314 papers
This large-scale Mendelian randomisation study identifies adiposity and specific lipid metabolites as key causal drivers of systemic inflammation, revealing that CRP serves as a broad, integrated readout of inflammatory burden influenced by diverse metabolic traits, whereas IL-6 reflects a more tightly regulated process primarily driven by adiposity.
This post hoc analysis of the National Lung Screening Trial developed four distinct, personalized risk models incorporating screening history and timing of diagnosis to predict lung cancer incidence across prevalence, interval, and screen-detected subgroups, identifying specific risk factors beyond standard age and smoking criteria that could enhance individualized screening management.
This study uses statistical modeling of over 20 years of data to demonstrate that anthropogenic climate change drove a 34% increase in dengue incidence across Brazil during the record-hot 2023/24 season, highlighting how temperature anomalies differentially expanded the disease's range in southern regions while suppressing it in northern areas.
This paper demonstrates that harmonizing and spatially analyzing historical morbidity data alongside mortality records for the 1918–1920 influenza pandemic in Switzerland reveals distinct influencing factors for each, arguing that studying both dimensions is essential for a comprehensive understanding of pandemic dynamics and encouraging researchers to overcome data limitations to include morbidity in their analyses.
This study demonstrates that incorporating wearable-derived physiological features, such as heart rate, activity, and sleep patterns, significantly improves the classification and risk stratification of multiple chronic physical and mental health conditions in a large longitudinal real-world dataset, with particularly strong gains observed for major depressive disorder and anxiety.
This 2024 cross-sectional analysis of national surveillance data reveals that while the majority of people accessing sexual health services in England tested only once, frequent quarterly testing remains low even among high-risk groups like GBMSM and PrEP users, highlighting a critical gap between current testing recommendations and actual practice.
This study demonstrates that the non-genetic component of adult height, derived as a residual from genetically predicted height, serves as a valid surrogate marker for childhood socioeconomic position and is positively associated with cardiovascular and brain health in middle-aged and older adults within the Hispanic Community Health Study/Study of Latinos.
A 2025 convenience survey of 235 community members in Victoria, Australia, revealed generally high levels of comfort and acceptability regarding participation in household transmission investigations, including data collection and companion animal involvement, despite the sample's non-representative demographic profile.
This study analyzes 2,492 SARS-CoV-2 genomes from Laos between 2021 and 2024 to reveal how the relaxation of travel restrictions shifted viral transmission from a few initial introductions to numerous independent entries driving successive waves of Alpha, Delta, and Omicron variants, thereby highlighting the critical role of genomic surveillance in guiding public health responses.
This population-based study of nearly 3,000 children and adolescents in Quebec reveals that time to cancer diagnosis varies significantly by cancer type, age, and geographic location, with the longest delays for carcinomas and shortest for leukemias, while also noting that diagnostic intervals shortened for several cancer types in the post-pandemic period.