13909 papers
This study demonstrates that optimized real-time quaking-induced conversion assays can successfully detect pathological α-synuclein seeding activity in paraformaldehyde-fixed antemortem skin biopsies from patients with synucleinopathies, offering a viable method to complement morphological assessments of peripheral pathology.
This real-world cohort study of 4,165 breast cancer patients reveals that targeted therapies, particularly CDK4/6 inhibitors and everolimus, are significantly associated with increased risks of arterial and venous thrombosis, with nicotine dependence, brain metastases, and higher BMI identified as key independent patient-level risk factors.
This cross-sectional study of 468 Indian medical students reveals that while overall perceptions of Competency-Based Medical Education remain consistent across academic phases, significant variations exist in specific domains like Early Clinical Exposure and attitudes toward challenges, highlighting the need for phase-sensitive implementation strategies.
This case report demonstrates that combining subglandular breast implants with intraoperative contour-guided autologous fat grafting effectively addresses soft-tissue deficiencies and refines breast contours in slender patients, resulting in satisfactory aesthetic outcomes without significant complications.
This study demonstrates that in Japan, switching trastuzumab plus pertuzumab from intravenous to subcutaneous administration improves hospital financial outcomes by significantly reducing material and labor costs, which outweighs the lower outpatient management fee revenue.
This paper proposes the Hepatic Insulin Resistance Syndrome (HIRS) framework as a biologically coherent, insulin resistance-based alternative to the current MASLD classification for diagnosing and staging steatotic liver disease, pending future empirical validation.
This study utilizes unsupervised cluster analysis on 64 confirmed scrub typhus cases to identify two distinct clinical phenotypes—a typical polysymptomatic group and an atypical severe-prone group characterized by the absence of classic local signs but higher rates of respiratory/neurological complications and treatment failure—thereby highlighting the need for early risk stratification beyond traditional diagnostic markers.
This retrospective cross-sectional study of 360 patients at a referral hospital in Addis Ababa reveals a rising burden of louse-borne relapsing fever with a 6.1% mortality rate, identifying central nervous system symptoms, chest crepitations, septic shock, and abdominal pain as key independent predictors of death to guide triage and public health interventions.
This prospective study demonstrates that a logistic regression-based nomogram integrating clinical data with CT-derived muscle-fat parameters effectively predicts geriatric hip fracture risk, offering a simple and interpretable tool that performs comparably to or better than complex machine learning algorithms.
The study demonstrates that the harmine derivative ACB1801 sensitizes microsatellite-stable colorectal cancer to anti-PD-1 immunotherapy by reprogramming the tumor microenvironment through STAT1-mediated CXCL10 secretion, enhanced MHC class I antigen presentation, and ferroptosis vulnerability, thereby converting immunologically "cold" tumors into an immune-responsive state.