic immune signaling in the vitreous, suggesting that VEGF-independent immune mechanisms drive ongoing retinal damage and highlighting the potential for combination therapies targeting both angiogenic and immune pathways.

Toral, M. A., Ng, B., Velez, G., Yang, J., Tsang, S. H., Bassuk, A. G., Mahajan, V. B.2026-04-13
👁️ ophthalmology

Efficacy of Highly Aspherical Lenslet (HAL) spectacles in slowing myopia progression in children and adolescents: A multi-centre, retrospective, real-world study in India-SOLIDITY study

This multi-centre retrospective study in India demonstrates that Highly Aspherical Lenslet (HAL) spectacles significantly slowed myopia progression by approximately 83% and axial elongation by 62% in children and adolescents aged 4 to 16 years compared to expected physiological rates.

Saxena, R., Jethani, J., Roy, L., Matalia, J., Verkicharla, P. K., Ganesh, S., Parthasarathy, A., Nayak, S., Gupta, V. (…)2026-04-13
👁️ ophthalmology

Impact of Socioeconomic Status on Clinical Features and Outcomes of Bacterial Keratitis: The Midlands Infectious Keratitis Study

This retrospective multicentre study of 320 patients in the UK found that socioeconomic deprivation does not significantly influence the clinical presentation or outcomes of bacterial keratitis, suggesting that universal access to emergency ophthalmic care may attenuate potential disparities in this sight-threatening condition.

Javed, K. M. A. A., Ozturk, B., Anwar, S., Butt, G., Low, L., Said, D. G., Dua, H. S., Rauz, S., Ting, D. S. J.2026-04-07
👁️ ophthalmology

Long-term impact of Training the Trainers program on Primary Eye Care networks in Malawi using the Arclight Project package

A three-year follow-up study in Malawi reveals that while the Arclight Project's "Training the Trainers" model successfully established vertical mentorship networks and empowered Health Surveillance Assistants as community eye focal points, the long-term sustainability of these primary eye care networks requires intentional strategies to strengthen informal horizontal peer connections beyond mere skills transfer.

Windle, T., Maliko, F., Burgiss-Kasthala, S., Blaikie, A.2026-04-02
👁️ ophthalmology

Epidemiology and Associated Risk Factors of Diabetic Retinopathy in Patients with Diabetes Mellitus Attending a Tertiary-care Hospital in Hargeisa, Somaliland

This hospital-based cross-sectional study in Hargeisa, Somaliland, reveals a high 51% prevalence of diabetic retinopathy among diabetes patients, identifying age over 40, longer disease duration, marital and employment status, literacy, and concomitant cardiac illness as significant risk factors, thereby underscoring the urgent need for enhanced health policies and regular eye screening in the region.

Woredekal, A. T.2026-03-31