Conditionally Site-Independent Neural Evolution of Antibody Sequences

This paper introduces CoSiNE, a deep neural network-parameterized continuous-time Markov chain that bridges the gap between expressive deep learning and classical phylogenetic models to capture epistatic interactions in antibody evolution, thereby outperforming state-of-the-art language models in variant effect prediction and enabling efficient affinity optimization through a novel Guided Gillespie sampling scheme.

Stephen Zhewen Lu, Aakarsh Vermani, Kohei Sanno, Jiarui Lu, Frederick A Matsen, Milind Jagota, Yun S. Song2026-03-09🤖 cs.LG

Exploratory Memory-Augmented LLM Agent via Hybrid On- and Off-Policy Optimization

The paper introduces EMPO2^2, a hybrid reinforcement learning framework that integrates memory-augmented on- and off-policy optimization to overcome exploration bottlenecks in LLM agents, achieving significant performance gains on benchmark tasks and demonstrating superior adaptability to out-of-distribution scenarios without parameter updates.

Zeyuan Liu, Jeonghye Kim, Xufang Luo, Dongsheng Li, Yuqing Yang2026-03-09🤖 cs.AI

Coverage-Aware Web Crawling for Domain-Specific Supplier Discovery via a Web--Knowledge--Web Pipeline

This paper proposes a Coverage-Aware Web Crawling framework utilizing a Web--Knowledge--Web pipeline and ecological species-richness estimators to iteratively discover and map under-represented SME suppliers in specialized sectors, achieving superior precision and efficiency compared to baseline methods in the semiconductor equipment manufacturing industry.

Yijiashun Qi, Yijiazhen Qi, Tanmay Wagh2026-03-09🤖 cs.LG

Reparameterized Tensor Ring Functional Decomposition for Multi-Dimensional Data Recovery

This paper proposes a reparameterized Tensor Ring functional decomposition that leverages Implicit Neural Representations and a structured basis combination to overcome the high-frequency modeling limitations of traditional methods, achieving superior performance in multi-dimensional data recovery tasks such as image inpainting and point cloud reconstruction.

Yangyang Xu, Junbo Ke, You-Wei Wen, Chao Wang2026-03-09🤖 cs.AI

LMU-Based Sequential Learning and Posterior Ensemble Fusion for Cross-Domain Infant Cry Classification

This paper proposes a compact acoustic framework that combines multi-branch CNN feature extraction with an efficient Legendre Memory Unit (LMU) for temporal modeling and a calibrated posterior ensemble fusion strategy to achieve robust, real-time cross-domain infant cry classification despite limited annotations and strong domain shifts.

Niloofar Jazaeri, Hilmi R. Dajani, Marco Janeczek, Martin Bouchard2026-03-09🤖 cs.LG

Rigidity-Aware Geometric Pretraining for Protein Design and Conformational Ensembles

This paper introduces RigidSSL, a rigidity-aware self-supervised learning framework that pretrains on static and dynamic protein structures using a bi-directional flow matching objective to jointly optimize geometric understanding and conformational dynamics, thereby significantly improving protein designability, novelty, and the modeling of realistic conformational ensembles.

Zhanghan Ni, Yanjing Li, Zeju Qiu, Bernhard Schölkopf, Hongyu Guo, Weiyang Liu, Shengchao Liu2026-03-09🤖 cs.AI

Traversal-as-Policy: Log-Distilled Gated Behavior Trees as Externalized, Verifiable Policies for Safe, Robust, and Efficient Agents

This paper proposes "Traversal-as-Policy," a framework that distills sandboxed execution logs into verifiable Gated Behavior Trees to replace implicit LLM policies with explicit, state-conditioned macro traversals, thereby significantly improving success rates, eliminating safety violations, and reducing computational costs across diverse autonomous agent benchmarks.

Peiran Li, Jiashuo Sun, Fangzhou Lin, Shuo Xing, Tianfu Fu, Suofei Feng, Chaoqun Ni, Zhengzhong Tu2026-03-09🤖 cs.AI

Clinical-Injection Transformer with Domain-Adapted MAE for Lupus Nephritis Prognosis Prediction

This paper proposes a novel multimodal framework, the Clinical-Injection Transformer with a domain-adapted MAE, which integrates routine PAS-stained histopathology images and clinical data to achieve high-accuracy three-class prognosis prediction for pediatric lupus nephritis, addressing previous limitations in data availability and modality integration.

Yuewen Huang, Zhitao Ye, Guangnan Feng, Fudan Zheng, Xia Gao, Yutong Lu2026-03-09🤖 cs.LG

JAWS: Enhancing Long-term Rollout of Neural Operators via Spatially-Adaptive Jacobian Regularization

The paper introduces JAWS, a probabilistic regularization strategy that dynamically modulates Jacobian constraints based on local physical complexity to resolve the contraction-dissipation dilemma, thereby enabling memory-efficient, short-horizon optimization to achieve superior long-term stability and accuracy in neural operator rollouts for dynamical systems.

Fengxiang Nie, Yasuhiro Suzuki2026-03-09🤖 cs.AI

Attention Meets Reachability: Structural Equivalence and Efficiency in Grammar-Constrained LLM Decoding

This paper establishes that while language-equivalent context-free grammars yield identical token masks in grammar-constrained decoding, their structural differences significantly impact computational efficiency by introducing variable state-space blowups and ambiguity costs, leading to fundamental lower bounds on decoding work and new distortion metrics for masked sampling.

Faruk Alpay, Bilge Senturk2026-03-09🤖 cs.LG