Optimizing Complex Health Intervention Packages through the Learn-As-you-GO (LAGO) Design
Cet article présente la conception Learn-As-you-GO (LAGO), une méthodologie innovante qui optimise les paquets d'interventions de santé complexes en les adaptant dynamiquement au fil de l'étude pour garantir leur efficacité et leur puissance statistique tout en minimisant les coûts et les risques d'échec, comme l'illustrent les études BetterBirth et d'autres essais en cours.
Donna Spiegelman (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Dong Roman Xu (Southern Medical University Institute for Global Health), Ante Bing (Department of Mathematics,Statistics, Boston University), Guangyu Tong (Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University), Mona Abdo (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Jingyu Cui (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Charles Goss (Center for Biostatistics,Data Science, Washington University School of Medicine), John Baptist Kiggundu (Infectious Diseases Research Collaboration), Chris T. Longenecker (Division of Cardiology,Department of Global Health, University of Washington), LaRon Nelson (Yale School of Nursing, Yale University), Drew Cameron (Department of Health Policy,Management, Yale University), Fred Semitala (Infectious Diseases Research Collaboration,,Department of Medicine, Makerere University,,Makerere University Joint AIDS Program), Xin Zhou (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Judith J. Lok (Department of Mathematics,Statistics, Boston University)Mon, 09 Ma📊 stat