💻 Category

bioinformatics

1200 papers

Bioinformatics sits at the exciting intersection where biology meets data science, using powerful computer tools to decode the vast complexity of living systems. From mapping the human genome to tracking how viruses evolve, this field transforms raw biological information into actionable insights that drive modern medicine and research forward without requiring a supercomputer to understand the basics.

On Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category directly from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge discoveries accessible to everyone regardless of their background.

Below are the latest bioinformatics papers added from bioRxiv, ready for you to explore with clarity and depth.

💻 bioinformatics

A phylogenetic approach reveals evolutionary aspects and novel genes of bradyzoite conversion in Toxoplasma gondii

By employing a phylogenetic comparison of proteomes between cyst-forming Sarcocystidae and non-cyst-forming Eimeriidae parasites, this study identifies distinct conservation patterns of *Toxoplasma gondii* proteins and pinpoints a specific cluster of bradyzoite-conserved proteins as a promising source for discovering novel genes involved in bradyzoite differentiation.

C A, A., Upadhayay, R., Patankar, S.2026-04-22
💻 bioinformatics

Closed-Loop Multi-Objective Optimization for Receptor-Selective Cell-Penetrating Peptide Design

This paper presents a closed-loop in silico framework that integrates generative modeling, molecular simulations, and multi-objective Bayesian optimization to successfully design cell-penetrating peptides with receptor-selective binding profiles, as validated by experimental imaging showing preferential enrichment in CXCR4-positive regions over NRP1-positive regions.

Yamahata, I., Shimamura, T., Hayashi, S.2026-04-21
💻 bioinformatics

Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome associated Alzheimer disease

This study identifies epigenetically constrained basal astrocytes in the prefrontal cortex as a key vulnerability factor in Down syndrome-associated Alzheimer's disease, characterized by a loss of homeostatic functions and diminished responsiveness to stress and inflammatory signals rather than classical reactive activation.

Sun, C., Thomas, R., Stringer, C., Galani, K., Ho, L.-L., Sun, N., Renfro, A., Wright, S., Firenze, R., Tsai, L.-H., Hea (…)2026-04-21
💻 bioinformatics

3D Reconstruction of Nanoparticle Distribution in Tumor Spheroids with Volume Electron Microscopy

This paper presents a reproducible, open analytical pipeline combining a fine-tuned Cellpose-SAM model for cellular structures and an empirical Bayes approach for nanoparticles to achieve fully quantitative 3D reconstruction of nanoparticle distribution and cellular morphology within tumor spheroids using volume electron microscopy.

Bottone, D., Gerken, L. R., Habermann, S., Mateos, J. M., Lucas, M. S., Riemann, J., Fachet, M., Resch-Genger, U., Kissl (…)2026-04-21
💻 bioinformatics

Genome-wide identification and characterization of the NAC transcription factor family in Cynodon dactylon and their expression during abiotic stresses

This study presents the first comprehensive genome-wide identification and characterization of 237 NAC transcription factor genes in *Cynodon dactylon*, revealing their phylogenetic diversity, tissue-specific expression patterns, and distinct upregulation or downregulation profiles in response to drought, heat, salt, and submergence stresses, thereby establishing a foundation for breeding stress-resilient bermudagrass.

Poudel, A., Wu, Y.2026-04-20
💻 bioinformatics

Integrating targeted genome mining and structure-guided modeling reveals unexplored 7-deazapurine-containing pathways

By integrating large-scale targeted genome mining of approximately 2 million bacterial genomes with structure-guided modeling, this study uncovers over 900 uncharacterized 7-deazapurine biosynthetic gene clusters and elucidates the enzymatic mechanisms driving their structural diversification.

Cediel-Becerra, J. D. D., Chevrette, M. G., de Crecy-Lagard, V., Dias, R.2026-04-19