🧬 Category

genetics

121 papers

Genetics is the fascinating study of how traits are passed down and how our DNA shapes everything from eye color to disease risk. At Gist.Science, we bring you the very latest discoveries in this dynamic field directly from bioRxiv, the leading preprint server for biology. Because these findings appear months before formal publication, staying updated requires sifting through complex data that often feels inaccessible to non-specialists.

To bridge that gap, our team processes every new genetics preprint uploaded to bioRxiv, transforming dense scientific reports into clear, plain-language explanations alongside detailed technical summaries. This dual approach ensures that whether you are a seasoned researcher or simply curious about how genes work, you can grasp the core insights without getting lost in jargon. Below are the latest papers in genetics, curated and simplified for your reading.

Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation

This study demonstrates that Propionyl-CoA Carboxylase deficiency in hepatocytes reprograms hepatic metabolism by suppressing mitochondrial pyruvate carboxylation and fatty acid oxidation while increasing glucose oxidation, thereby impairing gluconeogenesis and lipid synthesis and highlighting the metabolic risks of prolonged fasting in Propionic Acidemia patients.

Lu, F., Paiboonrungruang, C., He, W., Xiong, Z., Tang, P., Kasumov, T., Chen, X., Zhang, G.2026-04-15🧬 genetics

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

This study demonstrates that environmentally relevant concentrations of Bisphenol A induce DNA damage and R-loop accumulation, identifying DNA repair mechanisms and the RNA helicase DDX21 as critical regulators of cellular resistance to this chemical.

Hale, A., Nusawardhana, A., Straka, J., Nicolae, C. M., Moldovan, G.-L.2026-04-15🧬 genetics

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

This study demonstrates that the impact of knocking down autophagy genes on *C. elegans* longevity is highly dependent on specific experimental conditions, including temperature, genetic background, and chemical treatments, thereby challenging the universal necessity of autophagy for lifespan extension and highlighting the risk of selection bias in such research.

Hsiung, K. C., Chapman, H., Wei, X., Sun, X., Rawlinson, I., Gems, D.2026-04-14🧬 genetics

Genetic analysis of bone morphometry and ivory vertebrae in threespine stickleback

This study utilizes quantitative trait locus mapping in threespine stickleback to identify specific genetic loci, including the Eda region and a Tnfrsf1b-associated locus on chromosome 17, that govern natural variation in bone microstructure and a disease-like "ivory vertebrae" phenotype, thereby establishing the species as a valuable model for both evolutionary and pathological bone research.

Behrens, V. C., Lee, D., Wucherpfennig, J. I., Kingsley, D. M.2026-04-14🧬 genetics

Temporal dynamics and acquisition of Shiga toxin subtype stx2a within Shiga toxin-producing Escherichia coli in England, 2016 to 2024

An analysis of 12,888 STEC genomes in England from 2016 to 2024 reveals a significant temporal shift toward non-O157 serogroups, particularly O26:H11 and O145:H28, driven by the widespread and increasing prevalence of the high-risk stx2a toxin subtype, underscoring the critical value of genomic surveillance for monitoring emerging public health threats.

Hayles, E. H., Rodwell, E. V., Greig, D. R., Jenkins, C., Langridge, G. C.2026-04-12🧬 genetics

A genome-wide in vivo screen reveals fitness pathways required for streptococcal infective endocarditis

This study presents the first genome-wide in vivo screen identifying 146 conserved *Streptococcus* genes and pathways essential for infective endocarditis fitness, revealing broad evolutionary conservation and novel targets for multi-target antimicrobial strategies.

Bao, L., Bradley, J., Anandan, V., Tyc, K., Zhu, Z., Vossen, J. A., Assi, V. F., Benbei, J., Zollar, N., Kitten, T., Xu, P.2026-04-10🧬 genetics

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells

This study identifies a genetic variant (rs17437411) that disrupts a newly characterized homeotic long noncoding RNA called HOTSCRAMBL, which is essential for regulating HOXA gene expression, maintaining hematopoietic stem cell self-renewal, and supporting the development of HOXA-dependent acute myeloid leukemias.

Lyu, P., Agarwal, G., Guo, C.-J., Sychla, A., Bourgeois, W., Ye, T., Weng, C., Antoszewski, M., Joubran, S., Caulier, A., Poeschla, M., Armstrong, S. A., Rouskin, S., Sankaran, V. G.2026-04-09🧬 genetics