14263 papers
This study demonstrates that in Japan, switching trastuzumab plus pertuzumab from intravenous to subcutaneous administration improves hospital financial outcomes by significantly reducing material and labor costs, which outweighs the lower outpatient management fee revenue.
This paper proposes the Hepatic Insulin Resistance Syndrome (HIRS) framework as a biologically coherent, insulin resistance-based alternative to the current MASLD classification for diagnosing and staging steatotic liver disease, pending future empirical validation.
This study utilizes unsupervised cluster analysis on 64 confirmed scrub typhus cases to identify two distinct clinical phenotypes—a typical polysymptomatic group and an atypical severe-prone group characterized by the absence of classic local signs but higher rates of respiratory/neurological complications and treatment failure—thereby highlighting the need for early risk stratification beyond traditional diagnostic markers.
This retrospective cross-sectional study of 360 patients at a referral hospital in Addis Ababa reveals a rising burden of louse-borne relapsing fever with a 6.1% mortality rate, identifying central nervous system symptoms, chest crepitations, septic shock, and abdominal pain as key independent predictors of death to guide triage and public health interventions.
This prospective study demonstrates that a logistic regression-based nomogram integrating clinical data with CT-derived muscle-fat parameters effectively predicts geriatric hip fracture risk, offering a simple and interpretable tool that performs comparably to or better than complex machine learning algorithms.
The study demonstrates that the harmine derivative ACB1801 sensitizes microsatellite-stable colorectal cancer to anti-PD-1 immunotherapy by reprogramming the tumor microenvironment through STAT1-mediated CXCL10 secretion, enhanced MHC class I antigen presentation, and ferroptosis vulnerability, thereby converting immunologically "cold" tumors into an immune-responsive state.
This study evaluates the quality of patient education on robot-assisted radical prostatectomy generated by ChatGPT, DeepSeek, and Doubao, finding that while all models provide factually accurate information suitable for clinician review, ChatGPT offers superior actionability and completeness, though none fully replace the need for individualized urologist counseling.
This study demonstrates that patients with vasovagal syncope exhibit a significant increase in prolactin levels during head-up tilt testing, which correlates with hemodynamic changes and suggests a potential role for the central serotonergic system in the condition's pathophysiology, while growth hormone levels remain unchanged.
This case report describes a rare instance of indolent postoperative endophthalmitis caused by multidrug-resistant *Enterobacter hormaechei* in a patient with central retinal vein occlusion, highlighting the diagnostic utility of metagenomic next-generation sequencing for identifying low-abundance pathogens and the necessity of pars plana vitrectomy when intravitreal antibiotics fail to resolve persistent vitreous opacity.
This CHARLS cohort study of 11,050 middle-aged and older Chinese adults reveals that persistent short sleep, rather than variable short sleep, is independently associated with an increased risk of incident cardiovascular events, with the highest risk observed in individuals exhibiting both persistent short sleep and high metabolic risk scores, particularly among women.