14263 papers
This multicenter Asian registry study found that preoperative chemoradiotherapy did not significantly improve disease-free or overall survival compared to upfront surgery in patients with early-onset clinical stage II–III rectal cancer who underwent surgical resection.
This study demonstrates that conversion total hip arthroplasty using a cementless monoblock tapered fluted revision stem provides reliable femoral fixation and acceptable functional outcomes for patients with failed proximal femur fracture fixation due to broken cephalomedullary nails, although postoperative functional results are significantly influenced by preoperative ASA grade.
This cross-sectional study of 1,007 Chinese pregnant women found that higher dietary intakes of spermidine and putrescine, but not spermine, were significantly associated with an increased prevalence of gestational diabetes mellitus.
This study demonstrates that in critically ill patients, the spatial QRS-T angle derived from the first ECG is the strongest predictor of 28-day mortality, while new-onset repolarization abnormalities serve as early warning signals for arrhythmias and myocardial injury, establishing whole-cycle ECG dynamics as a comprehensive, actionable monitoring tool for prognosis and pharmacodynamic assessment in the ICU.
A study of 30 parents found that a majority would accept participating in a first-in-human trial of artificial womb technology for 23-week gestational infants, driven by hope for better outcomes, though their willingness depends on transparent communication regarding risks and trial safeguards.
This study reveals that while baseline host inflammatory fitness predicts early treatment success in relapsed/refractory large B-cell lymphoma, the distinct long-term efficacy of axi-cel versus tisa-cel is driven by qualitative immune remodeling, where axi-cel's unique ability to induce balanced CAR-T expansion and bystander activation yields more durable responses despite lower peripheral cell counts.
This prospective cohort study of Swedish twins reveals that an ischemic heart disease diagnosis is associated with a reduced probability of sustainable working life, a relationship partially explained by shared genetic and early-life environmental factors rather than sex or common mental disorders.
This retrospective study demonstrates that gonadotropin-releasing hormone agonist treatment effectively suppresses puberty and attenuates skeletal maturation in children with Lennox–Gastaut syndrome and central precocious puberty, while also suggesting that underlying neurological etiologies, such as hypoxic–ischemic encephalopathy, may influence the severity of bone age advancement and treatment response.
This retrospective qualitative study in eastern Uganda identifies that adverse pregnancy outcomes stem from fragmented care pathways, systemic health system weaknesses (including inadequate staffing, supplies, and referrals), and socio-cultural barriers, underscoring the urgent need for integrated interventions that strengthen clinical practices, referral systems, and community health literacy.
This retrospective study of Finnish medico-legal deaths from 2016 to 2024 reveals that while detections of ADHD medications in post-mortem cases have risen in parallel with prescription rates, fatalities directly attributed to these drugs remain rare, with the deceased predominantly representing a high-risk subgroup characterized by significant substance-use comorbidity and unnatural causes of death.