📄 medicine

Tumor angiogenesis proteome dynamic changes across different grades of gliomas: Analysis within the framework of 3P medical approaches

本研究利用激光捕获显微切割和多组学分析来绘制跨肿瘤等级的胶质瘤血管生成的动态蛋白质组图谱,识别阶段特异性生物标志物,并验证经FDA批准的抗肿瘤药物的有效性,以推进胶质瘤管理的预测、预防和个性化医学(3PM)策略。

Zhijun Li, Tianyao Guo, Jingjing Wang, Xuejun Li, Lamei Yang, Tao Xin, Na Li, Xianquan Zhan2026-09-07
📄 medicine

A national forensic study examines recorded suicide mortality trends geographical distribution and methods in Botswana from 2014 to 2025

这项在博茨瓦纳开展的国家法医研究(2014–2025年)显示,记录在案的自杀死亡率显著上升,尤其是在2023年至2025年期间,这可能部分归因于数据采集能力的提升而非死亡人数的真实增加,凸显了对综合国家监测系统的紧迫需求。

Shathani Mugoma, Mooketsi Molefi, Jaemin Jeon, Gormao Lee, Leano Phetogo, Gosaitse Thokwana, Elora Shakoor, Sawyer Strib (…)2026-09-07
📄 medicine

Copper-Induced Neurotoxicity Management Through ATP7B-Guided In Silico Screening and In vitro Validation of Silymarin-Loaded Liposomal Hydrogel

本研究开发并验证了一种通过 ATP7B 指导的计算机模拟筛选确定的水飞蓟素负载脂质体热敏鼻腔水凝胶,作为一种极具前景的治疗平台,用于通过有效减轻体外铜诱导的神经毒性和氧化应激来管理威尔逊病。

Priyanshu Rajesh Dubey, Ashish Dilip Sutar, Shivam Gajananrao Aghade, Rewati Raman Ujjwal, Beauty Behera, Rahul Shukla2026-09-07
📄 medicine

Rapid convenience monitoring as a method to assess immunization status and programmatic reach across different age groups during the Big Catch-up: Experiences from 8 countries

本文总结了八个国家利用快速便利监测(RCM)作为一种面向实地的工具,在“大追赶”行动期间快速评估免疫接种状况、识别不同年龄段的漏种儿童及障碍因素,并推动即时项目行动的经验。

Ariel Higgins-Steele, Hadiatou Diallo, Stephanie Shendale, Salahuddin Sadi, Anvar Nazurdinov, Eric Rurangwa, Amidou Zong (…)2026-09-07
📄 medicine

Association of serum electrolyte levels with duration of labor in southwest China: A large hospital-based population study

这项在华西南地区开展的大型医院研究表明,母体血清电解质水平,特别是钾、钠、氯、镁和钙,与第一产程和第二产程的持续时间及延长风险显著相关,这提示监测并管理电解质平衡可能有助于优化分娩结局。

Rui Tan, Kunming Tian, Lei Bai, Lei Luo, Zhongbao Chen, Haiyan Wang, Boyi Yang, Shimin Xiong, Yijun Liu, Xingyan Liu, Ma (…)2026-09-07
📄 medicine

Acute Neurophysiological Effects of Transcutaneous Auricular Vagus Nerve Stimulation in Chronic Insomnia Disorder

这项随机、伪刺激对照试验表明,在患有慢性失眠障碍的成年人中,急性经皮耳介迷走神经刺激会诱发中枢阿尔法波和额叶西塔波脑电功率的即时、区域特异性增加,且不改变规范微状态拓扑结构,这提示其作用机制涉及对过度觉醒的振荡调节,而非大规模网络重构。

Tianyi Yan, Wenhao Chen, Anshun Kang, Yan Zhou, Tingting Gu, Jinfeng Duan, Qiwen Luo, Ruobing Liu, Jian Ouyang, Zilong Y (…)2026-09-07