193 papers
Genetics is the fascinating study of how traits are passed down and how our DNA shapes everything from eye color to disease risk. At Gist.Science, we bring you the very latest discoveries in this dynamic field directly from bioRxiv, the leading preprint server for biology. Because these findings appear months before formal publication, staying updated requires sifting through complex data that often feels inaccessible to non-specialists.
To bridge that gap, our team processes every new genetics preprint uploaded to bioRxiv, transforming dense scientific reports into clear, plain-language explanations alongside detailed technical summaries. This dual approach ensures that whether you are a seasoned researcher or simply curious about how genes work, you can grasp the core insights without getting lost in jargon. Below are the latest papers in genetics, curated and simplified for your reading.
This study demonstrates that copper resistance in *Drosophila melanogaster* is genetically modular, comprising heritable but architecturally distinct components of feeding avoidance, oviposition avoidance, and physiological tolerance that can evolve independently.
This study demonstrates that by optimizing irradiation parameters and performing rapid synchrotron X-ray microtomography prior to DNA extraction, researchers can successfully obtain both high-resolution 3D morphological data and high-quality genomic sequences from the same insect specimens, thereby enabling comprehensive integrative digitization of biodiversity.
This study develops the first Cytochrome Oxidase I (COI) DNA barcode for the invasive mealybug *Heliococcus summervillei*, revealing a distinct mitochondrial split between Type A and B variants and demonstrating that recent invasions across the United States, Australia, Pakistan, and the Caribbean share a single haplotype, thereby providing a critical molecular tool for rapid identification and management of this pest.
This study utilized a large panel of *Drosophila melanogaster* lines to identify significant genetic variation and specific polymorphisms in genes with human orthologs that influence cocaine consumption and preference, thereby providing insights into the genetic and neural mechanisms underlying Cocaine Use Disorder.
This paper evaluates various imputation methods for filling gaps in multiplexed assays of variant effects (MAVEs) across different genetic and environmental contexts, finding that while flexible models excel with dense data, simple regression models are more reliable for sparse data but cannot predict effects for unmeasured variants in both contexts.
A cross-sectional study of asymptomatic malaria infections in Cameroon reveals that while sickle cell trait (HbS) does not alter infection rates, it selectively enriches for specific parasite alleles (Pfsa+) that may help the parasite overcome host defenses, highlighting a complex co-evolutionary dynamic involving both resistance and tolerance.
This study established an optimized SNP-PCR system to analyze the genetic diversity and 1-DNJ phenotypic variation in 51 mulberry germplasms, identifying significant genetic differentiation and six SNP sites weakly correlated with 1-DNJ content to support future molecular-assisted breeding efforts.
This paper presents a comprehensive characterization and public release of diverse human cell lines engineered with various NF1 gene variants, providing essential resources for researchers to study neurofibromin function, phenotypes, and develop targeted therapeutics for Neurofibromatosis type 1.
This study demonstrates that individuals homozygous for either rare or common hypomorphic IL23R variants exhibit impaired IL-23 signaling and IFN-gamma production in innate immune cells, conferring a specific genetic predisposition to tuberculosis while maintaining immunity against less virulent mycobacteria.
This study characterizes the moderate genetic diversity and distinct population structure of 250 maize doubled haploid lines derived from drought and low nitrogen-tolerant populations, confirming their value as a robust genetic resource for developing stress-resilient tropical maize cultivars.