📄 medicine

Histopathological Evaluation of the Cardioprotective Effects of Ten Medicinal Plants in a Rat Model of Isoproterenol-Induced Heart Failure

本研究表明,以积雪草(*Centella asiatica*)为代表的十种药用植物的预处理,显著减轻了心力衰竭大鼠模型中异丙肾上腺素诱导的心脏组织病理学损伤(包括纤维化和坏死),从而为这些植物的护心潜力提供了至关重要的组织层面证据。

Seyed Ahmad Mohajeri, Shirin Taraz Jamshidi, Faeze Keihanian, Amin Saeidinia, Saeid Madaeni2026-09-08
📄 medicine

An oncolytic reovirus-based platform amenable to oral vaccination

本研究展示了一种安全的、减毒活性的 3 型呼肠孤病毒(Reovirus Type 3)Dearing 平台,该平台通过在其 σ1 蛋白上展示多样化的抗原,通过口服给药激发强大的全身性和黏膜免疫,证明了其在预防和治疗传染病及癌症方面的强大效力。

Tommy Alain, Salar Pashangzadeh, Xiao Xiang, Nikolas Martin, Yang Long, Ki-Hoon Song, Negar Sharifi, Eknoor Walia, Seran (…)2026-09-08
📄 medicine

Sport participation as a mediating factor between substance use and self-harming behaviour among Australian adolescents: a prospective cohort study

这项针对澳大利亚青少年的前瞻性队列研究发现,团队运动的参与(而非个人运动)中介了酒精和烟草使用与随后的自残或自杀倾向之间的关联,这表明团队运动的社交层面可能在抵御这些心理健康风险方面发挥着保护作用。

Kylie Atkinson, Katherine McGill, Alexandra Martiniuk, Md Irteja Islam2026-09-07
📄 medicine

Bridging Knowledge but Not Yet Action: A Kirkpatrick-based Evaluation of Simulation Training for Local Anesthetic Systemic Toxicity Management

虽然基于模拟的跨学科培训项目显著提高了外科住院医师在局部麻醉系统毒性(LAST)管理方面的理论知识,使其优于麻醉科住院医师,但这一提升并未转化为在危机模拟中更优越的实际操作表现,从而凸显了通过长期的临床暴露和定期的再培训来弥合知识与反射性行动之间差距的关键必要性。

Faruk Cicekci, Mehmet Can Yuruk, Mehmet Selcuk Uluer, Mehmet Sargin, Emine Aslanlar, Ahmet Hilmi Guluc, Muslu Kazım Kore (…)2026-09-07
📄 medicine

The Association between Pre-existing Mental Health Conditions and Neurodevelopmental Disorders and Post-concussion Functional Impairment and Disability: A Cross-sectional Analysis

这项针对安大略省脑震荡患者的横断面分析表明,预先存在的精神健康状况和神经发育障碍与增加的脑震荡后症状负担及功能障碍显著相关,强调了对这些高风险个体进行针对性早期康复干预的必要性。

Umme Saika Kabir, Vicki L Kristman, Heather M MacKenzie, Cindy Hunt, CONNECT Executive Team2026-09-07
📄 medicine

Implementation Evaluation of a Diabetes Prevention Program Training Adolescents in Low-Income Communities to be Health Coaches for Family Members

这项实施性研究表明,斯坦福青少年糖尿病教练项目(SYDCP)有效地赋能了低收入社区的青少年,使其成为家庭健康教练,在显著提升健康知识、行为和心理社会资产的同时,也通过强大的学术-社区伙伴关系凸显了该项目的适应性和可行性。

Liana Gefter, Ashini Srivastava, Can Angela Jiang, Nancy Morioka-Douglas, Eunice Rodriguez2026-09-07
📄 medicine

Peripheral inflammatory biomarkers for individualized preoperative prediction of meningioma-related epilepsy in patients with frontal meningioma: a retrospective cohort study

这项针对222例额叶脑膜瘤患者的回顾性队列研究确定了术前中性粒细胞和血小板计数是脑膜瘤相关癫痫的独立预测因子,并开发了一个用于个体化风险评估的简洁且具解释性的列线图,但在临床应用前仍需进行外部验证。

Xiang Zan, Chenlong Niu, Yujia Yang, Tian Wei, Pengfei Zhang, Hao Li, Peili Cao, Jiuhong Ma2026-09-07
📄 medicine

Inconsistent and divergent large language model safety guidance during intraoperative crises: a guideline- anchored benchmark

这项研究表明,前沿大语言模型在模拟术中危机时,在提供基于指南的安全指导方面表现出显著的不一致性和差异性,特别是在沟通与升级处置方面,这凸显了评估其可靠性和可重复性而非仅仅评估其综合准确性的必要性,以用于临床决策支持。

Brian H. Park, Claire S. Soria, Preetham Suresh, Ryan Broderick, Bryan Sandler2026-09-07