15 papers
This study demonstrates that the CellSearch CMMC assay is a highly sensitive, analytically validated liquid biopsy platform capable of non-invasive, longitudinal minimal residual disease monitoring in multiple myeloma, offering a patient-friendly alternative to reduce the reliance on invasive bone marrow biopsies.
This single-cell analysis of daratumumab-treated primary AL amyloidosis patients reveals that suboptimal responders harbor amyloidogenic plasma cells with distinct stress signatures and foster an inflammatory-immunosuppressive bone marrow niche driven by prostaglandin-mediated myeloid expansion and non-classical MHC I interactions, which collectively impair immune function and drive treatment resistance.
This study utilizes single-cell RNA sequencing of bone marrow samples from 19 patients to characterize the transcriptomic spectrum, immune microenvironment interactions, and light-chain subtype-specific differences in plasma cells, revealing how cellular heterogeneity and specific ligand-receptor dynamics drive disease progression and influence clinical outcomes in light chain amyloidosis.
In a blinded evaluation of 30 complex myelodysplastic syndrome cases, a rule-bound, multi-agent AI system (VMP) significantly outperformed general-purpose large language models by achieving expert-level accuracy and drastically reducing major clinical errors, demonstrating its potential as a safe decision-support tool for precision hematology care.
A survey of 17 European blood establishments reveals that while there is significant potential and interest in creating "vein-to-vein" datasets linking donors, products, and recipients for the PETRA project, realizing this infrastructure is currently hindered by legal constraints, consent issues, and resource limitations.
This study demonstrates that applying AI techniques, specifically clustering and self-supervised autoencoders, to raw single-cell blood count data can uncover novel, clinically prognostic biomarkers that capture subtle physiologic signals and predict outcomes like mortality and disease development more effectively than traditional summary metrics.
This study demonstrates that MDS patients with chromosome 7 abnormalities (-7/-7q) exhibit haploinsufficiency of the NAMPT gene, rendering their leukemic blasts uniquely sensitive to NAMPT inhibition, particularly when combined with venetoclax, thereby establishing NAMPT haploinsufficiency as a therapeutic vulnerability and biomarker for this high-risk subset.
This study demonstrates that functional annotation of monoallelic TP53 mutations using a phenotype score significantly refines prognostic stratification in myelodysplastic neoplasms, revealing that patients with high-risk functional variants and elevated variant allele frequencies have outcomes comparable to multi-hit cases, while those with low-risk profiles exhibit survival similar to wild-type patients.
A comparative study conducted at Aniniwaa Medical Centre in Kumasi found that while portable hemoglobin meters offer 100% sensitivity for anemia screening, they significantly underestimate hemoglobin levels and overestimate prevalence compared to the more accurate and reliable fully automated analyser.
This study integrates multi-omics data to establish the first genomic atlas of the autoimmune-thrombotic axis, revealing that vasculature-specific gene regulation drives shared genetic susceptibility between autoimmune diseases and venous thromboembolism while identifying causal links and repurposing TNF inhibitors as potential therapeutic targets.
This study identifies a novel pathogenic mechanism in sickle cell disease where substance P triggers acute chest syndrome by activating and recruiting mast cells and basophils to the lungs, leading to lethal inflammation and pain.
This study demonstrates that quantifying HLA evolutionary divergence (HED) in 9/10 mismatched unrelated donor transplants reveals significant within-mismatch heterogeneity and complex, locus-specific interactions that independently predict clinical outcomes such as relapse-free survival, graft-versus-host disease, and mortality, thereby complementing conventional mismatch classification.
This study demonstrates that Liquid Plasma, despite showing reduced levels of Factors V, VII, and VIII and Protein S compared to Thawed Plasma by its expiration date, maintains adequate fibrinogen and Protein C activity, supporting its viability as an alternative for emergency and massive transfusions.
This double-blind, randomized study demonstrates that daily low-dose supplementation with either >Your< Iron Forte Capsules or Ferrous Sulfate effectively improves iron status in adults with dietary iron deficiency, with the former offering a potentially superior safety profile characterized by fewer and less severe gastrointestinal adverse events.
This study develops and internally validates the AB-IPI, a novel prognostic score integrating host fitness (albumin), tumor burden (IPI), and tumor biology (BCL2) to improve risk stratification and therapeutic decision-making for R-CHOP-treated diffuse large B-cell lymphoma patients beyond the limitations of the standard IPI.