🧬 Category

genetics

194 papers

Genetics is the fascinating study of how traits are passed down and how our DNA shapes everything from eye color to disease risk. At Gist.Science, we bring you the very latest discoveries in this dynamic field directly from bioRxiv, the leading preprint server for biology. Because these findings appear months before formal publication, staying updated requires sifting through complex data that often feels inaccessible to non-specialists.

To bridge that gap, our team processes every new genetics preprint uploaded to bioRxiv, transforming dense scientific reports into clear, plain-language explanations alongside detailed technical summaries. This dual approach ensures that whether you are a seasoned researcher or simply curious about how genes work, you can grasp the core insights without getting lost in jargon. Below are the latest papers in genetics, curated and simplified for your reading.

🧬 genetics

Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging

This study demonstrates that while strong inhibition of insulin/IGF-1 signaling during early-to-mid adulthood compresses morbidity and extends lifespan, the optimal strategy for maximizing both healthspan and longevity involves temporally modulating this pathway, as its reduction in later life can paradoxically accelerate aging while its cessation in the elderly can rejuvenate function.

Zhang, B., Hsiung, K. C., Biju, R., Cameron-Pack, M., Wei, X., Chapman, H., Kelaj, M., Zhang, A., Nguyen Hong, C., Ewald (…)2026-04-16
🧬 genetics

Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brain

This study demonstrates that humanized Klotho haplotypes (FC and VS) induce widespread, age-dependent transcriptomic changes in the mouse brain—particularly affecting mitochondrial, ribosomal, and synaptic functions, including glutamate receptors and amyloid precursor processing—thereby supporting the hypothesis that these genetic variants influence Alzheimer's disease risk and pathogenesis.

Tyler, A. L., Garceau, D., Kotredes, K. P., Haber, A., Spruce, C., Pandey, R. S., Preuss, C., Sasner, M. J., Carter, G. (…)2026-04-16
🧬 genetics

Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation

This study demonstrates that Propionyl-CoA Carboxylase deficiency in hepatocytes reprograms hepatic metabolism by suppressing mitochondrial pyruvate carboxylation and fatty acid oxidation while increasing glucose oxidation, thereby impairing gluconeogenesis and lipid synthesis and highlighting the metabolic risks of prolonged fasting in Propionic Acidemia patients.

Lu, F., Paiboonrungruang, C., He, W., Xiong, Z., Tang, P., Kasumov, T., Chen, X., Zhang, G.2026-04-15
🧬 genetics

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

This study demonstrates that environmentally relevant concentrations of Bisphenol A induce DNA damage and R-loop accumulation, identifying DNA repair mechanisms and the RNA helicase DDX21 as critical regulators of cellular resistance to this chemical.

Hale, A., Nusawardhana, A., Straka, J., Nicolae, C. M., Moldovan, G.-L.2026-04-15
🧬 genetics

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

This study demonstrates that the impact of knocking down autophagy genes on *C. elegans* longevity is highly dependent on specific experimental conditions, including temperature, genetic background, and chemical treatments, thereby challenging the universal necessity of autophagy for lifespan extension and highlighting the risk of selection bias in such research.

Hsiung, K. C., Chapman, H., Wei, X., Sun, X., Rawlinson, I., Gems, D.2026-04-14
🧬 genetics

Genetic analysis of bone morphometry and ivory vertebrae in threespine stickleback

This study utilizes quantitative trait locus mapping in threespine stickleback to identify specific genetic loci, including the Eda region and a Tnfrsf1b-associated locus on chromosome 17, that govern natural variation in bone microstructure and a disease-like "ivory vertebrae" phenotype, thereby establishing the species as a valuable model for both evolutionary and pathological bone research.

Behrens, V. C., Lee, D., Wucherpfennig, J. I., Kingsley, D. M.2026-04-14