🧬 biology

Spatiotemporal multi-omics reveal ISG15⁺ T cells as a predictive transitional state in cancer immunotherapy

通过整合 39 种癌症的多组学与空间图谱分析,本研究将 ISG15⁺ T 细胞重新定义为一种“蓄势待发”的过渡性储备库,它们在空间上被束缚在肿瘤核心区域,但可以通过免疫检查点阻断被动员为活跃的效应细胞,从而作为治疗成功的强效预测生物标志物。

Taiwen Li, Guile Zhao, Yiwen Lu, Hao Cui, Grace Lubamba, Zhongzheng Xiang, YingYing Lian, Yang Yang, Siying Zuo, Shouzhe (…)2026-07-06
🧬 biology

Activation of the innate immune system of the Antarctic sea urchin Sterechinus neumayeri by soluble fraction of diesel oil and high seawater temperature

本研究表明,暴露于柴油的水溶性部分,特别是在高浓度且结合海水温度升高的条件下,会显著激活南极海胆(*Sterechinus neumayeri*)的先天免疫系统,这通过吞噬活性和特定的体腔细胞反应的增强得到了证实。

José Roberto Machado Cunha Silva, João Carlos Shimada Borges, Renata Stecca Iunes, Marina Tenório Botelho, Leandro Nogue (…)2026-07-06
🧬 biology

Core functional convergence and spatiotemporal complementarity of soil microbial communities between rhizosphere and decomposing habitats in Foding Mountain Nature Reserve, China

这项研究表明,在佛顶山自然保护区内,宿主植物对根际微生物组发挥着双向调节作用,同时真菌与细菌在有机质分解过程中采用时空互补策略并具有不同的功能角色,共同驱动了亚热带森林生态系统的物质循环与功能维持。

Jinhua Xu, Xinghong Wang, Anxiong Wei, Qingsong Ran, Haiyan Wang, Chunbo Dong, Yanwei Zhang, Wanhao Chen, Yanfeng Han2026-07-06
🧬 biology

Neuronal Mitochondrial Dysfunction Drives Astrocytic Mitochondrial Transfer after TBI: Reveals the Therapeutic Potential of astrocytic EV-Mito

在创伤性脑损伤后,神经元线粒体功能障碍会触发一种由星形胶质细胞介导的适应性反应,即通过细胞外囊泡转移线粒体以恢复胞体和神经突的生物能量学,尽管这种保护机制未能到达突触。

Gopal V Velmurugan, Hemendra J Vekaria, Alexander G Rabchevsky, Kai Saito, Josh M Morganti, Samir Patel, Brad Hubbard, P (…)2026-07-06
🧬 biology

Root water-uptake depth and leaf trait adjustments along a water table gradient: trade-offs among trees and shrubs in a tropical coastal forest

这项研究表明,在热带海岸休息林(restinga forests)中,树木和灌木通过调整根系吸水深度以响应地下水位变化来维持水分状态,但这种地下投资产生了一种权衡,专门限制了树木的地上部分光合特征和绿度。

Cristina Antunes, Sergio Chozas, Rafael Flora, Cristina Máguas, Carlos Joly, Simone Vieira2026-07-06