genomics papers | Gist.Science

Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland

This paper introduces OneCell CUT&Tag, a user-friendly single-cell multi-omics method capable of profiling chromatin, transcriptomes, and surface markers from individual cells, which was used to reveal continuous epigenomic priming and a binary transcriptomic switch during basal-to-luminal transdifferentiation in the mammary gland.

Schwager, A., Moutaux, E., Durand, A. + 23 more2026-02-17🧬 genomics

RNA-binding proteins and regulatory networks involved in life-stage, stress temperature, and drug resistance in Leishmania parasites

This study establishes a comprehensive comparative atlas of RNA-binding proteins across 19 Leishmania species, revealing a conserved regulatory core, lineage-specific adaptations, and distinct RNA modification machinery, while specifically linking these proteins to life-stage transitions, stress responses, and antimony drug resistance mechanisms in L. braziliensis.

Martinez-Hernandez, J. E., Aliaga Tobar, V., Hidalgo-Cabrera, A. + 4 more2026-02-17🧬 genomics

commonPeak: Equivalence testing to identify common ChIP-seq peaks across conditions and protocols

The paper introduces commonPeak, a statistical framework that identifies shared ChIP-seq peaks and tests for equivalent enrichment across conditions and protocols, thereby enabling the benchmarking of workflows and the distinction between conserved and condition-specific regulatory programs.

Swillus, A. H., Tiso, F., Annaldasula, S. + 4 more2026-02-17🧬 genomics

The genome sequence of Pavonine herpesvirus 1, a novel Mardivirus infecting peafowl

This study presents the genome sequence of Pavonine herpesvirus 1 (PaHv1), a novel, likely non-oncogenic Mardivirus infecting peafowl that lacks key oncogenic genes found in Marek's disease virus, thereby expanding the understanding of herpesvirus diversity and evolution in galliform birds.

Fiddaman, S. R., Barbosa, S., Carneiro, M. + 2 more2026-02-17🧬 genomics

Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation

This study presents a high-quality long-read genome sequence of *Digitalis purpurea* that elucidates the molecular mechanisms underlying its flower color variation, caused by a disruptive insertion in the anthocyanidin synthase gene, and its terminal flower morphology, driven by a large insertion in the *DpTFL1/CEN* gene.

Horz, J. M., Wolff, K., Friedhoff, R. + 1 more2026-02-16🧬 genomics

How Ant Genomes Repeatedly Reinvent Venom

Through synteny-aware comparative genomics of 25 ant species, this study reveals that ant venom evolution is driven by the recurrent recruitment of diverse toxin clades to three conserved genomic hotspots, demonstrating how stable genomic scaffolds facilitate complex adaptive traits through a combination of single-copy conservation, massive gene duplication, and lineage-specific expansion.

Weitz, F. A., Hita Garcia, F., von Reumont, B. M. + 2 more2026-02-16🧬 genomics

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