281 papers
Bioengineering sits at the vibrant intersection of biology and engineering, where scientists design new tools to understand life and solve real-world problems. From creating artificial organs to developing smart materials that mimic natural tissues, this field turns complex biological questions into tangible innovations that improve human health and our environment.
At Gist.Science, we track every new preprint in this category directly from bioRxiv. Our team processes each submission to provide both plain-language explanations for curious minds and detailed technical summaries for researchers, ensuring these cutting-edge discoveries are accessible to everyone. Below are the latest papers in bioengineering that have recently appeared on bioRxiv.
This paper introduces RDBCycleGAN-CBAM, a novel deep learning model that integrates residual dense blocks and convolutional block attention modules into a CycleGAN framework to significantly improve the quality of low-dose CT images while preserving structural details and reducing radiation exposure.
This study introduces a novel therapeutic strategy using bispecific antibody "Shedders" to recruit the protease ADAM10 to cell-surface proteins, inducing selective extracellular domain shedding that bypasses lysosomal trafficking and effectively reinvigorates immune responses, as demonstrated by the depletion of LAG-3 and other immune receptors.
This paper introduces MicrowellMicrofluidicsMiner (M3), a framework leveraging large language model agents to autonomously extract and curate microwell microfluidics design parameters from unstructured literature, achieving a 78% accuracy rate that significantly outperforms standalone models and facilitates data-driven device optimization.
This paper introduces a microfluidic agarose microdroplet platform that enables high-throughput DNA-encoded library screening of chromatin-associated targets within a near-native cellular context by combining mechanical stability, selective protein retention via mild permeabilization, and efficient ligand diffusion.
This study presents a zwitterionic polymer-coated multimodal microelectrode array that enables stable, chronic simultaneous detection of dopamine and electrophysiological signals in freely moving mice over four weeks by effectively mitigating biofouling and ensuring reference electrode stability.
This paper introduces SLEEC, a semi-supervised learning framework that leverages multiple sequence alignment-based data augmentation to achieve state-of-the-art enzyme classification performance while providing interpretable residue-level annotations and robustness to common sequence modifications.
This paper introduces an AI-powered, label-free pipeline using Holo-Tomographic Flow Cytometry and fractal analysis to profile the co-occurrence and severity of multiple morphological phenotypes in vacuolated cells through a unique 7-digit classification code.
The Virtual Immersion in Biomedical Engineering (VIBE) program provides a scalable, free, and inclusive online platform that enables undergraduate students worldwide to develop engineering design skills and global competencies through collaborative, culturally sensitive virtual experiences.
The authors introduce CARBONITE, a scalable single-cell imaging framework that pairs live calcium dynamics with protein expression to reveal that cardiomyocyte identity and functional heterogeneity are driven by factors such as nuclear state rather than just canonical subtype markers.
This study demonstrates that flexible polyimide probes cause significantly less tissue damage and immune reactivity than stiff silicon probes in mouse cerebral cortex, highlighting the critical role of material flexibility and implantation depth in optimizing long-term neurodevice integration.