An Interpretable AI Framework for Multiclass Classification of Thalassemia Using Combined CBC and HPLC Biomarkers
This paper presents an interpretable multimodal machine learning framework that combines CBC and HPLC biomarkers to achieve highly accurate (99.89%) and clinically consistent multiclass classification of thalassemia using a stacking ensemble model, with SHAP analysis confirming the top predictive features align with standard diagnostic criteria.