Robust evaluation of treatment effects in longitudinal studies with truncation by death or other intercurrent events

This paper proposes the Pairwise Last Observation Time (PLOT) estimand, a novel, assumption-free causal inference method that robustly evaluates treatment effects in longitudinal studies by comparing matched individuals at their last common observation time before intercurrent events, thereby avoiding the unverifiable assumptions and sensitivity issues inherent in existing frameworks.

Georgi Baklicharov, Kelly Van Lancker, Stijn VansteelandtThu, 12 Ma📊 stat

Constructing Evidence-Based Tailoring Variables for Adaptive Interventions

This paper proposes a systematic framework for empirically developing evidence-based tailoring variables for adaptive interventions, arguing that while secondary data can be used, specifically designed optimization experiments (such as SMARTs or factorial designs) provide the most direct causal evidence for determining optimal measurement times, decision points, and cutoffs.

John J. Dziak, Inbal Nahum-ShaniThu, 12 Ma📊 stat

Causal Meta-Analysis: Rethinking the Foundations of Evidence-Based Medicine

This paper proposes a causal framework for meta-analysis that introduces novel aggregation formulas for nonlinear effect measures to address the limitations of conventional methods, revealing that standard approaches can sometimes misleadingly suggest treatment benefits where causal effects are actually harmful.

Clément Berenfeld, Ahmed Boughdiri, Bénédicte Colnet, Wouter A. C. van Amsterdam, Aurélien Bellet, Rémi Khellaf, Erwan Scornet, Julie JosseThu, 12 Ma📊 stat

Impact of existence and nonexistence of pivot on the coverage of empirical best linear prediction intervals for small areas

This paper advances the theory of small area prediction intervals by analytically demonstrating that the coverage error of empirical best linear predictors depends critically on the existence of a pivot, revealing that standard parametric bootstrap methods fail to achieve optimal O(m3/2)O(m^{-3/2}) accuracy without it and proposing a double parametric bootstrap approach to correct this deficiency.

Yuting Chen, Masayo Y. Hirose, Partha LahiriThu, 12 Ma📊 stat

Nonparametric estimation of a state entry time distribution conditional on a "past" state occupation in a progressive multistate model with current status data

This paper proposes and evaluates two nonparametric methods for estimating state entry time distributions and occupation probabilities in progressive multistate models with current status data, addressing the challenges of interval censoring through fractional at-risk sets and marginal probability ratios, and demonstrating their effectiveness via simulations and a breast cancer case study.

Samuel Anyaso-Samuel, Somnath DattaThu, 12 Ma📊 stat

Sequential Causal Normal Form Games: Theory, Computation, and Strategic Signaling

This paper extends Causal Normal Form Games to sequential settings by introducing Sequential Causal Multi-Agent Systems, but its comprehensive theoretical and empirical analysis reveals that, under standard rational assumptions, these causal frameworks offer no welfare advantage over classical Stackelberg equilibrium, thereby highlighting a fundamental incompatibility between rational choice and causal reasoning benefits in current game-theoretic models.

Dennis ThummThu, 12 Ma📊 stat

Causal Concept Graphs in LLM Latent Space for Stepwise Reasoning

This paper introduces Causal Concept Graphs (CCG), a framework that combines task-conditioned sparse autoencoders with differentiable structure learning to map causal dependencies between interpretable latent features in LLMs, demonstrating through the Causal Fidelity Score that graph-guided interventions significantly enhance stepwise reasoning performance compared to existing tracing and random baselines.

Md Muntaqim Meherab, Noor Islam S. Mohammad, Faiza FerozThu, 12 Ma🤖 cs.LG

Controlling the joint local false discovery rate is more powerful than meta-analysis methods in joint analysis of summary statistics from multiple genome-wide association studies

This paper proposes a novel summary-statistics-based joint analysis method that controls the joint local false discovery rate (Jlfdr), demonstrating through simulations and empirical data that it offers superior power over traditional meta-analysis methods, particularly when analyzing heterogeneous genome-wide association study datasets.

Wei Jiang, Weichuan YuThu, 12 Ma📊 stat

Don't Disregard the Data for Lack of a Likelihood: Bayesian Synthetic Likelihood for Enhanced Multilevel Network Meta-Regression

This paper proposes a Bayesian Synthetic Likelihood (BSL) framework integrated with Hamiltonian Monte Carlo to enhance Multilevel Network Meta-Regression by leveraging available subgroup-level summary statistics to impute missing individual-level covariates, thereby improving population-adjusted treatment comparisons in the presence of incomplete data.

Harlan Campbell, Charles C. Margossian, Jeroen P. Jansen, Paul GustafsonThu, 12 Ma📊 stat