A Restricted Latent Class Model with Polytomous Attributes and Respondent-Level Covariates

This paper introduces an exploratory restricted latent class model that accommodates polytomous responses, ordinal multi-attribute states with correlated attributes via a multivariate probit specification, and respondent-level covariates, demonstrating its effectiveness in recovering parameters and revealing complex latent structures in depression diagnosis beyond traditional single-factor approaches.

Eric Alan Wayman, Steven Andrew Culpepper, Jeff Douglas + 1 more2026-03-10📊 stat

Intrinsic Geometry-Based Angular Covariance: A Novel Framework for Nonparametric Changepoint Detection in Meteorological Data

This paper introduces a novel nonparametric framework for detecting changepoints in the mean direction of toroidal and spherical meteorological data by leveraging intrinsic geometry to define a curved dispersion matrix and Mahalanobis distance, establishing the statistical properties of the proposed tests and validating them on wind-wave directions and cyclonic storm paths.

Surojit Biswas, Buddhananda Banerjee, Arnab Kumar Laha2026-03-10📊 stat

Inferring the dynamics of quasi-reaction systems via nonlinear local mean-field approximations

This paper proposes a nonlinear local mean-field approximation method that utilizes a first-order Taylor expansion of hazard rates to enable efficient and robust parameter estimation for quasi-reaction systems, particularly outperforming existing SDE and ODE-based approaches when dealing with large time gaps between observations and stiff biological dynamics.

Matteo Framba, Veronica Vinciotti, Ernst C. Wit2026-03-10🧬 q-bio

Identifying Treatment Effect Heterogeneity with Bayesian Hierarchical Adjustable Random Partition in Adaptive Enrichment Trials

This paper introduces the Bayesian Hierarchical Adjustable Random Partition (BHARP) model, a self-contained framework that utilizes a finite mixture model and reversible-jump Markov chain Monte Carlo sampling to automatically identify treatment effect heterogeneity and adjust information borrowing in adaptive enrichment trials, thereby outperforming existing methods in accuracy and precision.

Xianglin Zhao, Shirin Golchi, Jean-Philippe Gouin + 1 more2026-03-06📊 stat

Bayesian Inference for PDE-based Inverse Problems using the Optimization of a Discrete Loss

This paper introduces B-ODIL, a Bayesian extension of the Optimization of a Discrete Loss (ODIL) method that integrates PDE-based prior knowledge with data likelihood to solve inverse problems with quantified uncertainties, demonstrating its effectiveness through synthetic benchmarks and a clinical application for estimating brain tumor concentration from MRI scans.

Lucas Amoudruz, Sergey Litvinov, Costas Papadimitriou + 1 more2026-03-06🔬 physics

Proximal Learning for Trials With External Controls: A Case Study in HIV Prevention

This paper introduces novel proximal causal inference methods that leverage external control data and negative control variables to reliably estimate counterfactual placebo outcomes and demonstrate the superior efficacy of cabotegravir in active-controlled HIV prevention trials, effectively addressing challenges posed by unmeasured risk differences and low event rates.

Yilin Song, Yinxiang Wu, Raphael J. Landovitz + 9 more2026-03-06📊 stat