193 papers
Genetics is the fascinating study of how traits are passed down and how our DNA shapes everything from eye color to disease risk. At Gist.Science, we bring you the very latest discoveries in this dynamic field directly from bioRxiv, the leading preprint server for biology. Because these findings appear months before formal publication, staying updated requires sifting through complex data that often feels inaccessible to non-specialists.
To bridge that gap, our team processes every new genetics preprint uploaded to bioRxiv, transforming dense scientific reports into clear, plain-language explanations alongside detailed technical summaries. This dual approach ensures that whether you are a seasoned researcher or simply curious about how genes work, you can grasp the core insights without getting lost in jargon. Below are the latest papers in genetics, curated and simplified for your reading.
This pilot longitudinal study demonstrates that initiating elexacaftor/tezacaftor/ivacaftor (ETI) treatment in cystic fibrosis patients significantly decelerates epigenetic aging, an effect that correlates with reduced inflammatory biomarkers and improved clinical disease markers.
The GeneSIS framework enhances the transferability of polygenic scores across diverse genetic ancestry groups by integrating variant-level gene-by-sex interaction effects, resulting in significantly improved disease prediction accuracy for non-European populations.
This study reveals that the human-specific expansion and remodeling of the K111 endogenous retrovirus drive complex, generation-spanning structural diversity and sequence exchange within the nucleolar organizer regions of all five acrocentric chromosomes, establishing it as a dynamic molecular record of human genome evolution.
This study identifies *rfk-2* as a specific gene within the *Neurospora* Sk-3 selfish element that is essential but insufficient for spore killing, revealing that the element relies on multiple genes rather than a single killer gene to subvert Mendelian inheritance.
This study demonstrates a rapid breeding strategy that combines a large-scale recombinant population with interpretable genomic prediction models to efficiently construct rice cultivars with optimal multi-trait genotypes, successfully validating the approach through the development of lines with targeted yield-related traits.
This study utilized microsatellite markers and a multicategory model to demonstrate that while 12 polyploid sugarcane families exhibit high inter-family similarity, the majority of genetic diversity (72%) resides within families, highlighting significant potential for breeding selection and the necessity of using appropriate distance metrics for polyploid analysis.
This study reveals that echinocandin resistance in the globally emerging fungal pathogen *Candida auris* arises through parallel evolution driven by strong genetic constraints, where adaptive mutations are restricted to specific hotspots within the *FKS1* gene rather than its paralog *FKS2*.
This study demonstrates that cohesin maintains genomic stability by confining DNA repair to local sequences through high-density arm cohesion, thereby suppressing unequal sister chromatid exchange between distal repetitive regions, a protective mechanism that fails when cohesin loading or arm cohesion is compromised.
This paper develops a diploid stochastic model demonstrating that overdispersion in active transposable element copy numbers naturally arises from transposition-induced positive linkage disequilibrium, a mechanism that aligns with empirical data from *Drosophila melanogaster* and challenges classical Poisson-based predictions.
This study demonstrates that ectopic gene conversion, driven by genome architecture rather than population history, recurrently reintroduces specific nucleotide changes, thereby shaping a significant fraction of human allele frequencies and challenging the traditional single-origin assumption in population genetics.