Inferring Clinically Relevant Molecular Subtypes of Pancreatic Cancer from Routine Histopathology Using Deep Learning
The paper introduces PanSubNet, an interpretable deep learning framework that accurately predicts clinically relevant basal-like and classical molecular subtypes of pancreatic ductal adenocarcinoma directly from routine H&E-stained histology slides, offering a cost-effective and rapid alternative to traditional RNA-seq-based methods for precision oncology.
Abdul Rehman Akbar, Alejandro Levya, Ashwini Esnakula, Elshad Hasanov, Anne Noonan, Lingbin Meng, Susan Tsai, Vaibhav Sahai, Midhun Malla, Sarbajit Mukherjee, Upender Manne, Anil Parwani, Wei Chen, Ashish Manne, Muhammad Khalid Khan Niazi2026-03-12⚡ eess