Targeting Bothrops asper Venom Enzymes: Steroidal Derivatives as potential Inhibitors of Phospholipase A2, Serine proteinases, and metalloproteinases.
This study demonstrates that semi-synthetic ergosterol-derived compounds, particularly compound 4 for serine proteinases and compounds 2 and 3 for phospholipase A2, effectively inhibit key *Bothrops asper* venom enzymes through hydrophobic and electrostatic interactions, suggesting their potential as adjuvants for treating snakebite-induced local damage.