210 papers
This study demonstrates that the meiotic recombination rate in *Saccharomyces cerevisiae* is highly evolvable under divergent selection, achieving significant local changes within ten generations through the selection of specific haplotypes and the reduction of heterozygosity, though genome-wide effects varied across independent lineages.
Heterologous expression of the human cohesin complex in *Saccharomyces cerevisiae* fails to rescue yeast cohesin mutants and instead induces a dominant-negative phenotype by forming dysfunctional hybrid complexes with endogenous yeast cohesin rings, leading to cohesion dysregulation and DNA damage sensitivity.
This study demonstrates that somatic DNA methylation heterogeneity within *Arabidopsis* leaves serves as a predictor for extreme transgenerational epimutation hotspots, providing evidence that spontaneous epimutations originate during meristematic growth and propagate clonally through developmental lineages.
The paper introduces ARGMix, a graph transformer that leverages ancient DNA within an ancestral recombination graph framework to significantly improve the accuracy and robustness of local ancestry inference, particularly for older admixture events where traditional segment-based methods struggle.
This study proposes reclassifying glycopeptide antibiotics into the broader class of xyclopeptides, subdivided into dalabactins (classical types I–IV) and murobactins (type V), based on structural and evolutionary analyses that reveal a fundamental divergence between these two groups.
This paper introduces and validates a novel statistical model using the expectation-maximization algorithm to accurately estimate population-level frequencies of *Plasmodium falciparum* haplotypes with *Pfhrp2/3* deletions, overcoming the limitations of standard molecular assays in detecting these deletions within mixed-clone infections.
This study demonstrates that adult-derived polygenic g scores effectively chart the cognitive development of children, showing minimal predictive power in toddlerhood that increases substantially to explain 12% of variance in early adulthood while also correlating with educational achievement and faster cognitive growth.
This study demonstrates that combining high-throughput multi-spectral field imaging with controlled-environment assays effectively overcomes spatial variability to detect genetic variation for iron deficiency chlorosis tolerance in sorghum, thereby enabling the development of crops resilient to alkaline soils.
This study presents a preliminary 16S rRNA metagenomic analysis of six soil samples from North-Central Argentine agroecosystems, revealing a dominance of copiotrophic bacteria alongside specific oligotrophic taxa and characterizing the abundance of agronomically relevant genera to expand understanding of microbial diversity beyond the Pampas region.
This study reveals that maize K180 constitutive heterochromatin exhibits unique, tissue-specific chromatin accessibility dynamics during development, contrasting with the consistently closed states of TR-1 knobs and centromeres.
This study reveals that cis-regulatory nucleotide changes located between conserved transcription factor binding sites drove increased TDH3 promoter activity in *S. cerevisiae* by modulating the collective assembly of regulators, including TYE7p, thereby allowing expression levels to evolve independently of expression dynamics.
This study utilizes advanced forensic genetic analysis of skeletal remains from Columbus's descendants interred in Gelves, Spain, to reconstruct kinship networks that provide indirect but consistent evidence supporting a specific hypothesis regarding the discoverer's debated geographical and familial origins.
This study identifies the stable *Ma1* gene and associated QTLs as key drivers of photoperiodic flowering plasticity in sorghum, which effectively delays maturity to escape grain mold and stabilize yields across diverse subhumid environments, providing a foundation for molecular breeding of climate-resilient varieties.
This study reveals that the plant-specific ULTRAPETALA1 (ULT1) protein acts as a dual trxG/PcG factor that physically interacts with and enhances the enzymatic activity of PRC2 complexes containing the SWINGER subunit to increase H3K27me3 levels, thereby providing a novel mechanism for fine-tuning reproductive transitions through a chromatin state switch.
This study reveals that tissue-specific isoform regulation drives the divergent genetic architecture of epilepsy and SUDEP, demonstrating how shared genetic risk loci are differentially deployed as heart-restricted or brain-restricted transcripts to cause cardiac vulnerability and neuronal dysfunction, respectively.
This study presents a unified multi-kernel mixed model that integrates oligogenic and polygenic indirect genetic effects to effectively dissect the genetic architecture of group performance, revealing evidence of intergenotypic competition in woody plants and identifying specific competitive variants in apple trees.
By establishing a genetically tractable model of *Galaxea fascicularis* through lab-induced spawning and utilizing CRISPR/Cas9 mutagenesis, researchers demonstrated that heat-tolerant corals rely less on the Heat Shock Transcription Factor 1 (HSF1) pathway for survival during acute heat stress compared to heat-sensitive species, identifying HSF1 dependence as a key determinant of coral heat tolerance.
This study demonstrates that the functional partitioning of SNP heritability systematically varies with polygenicity across complex human traits, revealing a shift from gene-proximal regulatory architectures in less polygenic traits to architectures dominated by dispersed intergenic regulatory effects in highly polygenic ones.
This paper introduces a Bayesian Varying Coefficient Model (BVCM) that successfully deciphers the genetic architecture of time-dependent phenotypic plasticity across diverse species by integrating temporal and genetic multivariate structures, thereby detecting dynamic QTLs and reducing missing heritability compared to traditional time-by-time association methods.
This paper reports the development and testing of a confined Toxin-Antidote Recessive Embryo (TARE) gene drive in the malaria vector *Anopheles stephensi*, which successfully demonstrated the ability to spread in cage trials despite challenges from fitness costs and resistance alleles, suggesting that further optimization could enable effective and contained population modification.