Extracting and analyzing 3D histomorphometric features related to perineural and lymphovascular invasion in prostate cancer
This study presents a 3D histomorphometric analysis pipeline using nnU-Net segmentation on optically cleared prostatectomy specimens to extract features related to perineural and lymphovascular invasion, demonstrating that 3D perineural invasion features significantly outperform their 2D counterparts in predicting 5-year biochemical recurrence in prostate cancer.